Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

A. De Masi; N. Zanou; K. Strotjohann; D. Lee; T. I. Lima et al. 

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

S. Choi; J-G. Kang; Y. T. H. Tran; S-H. Jeong; K-Y. Park et al. 

Embracing cancer complexity: Hallmarks of systemic disease

C. Swanton; E. Bernard; C. Abbosh; F. Andre; J. Auwerx et al. 

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Y. Kim; K-Y. Jung; Y. H. Kim; P. Xu; B. E. Kang et al. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Cellpose training data and scripts from “Inhibition of CERS1 in aging skeletal muscle exacerbates age-related muscle impairments”

M. Wohlwend; O. Burri; J. Auwerx 

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

X. Li; J-D. H. Morel; G. Benegiamo; J. G. A. Poisson; A. Bachmann et al. 

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

M. Wohlwend; P-P. U. Laurila; L. Goeminne; T. Imamura de Lima; A. Lalou et al. 

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

T. Y. Li; Q. Wang; A. W. Gao; X. Li; Y. Sun et al. 

Cyclo(His-Pro): A further step in the management of steatohepatitis

A. De Masi; X. Li; D. Lee; J. Jeon; Q. Wang et al. 

Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response

F. Xu; J. Ziebarth; L. J. E. Goeminne; J. Gao; E. G. Williams et al. 

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

M. Girotra; Y-H. Chiang; M. Charmoy; P. Ginefra; H. C. Hope et al. 

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

A. Park; K-e. Kim; I. Park; S. H. Lee; K-Y. Park et al. 

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

T. I. Lima; P-P. Laurila; M. Wohlwend; J. D. Morel; L. J. E. Goeminne et al. 

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

D. Chanda; T. Thoudam; I. S. Sinam; C. W. Lim; M. Kim et al. 

Mitochondria: A “pacemaker”for species-specific development

Y. J. Liu; J. Auwerx 

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

E. Yildiz; G. El Alam; A. Perino; A. Jalil; P-D. Denechaud et al. 

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

N. Kitamura; S. Zhang; J-D. Morel; U. Nagano; T. Taworntawat et al. 

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

G. Benegiamo; G. V. G. von Alvensleben; S. Rodriguez-Lopez; L. J. E. Goeminne; A. M. Bachmann et al. 

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

J. -D. Morel; M. B. Sleiman; T. Y. Li; G. von Alvensleben; A. M. Bachmann et al. 

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

J. English; J. Orofino; C. T. Cederquist; I. Paul; H. Li et al. 

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

Y. Liu; M. Kimura; S. Rodriguez-Lopez; A. M. L. Scantlebery; K. Strotjohann et al. 

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Y. Liu; A. M. L. Scantlebery; K. Strotjohann; S. Rodriguez-Lopez; X. Li et al. 

CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome.

D. Lee; J. Jeon; S. Baek; O. Park; X. Li et al. 

CycloZ reduces inflammation in bleomycin-induced idiopathic pulmonary fibrosis model mice.

S. Baek; D. Lee; J. Jeon; O. Park; X. Li et al. 

Mitophagy in human health, ageing and disease

A. Picca; J. Faitg; J. Auwerx; L. Ferrucci; D. D’Amico 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

J. Auwerx; A. J. L. Mottis; M. Nelson 

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

B. E. Kang; A. Park; H. Yang; Y. Jo; T. G. Oh et al. 

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

T. Yoshizawa; Y. Sato; S. U. Sobuz; T. Mizumoto; T. Tsuyama et al. 

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

P-P. Laurila; M. Wohlwend; T. I. de Lima; P. Luan; S. Herzig et al. 

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

T. Y. Li; A. W. Gao; X. Li; H. Li; Y. J. Liu et al. 

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

G. Benegiamo; M. B. Sleiman; M. Wohlwend; S. Rodriguez-Lopez; L. J. E. Goeminne et al. 

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

H. Li; A. Perino; Q. Huang; G. V. G. Von Alvensleben; A. Banaei-Esfahani et al. 

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

W. K. L. Doolittle; S. Park; S. G. Lee; S. Jeong; G. Lee et al. 

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

N. Bresciani; H. Demagny; V. Lemos; F. Pontanari; X. Li et al. 

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

M. Bou Sleiman; S. Roy; A. W. Gao; M. C. Sadler; G. V. G. von Alvensleben et al. 

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

A. Mottis; T. Y. Li; G. El Alam; A. Rapin; E. Katsyuba et al. 

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

S. N. Fox; L. J. McMeekin; C. H. Savage; K. L. Joyce; S. M. Boas et al. 

Genetic background and sex control the outcome of high-fat diet feeding in mice

A. M. Bachmann; J-D. Morel; G. El Alam; S. Rodríguez-López; T. Imamura de lima et al. 

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D’Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose et al. 

