EDMS Published theses

2024

Understanding hormone signaling and its risk on estrogen receptor-positive breast cancer

C. H. Venturi Ronchi / C. Brisken (Dir.)  

Lausanne, EPFL, 2024. 

Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae’s environmental lifestyle

S. B. Otto / M. Blokesch (Dir.)  

Lausanne, EPFL, 2024. 

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

A. Agnoletto / C. Brisken (Dir.)  

Lausanne, EPFL, 2024. 

Engineering a synthetic signaling network in dendritic cells to improve anti-tumoral immunity

Y. Mohammadzadeh / M. De Palma (Dir.)  

Lausanne, EPFL, 2024. 

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

A. Ghasemi / M. De Palma (Dir.)  

Lausanne, EPFL, 2024. 

Targeting the aging of tumor-associated neutrophils in lung cancer

A. Bodac / F. Radtke; E. Meylan (Dir.)  

Lausanne, EPFL, 2024. 

Identifying resistance mechanisms and combination therapies in Notch-driven triple negative breast cancer

M. Fournier / F. Radtke (Dir.)  

Lausanne, EPFL, 2024. 

The role of LRRK2 in lung adenocarcinoma

A. Gkasti / D. Constam; E. Meylan (Dir.)  

Lausanne, EPFL, 2024. 

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

M. U. Anwar / F. G. van der Goot Grunberg; G. D’Angelo (Dir.)  

Lausanne, EPFL, 2024. 

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

N. E. Samson / A. Ablasser (Dir.)  

Lausanne, EPFL, 2024. 

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

A. S. Petruzzella / E. Oricchio (Dir.)  

Lausanne, EPFL, 2024. 

Boosting CAR T-cell therapy through G-protein signal rewiring

L. Y. Smeding / P. Barth (Dir.)  

Lausanne, EPFL, 2024. 

Deciphering the role of signalling centers in limb development and regeneration

J. Zhong / E. Oricchio; C. Aztekin (Dir.)  

Lausanne, EPFL, 2024. 

2023

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

A. D. Bowler / F. Radtke (Dir.)  

Lausanne, EPFL, 2023. 

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

L. Cao / F. Radtke (Dir.)  

Lausanne, EPFL, 2023. 

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

R-A. Lambuta / E. Oricchio (Dir.)  

Lausanne, EPFL, 2023. 

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

M. Bulliard / D. Constam (Dir.)  

Lausanne, EPFL, 2023. 

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys

C. Gagnieux / D. Constam (Dir.)  

Lausanne, EPFL, 2023. 

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

A. Madurga Alonso / J. Hülsken (Dir.)  

Lausanne, EPFL, 2023. 

Metabolic dependencies of metastasis-initiating cells in breast cancer

C. M. T. Young / J. Hülsken (Dir.)  

Lausanne, EPFL, 2023. 

Functional characterization of Drosophila melanogaster immune effectors

A. L. Carboni / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2023. 

Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4

M. G. Vindfeldt / V. Simanis (Dir.)  

Lausanne, EPFL, 2023. 

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

A. A. Chryplewicz / M. De Palma; D. Hanahan (Dir.)  

Lausanne, EPFL, 2023. 

Telomere protection against oxidative stress

T. T. Nguyen / J. Lingner (Dir.)  

Lausanne, EPFL, 2023. 

Regulation and impact of TERRA R-loops at human telomeres

R. Valador Fernandes / J. Lingner (Dir.)  

Lausanne, EPFL, 2023. 

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

S. M. Placzek / D. M. Suter (Dir.)  

Lausanne, EPFL, 2023. 

Coordination of protein synthesis and degradation in mammalian cells

S. Sun / D. M. Suter (Dir.)  

Lausanne, EPFL, 2023. 

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

I. Sinenko / P. J. Dyson; F. L. P. Munier (Dir.)  

Lausanne, EPFL, 2023. 

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

M. Girardin / J. Hülsken; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2023. 

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

F. A. Brandão Sanches Vong Martins / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2023. 

2022

How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior

L. F. Lemos Rocha / M. Blokesch (Dir.)  

Lausanne, EPFL, 2022. 

Role of the androgen receptor in the human breast epithelium

F. De Martino / C. Brisken (Dir.)  

Lausanne, EPFL, 2022. 

