RECENT PUBLICATIONS (2014-2023)
- Selected original research articles
- Selected reviews
- Selected commentaries
***Selected original research articles***
Ghasemi A, Martinez-Usatorre A, Li L, […], Migliorini D, Heikenwalder M, & De Palma M. Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. Nat Cancer. 2024 Feb;5(2)-240-261.
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Bernier-Latmani J, et al. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth. Nat Cardiovasc Res. 2022 May; 1(5): 476–490.
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Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D’Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021 Aug 17;36(7):109522.
Martinez-Usatorre, A.*, Kadioglu, E.*, Boivin, G., Cianciaruso, C., Guichard, A., Torchia, B., Zangger, N., Nassiri, S., Keklikoglou, I., Schmittnaegel., M., Ries, C.H., Meylan, E., & De Palma, M. Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models. Sci Transl Med. 2021 Aug 11;13(606):eabd1616.
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Bissinger S, Hage C, Wagner V, Maser IP, Brand V, Schmittnaegel M, Jegg AM, Cannarile M, Watson C, Klaman I, Rieder N, González Loyola A, Petrova TV, Cassier PA, Gomez-Roca C, Sibaud V, De Palma, M, Hoves S, & Ries CH. Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition. Sci Transl Med. 2021 Jun 16;13(598):eabd4550.
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Jahani, Y, Arvelo ER, Yesilkoy F, Koshelev K, Cianciaruso C, De Palma M, Kivshar Y, & Altug H. Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles. Nat Communs. 2021 May 31;12:3246.
Kashyap, A.S.*, Schmittnaegel, M.*, Rigamonti, N., Pais-Ferreira, D., Mueller, P., Buchi, M., Ooi, C.-H., Kreuzaler, M., Hirschmann, P., Guichard, A., Rieder, N., Bill, R., Herting, F., Kienast, Y., Dirnhofer, S., Klein, C., Hoves, S., Ries, C. H., Corse, E., & De Palma, M.*, Zippelius, A*. Optimized anti-angiogenic reprogramming of tumor microenvironment by VEGFA and angiopoietin-2 blockade potentiates CD40 immunotherapy. Proc. Natl. Acad. Sci. U.S.A. 2020 .
Ragusa, S., Prat-Luri, B., González-Loyola, A., Nassiri, S., Squadrito, M.L., Guichard, A., Cavin, S., Gjorevski, N., Barras, D., Marra, G., Lutolf, M.P., Perentes, J., Corse, E., Bianchi, R., Wetterwald, L., Kim, J., Oliver, G., Delorenzi, M., De Palma, M., & Petrova, T.V. Anti-angiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice. J Clin Invest., 2020 Mar 2;130(3):1199-1216.
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Commentary (Claesson-Welsh): J Clin Invest. 2020 Mar 2;130(3):1093-1095.
Cianciaruso, C.*, Beltraminelli, T.*, Duval, F.*, Nassiri, S., Hamelin, R., Mozes, A., Gallart-Ayala, H., Ceada Torres, G., Torchia, B., Ries, C.H., Ivanisevic, J., & De Palma, M. Molecular profiling and functional analysis of macrophage-derived tumor extracellular vesicles. Cell Rep. 2019 June 4;27(10):3062-3080.e11.
Keklikoglou, I.*, Cianciaruso, C.*, Güç, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., & De Palma, M. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol. 2019 Feb;21(2):190-202.
Highlight: Nat Rev Cancer 2019 (doi: 10.1038/s41568-019-0111-2).
Highlights: F1000Prime (https://f1000.com/prime/734718811).
Neubert, N. J.*, Schmittnaegel, M.*, Bordry, N.*, Nassiri, S., Wald, N., Martignier, C., Tillé, L., Hemicsko, K., Damsky, W., Maby El-Hajjami, H., Klaman, I., Danenberg, E., Ioannidou, K., Kandalaft, L., Coukos, G., Hoves, S., Ries, C. H., Fuertes Marraco, S. A., Foukas, P. G., & De Palma, M.*, Speiser, D.E.* T cell-induced CSF1 promotes melanoma resistance to PD1 blockade. Sci Transl Med. 2018 Apr 11;10(436), pii: eaan3311.
Highlight: Cancer Immunol Res. 2018 June 1;6(6):629.
Keklikoglou, I., Kadioglu, E., Bissinger, S., Langlois, B., Bellotti, A., Orend, G., Ries, C.H. & De Palma, M. Periostin limits tumor response to VEGFA inhibition. Cell Rep. 2018 Mar;22(10):2530-2540.
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Squadrito, M.L., Cianciaruso, C., Hansen, S.K., & De Palma, M. EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens. Nat Methods. 2018 Mar;15(3):183-186.