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

A. Sanchez-Navarro; M. A. Martinez-Rojas; A. Albarran-Godinez; R. Perez-Villalva; J. Auwerx et al. 

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

A. W. Gao; G. El Alam; A. Lalou; T. Y. Li; M. Molenaars et al. 

The mouse metallomic landscape of aging and metabolism

J-D. Morel; L. Sauzeat; L. J. E. Goeminne; P. Jha; E. Williams et al. 

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

P-P. Laurila; P. Luan; M. Wohlwend; N. Zanou; B. Crisol et al. 

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

L. Morató; S. Astori; I. Zalachoras; J. Rodrigues; S. Ghosal et al. 

ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID MODELS OF STEATOHEPATITIS

Y. Liu; M. Kimura; A. Vijayakumar; E. Murakami; T. Takebe et al. 

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

A. De Masi; Xiaoxu Li; Qi Wang; A. Mottis; A. Rapin et al. 

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

G. Benegiamo; G. Von Alvensleben; Y. Liu; S. Rodriguez-Lopez; A. Bachmann et al. 

Pleiotropic effects of mitochondria in aging

T. Lima; T. Y. Li; A. Mottis; J. Auwerx 

The role of nicotinamide riboside metabolism in pancreatic beta cells

Products and methods for promoting myogenesis

M. Wohlwend; J. Auwerx; U. Wisløff; J. B. Moreira 

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

N. Zanou; H. Dridi; S. Reiken; T. I. de Lima; C. Donnelly et al. 

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

M. Wohlwend; P-P. Laurila; K. William; M. Romani; T. Lima et al. 

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

G. C. Addicks; H. Zhang; D. Ryu; G. Vasam; A. E. Green et al. 

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

T. Hu; S. K. Shukla; E. Vernucci; C. He; D. Wang et al. 

Phalloidin Staining of Actin Filaments for Visualization of Muscle Fibers in Caenorhabditis elegans

M. Romani; J. Auwerx 

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

S. Roy; M. B. Sleiman; P. Jha; J. F. Ingels; C. J. Chapman et al. 

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D’Amico; P. A. Andreux; G. Dunngalvin; T. Kern et al. 

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

E. B. M. Nascimento; M. P. B. Moonen; C. M. E. Remie; K. Gariani; J. A. Jorgensen et al. 

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

P. Luan; D. D’Amico; P. A. Andreux; P-P. Laurila; M. Wohlwend et al. 

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

L. G. Noriega; Z. Melo; R. D. Rajaram; A. Mercado; A. R. Tovar et al. 

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

S. G. Kang; M. J. Choi; S-B. Jung; H. K. Chung; J. Y. Chang et al. 

A platform for experimental precision medicine: The extended BXD mouse family

D. G. Ashbrook; D. Arends; P. Prins; M. K. Mulligan; S. Roy et al. 

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Y. Shi; W. Su; L. Zhang; C. Shi; J. Zhou et al. 

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Y. L. N. Abril; I. R. Fernandez; J. Y. Hong; Y-L. Chiang; D. A. Kutateladze et al. 

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

M. Romani; V. Sorrentino; C. Oh; H. Li; T. Imamura de Lima et al. 

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

H. Zhou; S. Zhou; Y. Shi; Q. Wang; S. Wei et al. 

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

X. Ming; A. C. K. Chung; D. Mao; H. Cao; B. Fan et al. 

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

A. Faivre; E. Katsyuba; T. Verissimo; M. Lindenmeyer; R. D. Rajaram et al. 

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

D. D’Amico; P. A. Andreux; P. Valdes; A. Singh; C. Rinsch et al. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids

P-P. Laurila; J. Auwerx 

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

A. L. Rocha; T. I. de Lima; G. P. de Souza; R. O. Correa; D. L. Ferrucci et al. 

Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

D. Patoli; F. Mignotte; V. Deckert; A. Dusuel; A. Dumont et al. 

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

M. B. Sleiman; P. Jha; R. Houtkooper; R. W. Williams; X. Wang et al. 

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

A. Nakamura; Y. Yokoyama; K. Tanaka; G. Benegiamo; A. Hirayama et al. 

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models

R. N. Hegde; A. Chiki; L. Petricca; P. Martufi; N. Arbez et al. 

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

L-J. Du; J-Y. Sun; W-C. Zhang; Y-L. Wang; H. Zhu et al. 