Estrogen receptor signaling in the human breast epithelium

C. B. Constantin / C. Brisken (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting centriole fate in C. elegans development

N. Kalbfuss / P. Gönczy (Dir.)  

Lausanne, EPFL, 2022. 

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

J. C. De Tribolet-Hardy / D. Trono (Dir.)  

Lausanne, EPFL, 2022. 

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

K. Pinjusic / D. Constam (Dir.)  

Lausanne, EPFL, 2022. 

The role of the Nimrod proteins in the Drosophila immune system

B. M. Petrignani / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2022. 

The role of eosinophils in breast cancer

L. Spisak / J. Hülsken (Dir.)  

Lausanne, EPFL, 2022. 

A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo

M. A. Hanson / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2022. 

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

K. Neopane / P. Descombes; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction

F. Schyrr / E. Oricchio; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2022. 

Exploring the mechanisms governing nuclear cGAS localization and activity

M. Wischnewski / A. Ablasser (Dir.)  

Lausanne, EPFL, 2022. 

Identification and characterization of proteins that protect human telomeres from fragility

A. C. Näger / J. Lingner (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of the mitochondrial carrier SLC25A47

N. Bresciani / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

The role of nicotinamide riboside metabolism in pancreatic beta cells

A. S. Cercillieux / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2022. 

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

N. Vesel / M. Blokesch (Dir.)  

Lausanne, EPFL, 2022. 

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

C. T. J. Wall / A. Wiederkehr; D. M. Suter (Dir.)  

Lausanne, EPFL, 2022. 

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Ö. Uysal Özdemir / V. Simanis (Dir.)  

Lausanne, EPFL, 2022. 

2021

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

P. Aouad / C. Brisken (Dir.)  

Lausanne, EPFL, 2021. 

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

M. W. Antoszewski / F. Radtke; U. Koch (Dir.)  

Lausanne, EPFL, 2021. 

The role and transcriptional regulation of FAM46A in adipocyte differentiation

A-K. Hov / B. Deplancke; N. Gheldof (Dir.)  

Lausanne, EPFL, 2021. 

Intestinal stem cells differentiation and its application in cancer therapy

M. Norkin / J. Hülsken (Dir.)  

Lausanne, EPFL, 2021. 

The role of immune effectors in controlling Drosophila-microbes interactions

A. Marra / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2021. 

Investigation of physiological roles of AMPK-activated protein kinase y3

P. J. Rhein / P. Descombes; E. Meylan (Dir.)  

Lausanne, EPFL, 2021. 

The molecular treasure box of environmental Vibrio cholerae strains

N. C. Drebes Dörr / M. Blokesch (Dir.)  

Lausanne, EPFL, 2021. 

2020

Molecular profiling and functional analysis of macrophage-derived tumour extracellular vesicles

T. Beltraminelli / M. De Palma (Dir.)  

Lausanne, EPFL, 2020. 

Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors

G. La Sala / F. Radtke; O. Hantschel (Dir.)  

Lausanne, EPFL, 2020. 

Notch Signaling – a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

D. M. Tardivon / F. Radtke; U. Koch (Dir.)  

Lausanne, EPFL, 2020. 

A single-cell-based identification and characterisation of Aregs, an inhibitory subpopulation of adipose stem and precursor cells

M. Zachara / B. Deplancke (Dir.)  

Lausanne, EPFL, 2020. 

Allosteric regulation and targeting of Bruton’s tyrosine kinase (Btk) in B-cell lymphoma

D. Pereira Duarte / E. Oricchio; O. Hantschel (Dir.)  

Lausanne, EPFL, 2020. 

HIV host genomics in the era of effective antiretroviral therapy

C. A. W. Thorball / J. Fellay; D. Trono (Dir.)  

Lausanne, EPFL, 2020. 

Unequal cleavage of the C. elegans zygote ensures robust embryogenesis

R. Jankele / P. Gönczy (Dir.)  

Lausanne, EPFL, 2020. 

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

C. Melcarne / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2020. 

Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

C. A-L. Contat / E. Meylan (Dir.)  

Lausanne, EPFL, 2020. 

Crosstalk between Drp1 phosphorylation sites during mitochondrial dynamics and metabolic adaptation

M. Valera Alberni / C. Canto Alvarez; E. Meylan (Dir.)  

Lausanne, EPFL, 2020. 

cGAS regulation and activity during genotoxic stress

S-V. Glück / A. Ablasser (Dir.)  

