Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

K. Pinjusic; G. Ambrosini; J. Lourenco; N. Fournier; C. Iseli et al. 

Engineering a synthetic signaling network in dendritic cells to improve anti-tumoral immunity

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

The role of LRRK2 in lung adenocarcinoma

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

B. Rothe; Y. Ikawa; Z. Zhang; T. A. Katoh; E. Kajikawa et al. 

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

B. Rothe; S. Fortier; C. Gagnieux; C. Schmuziger; D. B. Constam 

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

Metabolic dependencies of metastasis-initiating cells in breast cancer

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

K. Pinjusic; O. A. Dubey; O. Egorova; S. Nassiri; E. Meylan et al. 

Role of the androgen receptor in the human breast epithelium

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

The role of nicotinamide riboside metabolism in pancreatic beta cells

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

S. M. Leitao; B. Drake; K. Pinjusic; X. Pierrat; V. Navikas et al. 

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

K. Minegishi; B. Rothe; K. R. Komatsu; H. Ono; Y. Ikawa et al. 

Intestinal stem cells differentiation and its application in cancer therapy

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

B. Rothe; C. Gagnieux; L. C. Leal-Esteban; D. B. Constam 

Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

K. Loew; K. Hardes; C. Fedeli; N. G. Seidah; D. B. Constam et al. 

Role of Activin-A signaling in melanoma

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

Comment on “Human dignity and gene editing”

D. B. Constam 

Adamts18 Function in Mammary Gland Development

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

L. Leal-Esteban; B. Rothe; S. Fortier; M. Isenschmid; D. Constam 

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

B. Rothe; C. Leettola; L. Leal-Esteban; D. Cascio; S. Fortier et al. 

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

P. Ginefra; B. Filippi; P. Donovan; S. Bessonnard; D. Constam 

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

P. Donovan; O. A. Dubey; S. Kallioinen; K. W. Rogers; K. Muehlethaler et al. 

Targeting cancer stem cells by T cell engineering

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

Genomic targets and molecular partners of the chromatin regulator KAP1

Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification

S. Minocha; S. Bessonnard; T-L. Sung; C. Moret; D. B. Constam et al. 

Capturing epidermal stemness

AMP-activated protein kinase

Development of microfluidic devices for chemotaxis of primary stem cells

A balancing act between stratification and EMT in cultured human thymic epithelial cells

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

B. Rothe; L. Leal-Esteban; F. Bernet; S. Urfer; N. Doerr et al. 

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

P. S. Ellis; S. Burbridge; S. Soubes; K. Ohyama; N. Ben-Haim et al. 

GLUT1 and GLUT3 in non-small cell lung cancer

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

N. Piazzon; F. Bernet; L. Guihard; W. N. Leonhard; S. Urfer et al. 

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

S. Bessonnard; D. Mesnard; D. B. Constam 

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Regulation of the mRNA silencing activity of Bicaudal-C

Mechanisms underlying cell-fate determination in the mammary gland development

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

L. A. Lemaire; J. Goulley; Y. H. Kim; S. Carat; P. Jacquemin et al. 

Regulation of TGF beta and related signals by precursor processing

D. B. Constam 

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Spatio-temporal synchronization of biological oscillators

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

C. Fuerer; M. C. Nostro; D. B. Constam 

The useful gate-crasher

Identification of tumor-stroma interactions crucial for the establishment of liver metastasis

NMDAR signaling in cancer

Pathogen-free husbandry conditions alleviate behavioral deficits and neurodegeneration in AD10 anti-NGF mice

S. Tzanoulinou; R. Brandi; I. Arisi; M. D’Onofrio; S. M. Urfer et al. 

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

R. Essalmani; D. Susan-Resiga; A. Chamberland; M-C. Asselin; M. Canuel et al. 

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

W. C. Wetsel; R. M. Rodriguiz; J. Guillemot; E. Rousselet; R. Essalmani et al. 

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells Is Revealed by the ShcD/RaLP Adaptor Protein

M. Y. Turco; L. Furia; A. Dietze; L. F. Diaz; S. Ronzoni et al. 

Automated design of ligands to polypharmacological profiles

J. Besnard; G. F. Ruda; V. Setola; K. Abecassis; R. M. Rodriguiz et al. 

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing

N. Piazzon; C. Maisonneuve; I. Guilleret; S. Rotman; D. B. Constam 

Activin Signalling in Human Melanoma Cells

Visualization of proprotein convertase activity in living cells and tissues

D. Mesnard; D. Constam 

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

M. R-C. Kraus; S. Clauin; Y. Pfister; M. Di Maïo; T. Ulinski et al. 

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities

D. Mesnard; M. Donnison; C. Fuerer; P. L. Pfeffer; D. B. Constam 

The Role of Nodal Processing in Pluripotent Progenitors

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10

D. Susan-Resiga; R. Essalmani; J. Hamelin; M-C. Asselin; S. Benjannet et al. 

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst

D. Mesnard; D. B. Constam 

Role of Bicaudal-C in Left-Right Axis Formation and Kidney Morphogenesis

KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al. 

Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking

D. B. Constam 

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

D. B. Constam 

Intracellular trafficking and signaling in development

D. B. Constam 

Endoderm specification

A. Grapin-Botton 

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

C. Maisonneuve; I. Guilleret; P. Vick; T. Weber; P. Andre et al. 

Role of paracrine Furin activity during gastrulation

D. Mesnard; M. Donnison; P. L. Pfeffer; D. B. Constam 

Cripto localizes nodal at the limiting membrane of early endosomes

M. Blanchet; J. Le Good; V. Oorschot; S. Baflast; G. Minchiotti et al. 

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

M. Blanchet; J. Le Good; D. Mesnard; V. Oorschot; S. Baflast et al. 

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

D. Szumska; G. Pieles; R. Essalmani; M. Bilski; D. Mesnard et al. 

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction

D. D’Andrea; G. L. Liguori; J. A. Le Good; E. Lonardo; O. Andersson et al. 

Evolution of the mechanisms and molecular control of endoderm formation

A. Grapin-Botton; D. Constam 

The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4

N. Ben-Haim; C. Lu; M. Guzman-Ayala; L. Pescatore; D. Mesnard et al. 

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

D. Mesnard; M. Guzman-Ayala; D. B. Constam 

Nodal stability determines signaling range

J. A. Le Good; K. Joubin; A. J. Giraldez; N. Ben-Haim; S. Beck et al. 

A gene network establishing polarity in the early mouse embryo

S-L. Ang; D. B. Constam 

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment

M. Guzman-Ayala; N. Ben-Haim; S. Beck; D. B. Constam 

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements

S. D. Vincent; D. P. Norris; J. A. Le Good; D. B. Constam; E. J. Robertson 

Endoderm development

A. Grapin-Botton; D. Constam 

Watch thy neighbor: Proprotein convertases activate TGFß-related signals across tissue boundaries

D. Constam 

Extraembryonic proteases regulate Nodal signalling during gastrulation

S. Beck; J. A. Le Good; M. Guzman; N. Ben Haim; K. Roy et al. 

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping

D. B. Constam; E. J. Robertson 

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

D. B. Constam; E. J. Robertson 

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases

D. B. Constam; E. J. Robertson 

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

A. J. Roebroek; L. Umans; I. G. Pauli; E. J. Robertson; F. van Leuven et al. 

Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons

A. R. Tobler; D. B. Constam; A. Schmitt-Gräff; U. Malipiero; R. Schlapbach et al.