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

H. Yoon; J. B. Spinelli; E. Zaganjor; S. J. Wong; N. J. German et al. 

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

D. Brigger; C. Riether; R. van Brummelen; K. I. Mosher; A. Shiu et al. 

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

C. M. E. Remie; K. H. M. Roumans; M. P. B. Moonen; N. J. Connell; B. Havekes et al. 

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

J. S. Moon; L. J. E. Goeminne; J. T. Kim; J. W. Tian; S-H. Kim et al. 

Confounding factors from inducible systems for spatiotemporal gene expression regulation

R. C. I. Wuest; R. H. Houtkooper; J. Auwerx 

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

R. Reynaud-Dulaurier; G. Benegiamo; E. Marrocco; R. Al-Tannir; E. M. Surace et al. 

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

K. Williams; L. R. Ingerslev; J. Bork-Jensen; M. Wohlwend; A. N. Hansen et al. 

Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models

B. A. Harlan; K. M. Killoy; M. Pehar; L. Liu; J. Auwerx et al. 

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

S. Haemmig; D. Yang; X. Sun; D. Das; S. Ghaffari et al. 

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

C. A. Stoyas; D. D. Bushart; P. M. Switonski; J. M. Ward; A. Alaghatta et al. 

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

A. E. Dikalova; A. Pandey; L. Xiao; L. Arslanbaeva; T. Sidorova et al. 

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1

T. Arsiwala; J. Pahla; L. J. van Tits; L. Bisceglie; D. S. Gaul et al. 

NCoR1 Protects Mice From Dextran Sodium Sulfate Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult

E. Mennillo; X. Yang; M. Paszek; J. Auwerx; C. Benner et al. 

A conserved role of CBP/p300 in mitochondrial stress response and longevity

J. Auwerx; T. Li 

Mouse Systems Genetics as a Prelude to Precision Medicine

H. Li; J. Auwerx 

NAD(+) homeostasis in health and disease

E. Katsyuba; M. Romani; D. Hofer; J. Auwerx 

Metabolic rescue of muscle and muscle stem cells in muscle disease

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

H. B. Atakan; K. S. Hof; M. Cornaglia; J. Auwerx; M. A. M. Gijs 

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

R. P. J. Bevers; M. Litovchenko; A. Kapopoulou; V. S. Braman; M. R. Robinson et al. 

Identifying gene function and module connections by the integration of multispecies expression compendia

H. Li; D. Rukina; F. P. A. David; T. Y. Li; C-M. Oh et al. 

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

D. C. Hofer; G. Zirkovits; H. J. Pelzmann; K. Huber; A. R. Pessentheiner et al. 

A biosensor for measuring NAD(+) levels at the point of care

Q. Yu; N. Pourmandi; L. Xue; C. Gondrand; S. Fabritz et al. 

Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis

T. I. Lima; D. S. P. S. F. Guimaraes; A. G. Oliveira; H. Araujo; C. H. G. Sponton et al. 

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

M. E. Perez-Munoz; A. M. McKnite; E. G. Williams; J. Auwerx; R. W. Williams et al. 

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; E. Katsyuba et al. 

Nuclear receptor corepressor 1 represses cardiac hypertrophy

C. Li; X-N. Sun; B-Y. Chen; M-R. Zeng; L-J. Du et al. 

The gut microbiota influences skeletal muscle mass and function in mice

S. Lahiri; H. Kim; I. Garcia-Perez; M. M. Reza; K. A. Martin et al. 

Cross-species functional modules link proteostasis to human normal aging

A. Komljenovic; H. Li; V. Sorrentino; Z. Kutalik; J. Auwerx et al. 

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson et al. 