Lausanne, EPFL, 2020. 

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

M. S. Saghafinia / D. Hanahan; G. Ciriello (Dir.)  

Lausanne, EPFL, 2020. 

2019

Analysis of long-range gene regulation at the HoxD locus

A. R. De Carvalho Amândio Lhopitallier / D. Duboule (Dir.)  

Lausanne, EPFL, 2019. 

Hormone receptor signaling in estrogen receptor positive breast cancer

V. Scabia / C. Brisken (Dir.)  

Lausanne, EPFL, 2019. 

Two nanomachines drive evolution in diverse Vibrio species

N. Matthey / M. Blokesch (Dir.)  

Lausanne, EPFL, 2019. 

RADX: A novel single-stranded DNA-binding protein regulating telomere recombination

A-S. Briod / J. Lingner (Dir.)  

Lausanne, EPFL, 2019. 

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

T. Sonntag / J. Feige; E. Meylan (Dir.)  

Lausanne, EPFL, 2019. 

Role of Activin-A signaling in melanoma

O. A. Dubey / D. Constam (Dir.)  

Lausanne, EPFL, 2019. 

A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer

M. C. Donaldson / E. Oricchio (Dir.)  

Lausanne, EPFL, 2019. 

Novel therapeutic strategies targeting the B-cell receptor signaling and antigen presentation pathways in non-Hodgkin lymphoma

E. Battistello / E. Oricchio; G. Ciriello (Dir.)  

Lausanne, EPFL, 2019. 

The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling

T. Didonna / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Mechanistic insights into AMP-activated protein kinase-dependent gene expression

C. Collodet / P. Descombes; B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

R. C. Sommer / S. Cole; A. C. Oates (Dir.)  

Lausanne, EPFL, 2019. 

Adamts18 Function in Mammary Gland Development

D. Ataca / C. Brisken (Dir.)  

Lausanne, EPFL, 2019. 

Identification and characterisation of small-molecule inhibitors targeting STING

S. M. Haag / A. Ablasser (Dir.)  

Lausanne, EPFL, 2019. 

Functional analysis of the telomeric long non-coding RNA TERRA

P. Renck Nunes / J. Lingner (Dir.)  

Lausanne, EPFL, 2019. 

Mitotic chromosome binding predicts transcription factor properties in interphase

M. C. Raccaud / D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Bacterial cell cycle dynamics: size regulation during exponential growth and role of polyphosphate during starvation response

A. L. K. Vanhecke / S. Manley (Dir.)  

Lausanne, EPFL, 2019. 

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

I. Chareyron / A. Wiederkehr; D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

P-Y. J. L. Helleboid / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2019. 

2018

An Exploratory Study On The Functional Significance Of Eosinophil Residency In The Small Intestine Under Homeostatic Conditions

K. Shah / N. Harris (Dir.)  

Lausanne, EPFL, 2018. 

Intestinal helminths modulate the gut microbiome

A. Rapin / N. Harris; J. Rougemont (Dir.)  

EPFL, 2018. 

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

M. Shamseddin / C. Brisken (Dir.)  

Lausanne, EPFL, 2018. 

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

N. E. Schmit / O. Hantschel (Dir.)  

Lausanne, EPFL, 2018. 

Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster

F. Darbellay / D. Duboule (Dir.)  

Lausanne, EPFL, 2018. 

Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis

P. J. Soler Arnedo / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Genomics: a Swiss army knife to fight leprosy

C. Avanzi / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

P. Ginefra / D. Constam (Dir.)  

Lausanne, EPFL, 2018. 

The melanization reaction in Drosophila: More than black or white

J. P. Dudzic / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2018. 

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

M. J. Scholze / P. Gönczy (Dir.)  

Lausanne, EPFL, 2018. 

Integrative approach to analyze the proximal region of the Trichonympha agilis centriole

V. Nemcíková Villímová / P. Gönczy (Dir.)  

EPFL, 2018. 

The role of Snail in non-small cell lung cancer

S. J. Groeneveld / E. Meylan (Dir.)  

Lausanne, EPFL, 2018. 

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

J. L. Scotton / D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Telomeric states in cancer development

J. Majerská / J. Lingner (Dir.)  

Lausanne, EPFL, 2018. 

