To develop translational biosensors that function in real-world applications, it is critical to have a foundational understanding of how the sensor works. Our team specializes in characterizing aptamer structure-switching dynamics using a diverse range of methodologies. By integrating experimental and theoretical approaches, we gain valuable insights into the unique structure-switching behavior of individual aptamer sequences, which guides our sensor design process and mechanistic understanding.
Monitoring serotonin aptamer binding via quartz crystal microbalance (left) and molecular dynamics simulations + FRET (right)