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

D. Dahlmans; A. Houzelle; P. Andreux; X. Wang; J. A. Jorgensen et al. 

Autophagy regulates lipid metabolism through selective turnover of NCoR1

T. Saito; A. Kuma; Y. Sugiura; Y. Ichimura; M. Obata et al. 

Niacin: an old lipid drug in a new NAD(+) dress

M. Romani; D. C. Hofer; E. Katsyuba; J. Auwerx 

Mild inborn errors of metabolism in commonly used inbred mouse strains

J. Leandro; S. Violante; C. A. Argmann; J. Hagen; T. Dodatko et al. 

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

N. Vannini; V. Campos; M. Girotra; V. Trachsel; S. Rojas-Sutterlin et al. 

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo

X. Wan; L. Liu; P. Zhou; X. Hui; Q. He et al. 

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip

D. Migliozzi; M. Cornaglia; L. Mouchiroud; V. Uhlmann; M. A. Unser et al. 

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

A. Faivre; A. Mottis; R. D. Rajaram; D. Legouis; M. Lindenmeyer et al. 

Inhibition of Mitophagy Triggers Classical Activation of Macrophages

D. Patoli; V. Deckert; A. Rieu; A. Dusuel; A. Jalil et al. 

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; J. Auwerx et al. 

Mitocellular communication: Shaping health and disease

A. Mottis; S. Herzig; J. Auwerx 

The virtuous cycle of human genetics and mouse models in drug discovery

J. H. Nadeau; J. Auwerx 

Systems genetics approaches to probe gene function

Methods of treating or preventing an aging-related disease

D. D’Amico; J. Auwerx 

De novo NAD(+) synthesis enhances mitochondrial function and improves health

E. Katsyuba; A. Mottis; M. Zietak; F. De Franco; V. van der Velpen et al. 

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

E. G. Williams; Y. Wu; W. Wolski; J. Y. Kim; J. Lan et al. 

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

M. Ruiz; M. Begou; N. Launay; P. Ranea-Robles; P. Bianchi et al. 

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

H. Li; X. Wang; D. Rukina; Q. Huang; T. Lin et al. 

A microfluidic array for high-content screening at whole-organism resolution

D. Migliozzi; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. A. M. Gijs 

Mitochondrial stress signalling and its impacts on physiology

Plasma and liver lipid species as biomarkers of fatty liver

P. Jha; J. Auwerx 

Methods of treating amyloid-beta peptide diseases

J. Auwerx; V. Sorrentino; L. Mouchiroud 

PPAR delta Promotes Running Endurance by Preserving Glucose

W. Fan; W. Waizenegger; C. S. Lin; V. Sorrentino; M-X. He et al. 

A multiscale study of the role of dynamin in the regulation of glucose uptake

R. Trouillon; M. C. Letizia; K. J. Menzies; L. Mouchiroud; J. Auwerx et al. 

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S. Preston; P. K. Korhonen; L. Mouchiroud; M. Cornaglia; S. L. Mcgee et al. 

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

H. K. Chung; D. Ryu; K. S. Kim; J. Y. Chang; Y. K. Kim et al. 

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

H. Yang; H. Zhou; L. Zhuang; J. Auwerx; K. Schoonjans et al. 

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

S. Chen; W. Lu; M-F. Yueh; E. Rettenmeier; M. Liu et al. 

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

X. Wang; J. Auwerx 

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondria! metabolism

D. Dahlmans; A. Houzelle; P. Andreux; J. A. Jorgensen; X. Wang et al. 

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

K. Kim; D. Ryu; P. Dongiovanni; L. Ozcan; S. Nayak et al. 

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

V. Sorrentino; M. Romani; L. M. Ouchiroud; J. S. Beck; H. Zhang et al. 

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

E. Ciarlo; T. Heinonen; J. Lugrin; H. Acha-Orbea; D. Le Roy et al. 

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

H. B. Atakan; M. Cornaglia; L. Mouchiroud; J. Auwerx; M. Gijs 

Chromatin remodeling factor integrates responses against nuclear and mitochondrial stress

O. Matilainen; P. M. Quiros; J. Auwerx 

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

D. D’Amico; V. Sorrentino; J. Auwerx 

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

H. Zhang; K. Menzies; J. Auwerx; D. Ryu 

The effects of mitochondrial- and histone stress on the C. elegans transcriptome

O. J. Matilainen; M. Bou Sleiman; P. Moral Quiros; S. M. D. A. Garcia; J. Auwerx