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors

A. Vancevska / J. Lingner (Dir.)  

Lausanne, EPFL, 2018. 

Development of topological tools for the analysis of biological data

R. Jeitziner / C. Brisken; K. Hess Bellwald (Dir.)  

Lausanne, EPFL, 2018. 

Single live cell monitoring of protein turnover reveals intercellular variability and cell cycle dependence of degradation rates

A. B. Alber / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

The double-edged toxins : how Spiroplasma Ribosome-Inactivating Proteins affect Drosophila melanogaster life history traits

M. G. Garcia Arraez / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2018. 

2017

Role of myeloid cells in mediating protection against parasitic helminth larvae

B. Volpe / N. Harris (Dir.)  

Lausanne, EPFL, 2017. 

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

L. X. M. Lebon / N. Harris (Dir.)  

Lausanne, EPFL, 2017. 

Genomic targets and molecular partners of the chromatin regulator KAP1

A. Kauzlaric / D. Trono (Dir.)  

Lausanne, EPFL, 2017. 

Functional Characterization of Nucleoid Associated Proteins Acting as Global Transcription Factors in Mycobacterium tuberculosis

N. T. Odermatt / S. Cole (Dir.)  

Lausanne, EPFL, 2017. 

Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

L. C. Leal Esteban / D. Constam (Dir.)  

Lausanne, EPFL, 2017. 

Physiological regulation of the CDK16/PCTAIRE-1 protein kinase and its proposed role in the brain

S. N. M. I. Shehata / K. Sakamoto; J. Lingner (Dir.)  

Lausanne, EPFL, 2017. 

Targeting cancer stem cells by T cell engineering

N. P. Desbaillets / J. Hülsken (Dir.)  

Lausanne, EPFL, 2017. 

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

J. Ratajczak / C. Canto Alvarez; J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Rhythmic and clock-dependent chromatin loops regulate circadian gene expression

J. Mermet / F. Naef (Dir.)  

Lausanne, EPFL, 2017. 

Rhythmic modulation of transcriptional burst frequency in circadian gene promoters

D. L. Nicolas / F. Naef; D. M. Suter (Dir.)  

Lausanne, EPFL, 2017. 

KRAB’n’KAP, DNA methylation and epigenetic memory

A. Coluccio / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2017. 

2016

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

C. Jain / F. Radtke (Dir.)  

Lausanne, EPFL, 2016. 

A balancing act between stratification and EMT in cultured human thymic epithelial cells

M. Pluchinotta / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

Structural and functional characterization of the mycobacterial ESX-1 secretion system

Y. Lou / S. Cole (Dir.)  

Lausanne, EPFL, 2016. 

Capturing epidermal stemness

A. Zaffalon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

The Drosophila gut response to infection : a systems approach

M. Bou Sleiman / B. Lemaitre; B. Deplancke (Dir.)  

Lausanne, EPFL, 2016. 

Role of RIP4 in lung adenocarcinoma differentiation

J. Kopparam / E. Meylan (Dir.)  

Lausanne, EPFL, 2016. 

Identification of genetic interactors of ypa2 in Schizosaccharomyces pombe

M. Moraru / V. Simanis (Dir.)  

Lausanne, EPFL, 2016. 

Folding and Endocytosis of Anthrax Toxin Receptors

S. E. Friebe / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2016. 

Development of microfluidic devices for chemotaxis of primary stem cells

Z. Tatárová / J. Hülsken; S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

AMP-activated protein kinase : strategies for activation and downstream target identification

S. T. S. Ducommun / K. Sakamoto; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver

J. A. Sobel / F. Naef (Dir.)  

Lausanne, EPFL, 2016. 

Circadian rhythm and cell cycle : two synchronized processes

R. Cannavo / F. Naef (Dir.)  

Lausanne, EPFL, 2016. 

Mechanisms of centrosome separation in C. elegans

A. De Simone / P. Gönczy; F. Naef (Dir.)  

Lausanne, EPFL, 2016. 

2015

The chromatin remodeller Chd7 and the calcium ATPase Serca2 – adding new facets to the role of Notch in Hematopoiesis and T-ALL

M. Coersmeyer / F. Radtke (Dir.)  

Lausanne, EPFL, 2015. 

Mechanisms underlying cell-fate determination in the mammary gland development

D. Buric / C. Brisken (Dir.)  

Lausanne, EPFL, 2015. 

