Understanding hormone signaling and its risk on estrogen receptor-positive breast cancer

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

T. Geukens; M. De Schepper; W. van den Bogaert; K. Van Baelen; M. Maetens et al. 

Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?

R. L. Flaherty; G. Sflomos; C. Brisken 

Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer

M. Bacci; N. Lorito; A. Smiriglia; A. Subbiani; F. Bonechi et al. 

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Using deep learning-based approaches to characterise ageing in different tissue components of normal breast tissue of women with different risk of developing breast cancer

S. Y. Chen; M. P. Centeno; G. Verghese; G. Booker; I. Wall et al. 

Tumor dormancy: EMT beyond invasion and metastasis

P. Aouad; H. M. Quinn; A. Berger; C. Brisken 

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma

G. Sflomos; N. Schaumann; M. Christgen; H. Christgen; S. Bartels et al. 

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

A. Seifinejad; M. Ramosaj; L. Shan; S. Li; M-L. Possovre et al. 

TGF beta-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression

S. V. Gibson; E. Tomas Bort; L. Rodriguez-Fernandez; M. D. Allen; J. J. Gomm et al. 

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

C. Ronchi; C. Brisken 

Method for hormone or drug screening in a tissue sample

Y. Zhang; C. Merten; C. Brisken 

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

P. Aouad; Y. Zhang; F. De Martino; C. Stibolt; S. Ali et al. 

RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer

J. Staaf; J. Hakkinen; C. Hegardt; L. H. Saal; S. Kimbung et al. 

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

V. Scabia; A. Ayyanan; F. De Martino; A. Agnoletto; L. Battista et al. 

Role of the androgen receptor in the human breast epithelium

Estrogen receptor signaling in the human breast epithelium

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

G. Sflomos; K. Schipper; T. Koorman; A. Fitzpatrick; S. Oesterreich et al. 

Abstract 2993: Intraductal xenografts model ERα-positive invasive lobular carcinoma of the breast

G. Sflomos; L. Battista; P. Aouad; F. De Martino; V. Scabia et al. 

Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation

M. Shamseddin; F. De Martino; C. Constantin; V. Scabia; A-S. Lancelot et al. 

Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features

Q. Juppet; F. De Martino; E. Marcandalli; M. Weigert; O. Burri et al. 

Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1

G. Sflomos; L. Battista; P. Aouad; F. De Martino; V. Scabia et al. 

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

R. Siersbæk; V. Scabia; S. Nagarajan; I. Chernukhin; E. K. Papachristou et al. 

A novel culture method that sustains ER alpha signaling in human breast cancer tissue microstructures

A. L. Cartaxo; M. F. Estrada; G. Domenici; R. Roque; F. Silva et al. 

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

C. Koch; A. Kuske; S. A. Joosse; G. Yigit; G. Sflomos et al. 

90 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer

C. Brisken; V. Scabia 

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

D. Ataca; P. Aouad; C. Constantin; C. Laszlo; M. Beleut et al. 

Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium

L. Gagniac; M. Rusidze; F. Boudou; S. Cagnet; M. Adlanmerini et al. 

miR363-3p mediates maintenance of breast cancer stem cells (BCSCs) and predicts resistance to neoadjuvant chemotherapy and disease recurrence

S. Renaud; A. Stravodimou; M. Fiche; I. Xenarios; S. Valentina et al. 

Variably Scaled Kernels Improve Classification of Hormonally-Treated Patient-Derived Xenografts

F. Marchetti; F. De Martino; M. Shamseddin; S. De Marchi; C. Brisken 

A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

C. F. Laszlo; J. P. Montoya; M. Shamseddin; F. De Martino; A. Beguin et al. 

C/EBP alpha mediates the growth inhibitory effect of progestins on breast cancer cells

A. Silvina Nacht; R. Ferrari; R. Zaurin; V. Scabia; J. Carbonell-Caballero et al. 

Two-Tier Mapper, an unbiased topology-based clustering method for enhanced global gene expression analysis