Cortesi, F., Delfanti G., Grilli, A., Calcinotto A., Gorini, F., Pucci, F., Lucianò R., Grioni, M., Recchia, A., Benigni, F., Briganti, A., Salonia A., De Palma, M., Bicciato, S., Doglioni, C., Bellone, M., Casorati, G., Dellabona, P. Bimodal CD40/Fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression. Cell Rep. 2018 Mar;22(11):3006-3020.
Hoves, S., Ooi, C.-H., Wolter, C., Sade, H., Bissinger, S., Schmittnaegel, M., Ast, O., Giusti, A.M., Wartha, K., Runza, V., Xu, W., Kienast, Y., Cannarile, M.A., Levitsky, H., Romagnoli, S., De Palma, M., Rüttinger, D., & Ries, C.H. Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity. J Exp Med. 2018 March 5;215(3):859-876
Highlight: Cancer Immunol Res. 2018 May 1;6(5):501.
Scodeller, P., Simon Gracia, L., Kopanchuk, S., Tobi, A., Kilk, K., Säälik, P., Kurm, K., Squadrito, M.L., Kotamraju, V.R., Rinken, A., De Palma, M., Ruoslahti, E., & Teesalu, T. Precision targeting of tumor macrophages with a CD206 binding peptide. Sci Rep 2017Nov 7;7(1):14655.
Harney, S.A., Karagiannis, G.S., Pignatelli, J., Smith, B.D., Kadioglu, E., Wise, S.C., Hood, M.M., Kaufman, M.D., Leary, C.B., Lu, W.-P., Al-Ani, G., Chen, X., Entenberg, D., Oktay, M.H., Wang, Y., Chun, L., De Palma, M., Jones, J.G., Flynn, D.L., & Condeelis, J.S. The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors. Mol Cancer Ther. 2017 Nov 1;16(11):2486-2501.
Schmittnaegel, M.*, Rigamonti, N.*, Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., and De Palma, M. Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci Transl Med. 2017 Apr 12;9(385). pii: eaak9670.
Highlight: Nat Rev Clin Oncol. 2017 (doi: 10.1038/nrclinonc.2017.6).
Highlight: Nat Rev Drug Discov. 2017 (doi: 10.1038/nrd.2017.103).
Highlight: Nat Rev Rev Cancer 2017 (doi: 10.1038/nrc.2017.39).
Highlight: Science Signal. 2017 (doi: 10.1126/scisignal.aan4458).
Highlight: F1000Prime (https://f1000.com/prime/727504006).
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Cianciaruso, C., Phelps, E.A., Pasquier, M., Hamelin, R., Demurtas, D., Alibashe Ahmed, M., Piemonti, L., Hirosue, S., Swartz, M., De Palma, M., Hubbell, J.A., and Baekkeskov, S. Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity. Diabetes. 2017 Feb;66(2):460-473.
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He, H., Mack, J., Guc, E., Warren, C., Squadrito, M.L., Kilarski, W., Baer, C., Freshman, R., McDonald, A., Ziyad, S., Swartz, M.A., De Palma, M., and Iruela-Arispe, M.L. Perivascular Macrophages Limit Permeability. Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2203-2212
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Baer, C., Squadrito, M.L., Laoui, D., Thompson, D., Hansen, S.K., Kiialainen, A., Hoves, S., Ries, C.H., Ooi, C.-H., De Palma, M. Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumor immunity. Nat Cell Biol. 2016 Jul;18(7):790-802.
News & Views (Lee & Biswas): Nat Cell Biol. 2016 Jul;18(7):718-720.
Wallerius, M., Wallmann, T., Bartish, M., Östling, J., Mezheyeuski, A., Tobin, N.P., Nygren, E., Pangigadde, P.N., Pellegrini, P., Squadrito, M.L., Pontén, F., Hartman, J., Bergh, J., De Milito, A., De Palma, M., Ostman, A., Andersson, J., Rolny, C. Guidance molecule SEMA3A restricts tumor growth by differentially regulating the proliferation of tumor-associated macrophages. Cancer Res. 2016 Jun 1;76(11):3166-78 IF: 9.329
Galletti, G., Scielzo, C., Barbaglio, F., Veliz Rodriguez, T., Riba, M., Lazarevic, D., Cittaro, D., Simonetti, G., Ranghetti, P., Scarfò, L., Ponzoni, M., Rocchi, M., Corti, A., Anselmo, A., van Rooijen, N., Klein, C., Ries, H.C., Ghia, P., De Palma, M., Caligaris-Cappio, F., Bertilaccio, M.T.S. Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progression. Cell Rep. 2016 Feb 23;14(7):1748-60
Ferri, F., Parcelier, A., Petit, V., Gallouet, A.S., Lewandowski, D., Dalloz, M., van den Heuvel, A., Kolovos P., Sole, E., Squadrito, M.L., De Palma, M., Davidson, I., Rousselet, G., & Romeo, P.H. TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation. Nat Commun. 2015 Nov 23;6:8900.