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

L. A. E. Lemaire / D. Constam; A. Grapin-Botton (Dir.)  

Lausanne, EPFL, 2015. 

Lead Optimisation of a Novel Small Molecule Notch Inhibitor

V. Reinmüller / F. Radtke; J. Zhu (Dir.)  

Lausanne, EPFL, 2015. 

Regulation of the mRNA silencing activity of Bicaudal-C

F. U. Bernet / D. Constam (Dir.)  

Lausanne, EPFL, 2015. 

Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

W. B. Chng / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2015. 

GLUT1 and GLUT3 in non-small cell lung cancer

M. J. Masin / E. Meylan (Dir.)  

Lausanne, EPFL, 2015. 

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

J. Bürgi / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2015. 

Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

N. Pennese / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2015. 

2014

Regulatory T cells modulate the intestinal immune response in homeostasis and infection

I. Mosconi / N. Harris (Dir.)  

Lausanne, EPFL, 2014. 

MicroRNA 21 is a novel oncogene in Notch1-driven acute lymphoblastic T cell leukemia

F. Junker / F. Radtke (Dir.)  

Lausanne, EPFL, 2014. 

Towards uncovering novel functions of Aurora A kinase in C. elegans embryos

C. Gentili / P. Gönczy (Dir.)  

Lausanne, EPFL, 2014. 

c-Myc is essential for melanoma formation and metastasis

M. Armaro / F. Beermann; F. Radtke (Dir.)  

Lausanne, EPFL, 2014. 

Assessing the role of Hes1 and identification of target genes in human and murine T-ALL

S. Wirth / F. Radtke (Dir.)  

Lausanne, EPFL, 2014. 

Mechanistic aspects of DNA uptake in naturally competent Vibrio cholerae

P. M. Seitz / M. Blokesch (Dir.)  

Lausanne, EPFL, 2014. 

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

A. E. Moor / M. Aguet (Dir.)  

Lausanne, EPFL, 2014. 

Benzothiazinones: from a new lead to new combination therapies against Mycobacterium tuberculosis

B. Lechartier / S. Cole; L. P. Nicod (Dir.)  

Lausanne, EPFL, 2014. 

Mechanisms of differential centriole inheritance in C. elegans

L. von Tobel / P. Gönczy (Dir.)  

Lausanne, EPFL, 2014. 

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Z. P. Spiró / P. Gönczy (Dir.)  

Lausanne, EPFL, 2014. 

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

C. Urech / J. Huelsken (Dir.)  

Lausanne, EPFL, 2014. 

The role of recruited bone-marrow derived mesenchymal stem cells in the establishment of the tumor stroma and a growth-supportive environment

J-P. Abbühl / J. Huelsken (Dir.)  

Lausanne, EPFL, 2014. 

The useful gate-crasher : molecular interactions between Drosophila and Spiroplasma

J. C. Paredes Escobar / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2014. 

Mechanism and Function of S-palmitoylation in Capillary Morphogenesis Gene 2

S. Blaskovic / G. van der Goot (Dir.)  

Lausanne, EPFL, 2014. 

In-Depth Analysis of Mutations in Hyaline Fibromatosis Syndrome (HFS)

S. Yan / G. van der Goot (Dir.)  

Lausanne, EPFL, 2014. 

NMDAR signaling in cancer : regulation by a polymorphic modifier gene and the tumor microenvironment

L. Li / D. Hanahan (Dir.)  

Lausanne, EPFL, 2014. 

Human telomerase oligomerization and activity of hTERT mutants

A. Christen / J. Lingner (Dir.)  

Lausanne, EPFL, 2014. 

Context-specific regulation of BMAL1 target genes during the circadian rhythm in mouse

J. C. Cajan / F. Naef; B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Spatio-temporal synchronization of biological oscillators

J. Bieler / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

Antibiotic-Induced Killing and Persistence of Mycobacteria

E. Gelman / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2014. 

2013

Notch Signaling in Pigment Cells and Generation of Mouse Models for Ocular Diseases

B. Sarode / F. Beermann; F. Radtke (Dir.)  

Lausanne, EPFL, 2013. 

Mechanisms of Hoxd gene regulation during the development and evolution of the intestinal caecum

S. Delpretti Anex / D. Duboule (Dir.)  

Lausanne, EPFL, 2013. 