R. Jeitziner; M. Carrière; J. Rougemont; S. Oudot; K. Hess et al. 

Novel human cell line xenograft models of ER alpha-positive metastatic invasive lobular breast carcinoma as pre-clinical platforms for validating candidate genetic drivers

N. Tasdemir; J. Scott; J. Laotche; W. Hou; E. A. Bossart et al. 

Investigating cortactin as a genetic driver of disease progression in invasive lobular carcinoma

N. Tasdemir; M. J. Sikora; L. Zhu; K. M. Levine; J. Scott et al. 

Adamts18 Function in Mammary Gland Development

Hormone receptor signaling in estrogen receptor positive breast cancer

Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions

M. Fiche; V. Scabia; P. Aouad; L. Battista; A. Treboux et al. 

Oestrogen receptor alpha AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

S. Cagnet; D. Ataca; G. Sflomos; P. Aouad; S. Schuepbach-Mallepell et al. 

Investigating genetic drivers of disease progression in invasive lobular carcinoma

N. Tasdemir; M. Sikora; L. Zhu; K. Levine; A. Basudan et al. 

Development of topological tools for the analysis of biological data

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

The challenges of modeling hormone receptor-positive breast cancer in mice

B. C. Özdemir; G. Sflomos; C. Brisken 

Applying Whole Organ Clearing Techniques To Spinal Cord Injury: A Survey Of Techniques

N. Cho; L. Batti; S. Pages; T. Laroche; O. Burri et al. 

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

A. L. George; C. A. Boulanger; L. H. Anderson; S. Cagnet; C. Brisken et al. 

Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium

D. Buric; C. Brisken 

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

D. Ataca; M. Caikovski; A. Piersigilli; A. Moulin; C. Benarafa et al. 

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

G. Sflomos; V. Dormoy; T. Metsalu; R. Jeitziner; L. Battista et al. 

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

L. E. Dobrolecki; S. D. Airhart; D. G. Alferez; S. Aparicio; F. Behbod et al. 

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

C. Brisken; K. Hess Bellwald; R. Jeitziner 

Endocrine hormones and local signals during the development of the mouse mammary gland

C. Brisken; D. Ataca 

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

R. D. Rajaram; D. Buric; M. Caikovski; A. Ayyanan; J. Rougemont et al. 

An Ex vivo Model to Study Hormone Action in the Human Breast

G. Sflomos; M. Shamsheddin; C. Brisken 

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

M-G. Procopio; C. Laszlo; D. Al Labban; D. E. Kim; P. Bordignon et al. 

Mechanisms underlying cell-fate determination in the mammary gland development

2013 : Etat des lieux – Services & Collections (Sciences de la vie – Bibliothèque de l’EPFL)

P. Devaud; I. Kratz 

Reply to Is progesterone a neutral or protective factor for breast cancer?

C. Brisken 

2012 : Etat des lieux – Services & Collections (Sciences de la vie – Bibliothèque de l’EPFL)

P. Devaud; I. Kratz 

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

C. Brisken 

A new Achilles Heel in breast cancer?

G. Sflomos; C. Brisken 

Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

A. M. Soto; C. Brisken; C. Schaeberle; C. Sonnenschein 

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

T. Tanos; G. Sflomos; P. C. Echeverria; A. Ayyanan; M. Gutierrez et al. 

Paracrine signaling by progesterone

R. D. Rajaram; C. Brisken 

ER and PR signaling nodes during mammary gland development

T. Tanos; L. Jimenez Rojo; P. Echeverria; C. Brisken 

ERBIN is a new SARA-interacting protein: Competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

G. Sflomos; E. Kostaras; E. Panopoulou; N. Pappas; A. Kyrkou et al. 

High hopes for RANKL: will the mouse model live up to its promise?

