In order to create better indoor spaces, it is necessary to understand how buildings impact indoor air quality and human comfort. Different aspects of building design, for example, energy saving measures, type of ventilation, material selection, occupancy profiles and building certification level, have been associated with altered exposures and comfort of building occupants to indoor pollutants. This research theme is centered on nationwide physical measurements of myriad indoor air pollutants and factors affecting thermal environments in diverse building types and with different assessment methods. This research domain is also accompanied with the large scale occupancy survey questionnaires. Together, this research vignette is intended to support diverse inquiries about indoor air quality and comfort in field settings.