Some animals, such as axolotls and zebrafish, possess remarkable abilities to regenerate their brains after injury, while mammals, including humans, are largely unable to repair damaged neurons. Understanding why regeneration is limited in some species but robust in others could unlock new strategies for brain repair. To address this, our lab focuses on two complementary research directions.
We investigate the molecular and cellular mechanisms underlying brain injury and regeneration across species. By integrating single-cell and spatial transcriptomics, lineage tracing, and gene regulatory network analysis, we aim to identify key factors that drive regeneration and explore evolutionary differences between proficient and deficient regenerators.
We develop advanced in vitro models, including 2D cultures and organoids, to dissect neural stem cell behavior and differentiation. Through screens and molecular profiling, we identify key drivers of regeneration. We develop advanced in vitro models, including 2D cultures and organoids, to dissect neural stem cell behavior and differentiation. Through screens and molecular profiling, we identify key drivers of regeneration. These findings inform in vivo strategies to enhance cell survival and integration post-injury.