Hughes, R., Qian, B.-Z., Muthana, M., Keklikoglou, I., Olson, O.C., Tazzyman, S., Danson, S.J., Addison, C.L., Clemons, M., Gonzalez-Angulo, A.M., Joyce, J.A., De Palma, M., Pollard, J.W., & Lewis, C.E. Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. Cancer Res. 2015 Sep 1;75(17):3479-91.
Keskin, D., Kim, J., Cooke, V.G., Wu, C.C., Sugimoto, H., Gu, C., De Palma, M., Kalluri, R., & LeBleu, V.S. Targeting vascular pericytes in hypoxic tumors promotes lung metastasis via angiopoietin-2. Cell Rep. 2015 Feb 24;10(7):1066-81.
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Squadrito, M.L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G.D., Lyle, R., Ibberson, M., & De Palma, M. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 2014 Sep 11;8(5):1432-1446.
Rigamonti, N., Kadioglu, E., Keklikoglou, I., Wyser Rmili, C., Leow, C.C., & De Palma, M. Role of angiopoietin-2 in adaptive tumor resistance to VEGF signalling blockade. Cell Rep. 2014 Aug 7;8(3):696-706.
Escobar, G., Moi, D., Ranghetti, A., Ozkal-Baydin, P., Squadrito, M.L., Kajaste-Rudnitski, A., Bondanza, A., Gentner, B., De Palma, M., Mazzieri, R., & Naldini, L. Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression. Sci Transl Med. 2014 Jan 1;6(217):217ra3
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***Selected reviews***
De Palma M & Hanahan D. Milestones in tumor vascularization and its therapeutic targeting. Nat Cancer. 2024 June 5(6):827-843.
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Beltraminelli, T., Perez, C.R. & De Palma, M. Disentangling the complexity of tumor-derived extracellular vesicles. Cell Rep. 2021 Apr 6;35(1):108960.
Beltraminelli, T. & De Palma, M. Biology and therapeutic targeting of tumor-associated macrophages. J Pathol. 2020 Apr;250(5):573-592.
Perez, C.R. & De Palma, M. Engineering dendritic cell vaccines to improve cancer immunotherapy. Nat Communs. 2019 Nov 27;10(1):5408.
Lapenna, A., De Palma, M. & Lewis, C.E. Perivascular macrophages in health and disease. Nat Rev Immunol. 2018 Nov;18(11):689-702.
Nowak-Sliwinska, P. et al. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis 2018 Aug;21(3):425-532.
Schmittnaegel, M. & De Palma, M. Reprogramming tumor blood vessels for enhancing immunotherapy. Trends Cancer 2017 Dec;3(12):809-812.
De Palma, M., Biziato, D., & Petrova, T.V. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017 Aug;17(8):457-474.
***Selected commentaries***
Mohammadzadeh Y & De Palma M. Boosting dendritic cell nanovaccines. Nat Nanotechnol. 2022 Apr 11.
Martinez-Usatorre A & De Palma M. Alzheimer’s drug turns macrophages against cancer. Nat Cancer. 2021 Nov;2(11):1119-1121.
Ghasemi, A. & De Palma, M. Tweaking the DNA of myeloid cells curbs cancer spread. Nature. 2020 Mar;579(7798):196-197.
Duval, F. & De Palma, M. Lymphoma chemotherapy: Hungry macrophages strike the final blow. Cancer Discov. 2019 Jul;9(7):834-836.
De Palma, M., Nassiri, S., Cianciaruso, C. Macrophage interference on chemotherapy. Nat Cell Biol. 2019 Apr;21(4):411-412.
De Palma, M. & Jain, R.K. CD4+ T cell activation and vascular normalization: Two sides of the same coin? Immunity. 2017 May 16;46(5):773-775.
De Palma, M. Origins of brain tumor macrophages. Cancer Cell. 2016 Dec 12;30(6):832-833.
Kadioglu, E. & De Palma, M. Cancer metastasis: Perivascular macrophages under watch. Cancer Discov. 2015 Sep;5(9):906-8.
Squadrito, M.L. & De Palma, M. A niche role for periostin and macrophages in glioblastoma. Nat Cell Biol 2015 Jan 30;17(2):107-9.
Biziato, D. & De Palma, M. Assessing metastasis risk after pre-operative anti-angiogenic therapy. EMBO Mol Med. 2014 Dec12;6(12):1515-7.
Keklikoglou, I. & De Palma, M. Cancer: Metastasis risk after anti-macrophage therapy. Nature. 2014 Nov 6;515(7525):46-7.
EPFL PATENTS
Title: Engineered antigen-presenting cells and uses thereof.
Inventors: Michele DE PALMA, Mario Leonardo SQUADRITO
Applicant: EPFL
Publication number: WO2017134100 A1; Application number: PCT/EP2017/052145
Priority date: Feb 2, 2016