EDCB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Computational and Quantitative Biology.

2025

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

H. H. E. Schede / G. D’Angelo; G. La Manno (Dir.)  

Lausanne, EPFL, 2025. 

Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery

D. Cois / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Mapping Brain Morphology with Micro-CT and Topological Data Analysis: From Drosophila to General Applications

S. S. Bourgeat / B. McCabe; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2025. 

Learning the language of the genome: AI- and data-driven decoding of genetic variants and disease mechanisms

A. Saadat Varnosfaderanii / J. Fellay (Dir.)  

Lausanne, EPFL, 2025. 

Light-directed evolution of dynamic biological systems

V. Gligorovski / S. J. Rahi (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging social media data and large language models for understanding public health behaviours in the context of infectious diseases and vaccination

L. Espinosa Montalbán / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Investigation of the bone marrow niche in clonal hematopoiesis and myelodysplastic syndrome

M. Kholmatov / B. Deplancke; J. Zaugg (Dir.)  

Lausanne, EPFL, 2025. 

Transcription Factor Target Search on Chromatin via Electrostatic Interactions

S. Sakong / D. Suter; B. Fierz (Dir.)  

Lausanne, EPFL, 2025. 

Non-equilibrium control of biomolecular condensates

A. Shelest / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging chromatin modules to explore the impact of regulatory variation on disease

O. Pushkarev / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

SPAD Image Sensors with Embedded Intelligence

Y. Lin / E. Charbon; C. Bruschini (Dir.)  

Lausanne, EPFL, 2025. 

Revealing and exploiting coevolution through protein language models

D. Sgarbossa / A-F. R. Bitbol (Dir.)  

Lausanne, EPFL, 2025. 

The Regulation of Transcription Factors Binding Site Occupancies by Their Concentrations

R. Mizeret / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Dynamics and Coordination of Protein Synthesis and Protein Decay in Mammalian Cells

B. J. C. A. H. Martin / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Computational design of complex protein folds and soluble analogs of membrane proteins

C. A. Goverde / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

2024

Characterisation of EIF5A perturbations on ribosome dynamics with single-molecule imaging

I. Lamberti / F. Naef (Dir.)  

Lausanne, EPFL, 2024. 

Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

A. Theodoropoulou / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2024. 

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

A. R. Lederer / G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

Predicting protein interactions using geometric deep learning on protein surfaces

F. Sverrisson / B. E. Ferreira De Sousa Correia; M. Bronstein (Dir.)  

Lausanne, EPFL, 2024. 

Coarse grain modelling of DNA self-assembly over multiple scales

V. Caroprese / M. Bastings (Dir.)  

Lausanne, EPFL, 2024.