It is anticipated that growth of smart building technology will redefine the way we work and live in the future. Despite the progress in the development of building ventilation and indoor environment standards, many studies indicate that percentage of satisfied people is significantly lower than that prescribed by the standards. With the development of IoT environmental sensing strategies, an opportunity space has been opened up for better control of building ventilation. This research theme aims to generate new insights about optimal sensor deployment and suitable ventilation design and operation in order to achieve an efficient, comfortable and healthy indoor spaces.