T. Tanos; C. Brisken 

Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

A. Ayyanan; O. Laribi; S. Schuepbach-Mallepell; C. Schrick; M. Gutierrez et al. 

ID4 regulates mammary gland development by suppressing p38MAPK activity

J. Dong; S. Huang; M. Caikovski; S. Ji; A. Mcgrath et al. 

miR-148b is a major coordinator in a relapse-associated miR signature in breast tumors

D. Cimino; C. D. Pitta; F. Orso; S. Casara; M. Zampini et al. 

Breast stem cells and hormonal mechanisms in carcinogenesis

C. Brisken; O. Yalcin-Ozuysal; M. Beleut; R. D. Rajaram; M. Caikovski et al. 

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

C. Yang; L. Chen; C. Li; M. C. Lynch; C. Brisken et al. 

Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis

B. Hu; K. Lefort; W. Qiu; B-C. Nguyen; R. D. Rajaram et al. 

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multi-Lineage Differentiation Potential Similar to Mesenchymal Stem Cells

V. L. Battula; K. W. Evans; B. G. Hollier; Y. Shi; F. C. Marini et al. 

Hormone Action in the Mammary Gland

C. Brisken; B. O’Malley 

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Ö. Yalcin-Ozuysal; M. Fiche; M. Guitierrez; K-U. Wagner; W. Raffoul et al. 

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

B. W. Booth; C. A. Boulanger; L. H. Anderson; L. Jimenez-Rojo; C. Brisken et al. 

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

M. Beleut; R. RD; M. Caikovski; A. Ayyanan; D. Germano et al. 

Role of canonical Wnt signaling in mammary gland development

Rapid chromium quantification in solid oxide fuel cell cathodes

J. A. Schuler; P. Tanasini; A. Hessler; J. Van herle 

Stem cells in chemical carcinogenesis

C. Dietrich; C. Weiss; E. Bockamp; C. Brisken; T. Roskams et al. 

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells

A. Cicalese; G. Bonizzi; C. Pasi; M. Faretta; S. Ronzoni et al. 

From normal cell types to malignant phenotypes

O. Yalcin-Ozuysal; C. Brisken 

Epidermal Receptor Activator of NF-{kappa}B Ligand Controls Langerhans Cells Numbers and Proliferation

J. Barbaroux; M. Beleut; C. Brisken; C. Mueller; R. Groves 

The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer

A. Boulay; M. Breuleux; C. Stephan; C. Fux; C. Brisken et al. 

Endocrine Disruptors and Breast Cancer

C. Brisken 

What signals operate in the mammary niche?

T. Tanos; C. Brisken 

The epithelial-mesenchymal transition generates cells with properties of stem cells

S. A. Mani; W. Guo; M. J. Liao; E. N. Eaton; A. Ayyanan et al. 

New Frontiers in Asymmetric Catalysis edited by Koichi Mikami and Mark Lautens

J. Zhu 

Extended focus Fourier domain optical coherence microscopy assists developmental biology

M. L. Villiger; M. Beleut; C. Brisken; T. Lasser; R. A. Leitgeb 

An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells

S. Duss; S. Andre; A. L. Nicoulaz; M. Fiche; H. Bonnefoi et al. 

Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development

L. Ciarloni; S. Mallepell; C. Brisken 

Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective

C. Brisken; S. Duss 

Alveolar and Lactogenic Differentiation

C. Brisken; R. D. Rajaram 

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

A. Ayyanan; G. Civenni; L. Ciarloni; C. Morel; N. Mueller et al. 

Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland

S. Mallepell; A. Krust; P. Chambon; C. Brisken 

Identification of molecular apocrine breast tumours by microarray analysis

P. Farmer; H. Bonnefoi; V. Becette; M. Tubiana-Hulin; P. Fumoleau et al. 

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

V. Devgan; C. Mammucari; S. E. Millar; C. Brisken; G. P. Dotto 

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

E. Y. Chu; J. Hens; T. Andl; A. Kairo; T. P. Yamaguchi et al.