BRISKEN LAB Hormones : Keys to Breast Cancer Prevention and Therapy
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Selected Publications
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2022/09/Patrik_Nature-384x216.jpg)
Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence
Patrick Aouad – Nature Communications volume 13, Article number: 4975 (2022)
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Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor
Valentina Scabia – Nature Communications volume 13, Article number: 3127 (2022)
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2022/03/EMM_Graphical_Abstract_v6_Twitter-FdM-384x216.jpg)
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation
Fabio De Martino – EMBO Mol Med (2021)13:e14314
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2021/03/GSflomos1.jpg)
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
George Sflomos – EMBO Molecular Medicine. 5 March 2021
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2021/03/Dalya_Nature1.jpg)
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Dalya Ataca – Nature Communications. 2020-03-26
![ImageJ=1.52p](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2021/03/Cagnet_Nature-384x216.jpg)
Oestrogen receptor alpha AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
Stéphanie Cagnet – Nature Communications. 2018-11-09
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2019/11/PublicationRJ-2_new-384x216.jpg)
Two-Tier Mapper, an unbiased topology-based clustering method for enhanced global gene expression analysis
Rachel Jeitziner – Bioinformatics 2019-02-07
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2019/11/PublicationMF_new-384x216.jpg)
Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions
Maryse Fiche – The Journal of Pathology Dec 27 2018
![](https://www.epfl.ch/labs/brisken-lab/wp-content/uploads/2019/11/Picture1-16x9-384x216.jpg)
A preclinical Model for ERa-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
George Sflomos – Cancer Cell, 14 March 2016
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