Regulatory Switches Underlie Hoxd Gene Activation in Tetrapod Limbs

G. Andrey / D. Duboule (Dir.)  

Lausanne, EPFL, 2013. 

Polycomb Recruitment and Targeting in Mammals

P. Schorderet / D. Duboule (Dir.)  

Lausanne, EPFL, 2013. 

An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits

N. Lonfat / D. Duboule (Dir.)  

Lausanne, EPFL, 2013. 

RNA-Protein interactions at AU-rich elements

R. Pauchard-Batschulat / L. Kühn (Dir.)  

Lausanne, EPFL, 2013. 

Novel strategies for the development of anti-tuberculosis compounds

M. Zhang / S. Cole (Dir.)  

Lausanne, EPFL, 2013. 

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

S. Chakrabarti / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2013. 

Role and regulation of the melanization reaction in Drosophila immune response

O. Binggeli / B. Lemaitre (Dir.)  

Lausanne, EPFL, 2013. 

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

L. Grolimund / J. Lingner (Dir.)  

Lausanne, EPFL, 2013. 

Involvement of the THO complex subunit Thp2 in telomere stability

J. Crittin / J. Lingner (Dir.)  

Lausanne, EPFL, 2013. 

Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles

L. Symul / F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

Quantitative analysis and mathematical modeling of polarity establishment in C. elegans embryos

S. Blanchoud / P. Gönczy; F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

2012

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

C. Cortijo / A. Grapin-Botton (Dir.)  

Lausanne, EPFL, 2012. 

Towards understanding HsSAS-6, a key player in centriole duplication

D. Keller / P. Gönczy (Dir.)  

Lausanne, EPFL, 2012. 

Activin Signalling in Human Melanoma Cells

S. E. Kallioinen / D. Constam (Dir.)  

Lausanne, EPFL, 2012. 

Identification of a Novel Wnt Inhibitor

E. Susanto / J. Huelsken (Dir.)  

Lausanne, EPFL, 2012. 

Asymmetric Cell Division in the Skin

W-H. Fan / J. Hülsken (Dir.)  

Lausanne, EPFL, 2012. 

Isolation and Characterisation of Regulators of the Septation Initiation Network Regulators in Fission Yeast

A. Goyal / V. Simanis (Dir.)  

Lausanne, EPFL, 2012. 

Isolation and Analysis of Regulators Coordinating the Nuclear Cycle with Cytokinesis in Schizosaccharomyces Pombe

E. Lattmann / V. Simanis (Dir.)  

Lausanne, EPFL, 2012. 

Telomeric Repeat Containing RNAs and the Response to Telomere Deprotection in Saccharomyces Cerevisiae

A. B. Panza / J. Lingner (Dir.)  

Lausanne, EPFL, 2012. 

2011

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

C. Greggio / A. Grapin-Botton (Dir.)  

Lausanne, EPFL, 2011. 

Identification and Preclinical Validation of Novel Inhibitors of the Notch Pathway

R. Lehal / F. Radtke (Dir.)  

Lausanne, EPFL, 2011. 

The Cell Differentiation Status Influences the Outcome of Notch-Induced Malignancy

C. Poisson / F. Radtke (Dir.)  

Lausanne, EPFL, 2011. 

The Intestinal Epithelium : Role of Notch Signaling

L. Pellegrinet / F. Radtke (Dir.)  

Lausanne, EPFL, 2011. 

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

N. Wiedemann / M. Aguet (Dir.)  

Lausanne, EPFL, 2011. 

The Role of Nodal Processing in Pluripotent Progenitors

A. Dietze / D. Constam (Dir.)  

Lausanne, EPFL, 2011. 

Asymmetric Spindle Positioning and Intracellular Trafficking in C. Elegans Embryos

K. Thyagarajan / P. Gönczy (Dir.)  

Lausanne, EPFL, 2011. 

On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver

G. Rey / F. Naef (Dir.)  

Lausanne, EPFL, 2011. 

Insight into the Regulation of Telomerase Access to Telomeres by Shelterin Proteins

E. Aritonovska / J. Lingner (Dir.)  

Lausanne, EPFL, 2011. 

Mutual Inhibition Between the Anaphase-promoting Complex and the Spindle Assembly Checkpoint in C. Elegans Embryos

A. Bezler / P. Gönczy (Dir.)  

Lausanne, EPFL, 2011.