Publications

Metabolic dependencies of metastasis-initiating cells in female breast cancer

C. M. Young; L. N. K. Beziaud; P. V. Dessen; A. M. Alonso; A. Santamaria-Martinez et al. 

Nature Communications. 2023-11-04. Vol. 14, num. 1, p. 7076. DOI : 10.1038/s41467-023-42748-8.

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Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

G. M. Ramzy; M. Norkin; T. Koessler; L. Voirol; M. Tihy et al. 

Journal Of Experimental & Clinical Cancer Research. 2023-04-03. Vol. 42, num. 1, p. 79. DOI : 10.1186/s13046-023-02650-z.

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Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

I. M. Roy; P. V. Anu; S. Zaunz; S. Reddi; A. M. Giri et al. 

Iscience. 2022-10-21. Vol. 25, num. 10, p. 105171. DOI : 10.1016/j.isci.2022.105171.

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High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

M. Norkin; P. Ordóñez-Morán; J. Huelsken 

Cell Reports. 2021-04-20. Vol. 35, num. 3, p. 109026. DOI : 10.1016/j.celrep.2021.109026.

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Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

V. S. Dionellis; M. Norkin; A. Karamichali; G. G. Rossetti; J. Huelsken et al. 

Cancers. 2021-04-12. Vol. 13, num. 6, p. 1267. DOI : 10.3390/cancers13061267.

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Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

S. H. Mehatre; I. M. Roy; A. Biswas; D. Prit; S. Schouteden et al. 

Journal Of Immunology. 2021-04-01. Vol. 206, num. 7, p. 1549-1560. DOI : 10.4049/jimmunol.2001066.

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The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

A. Biswas; I. M. Roy; P. C. Babu; J. Manesia; S. Schouteden et al. 

Stem Cell Reports. 2020-08-11. Vol. 15, num. 2, p. 340-357. DOI : 10.1016/j.stemcr.2020.06.022.

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γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

N. Luong-Gardiol; I. Siddiqui; I. Pizzitola; B. Jeevan-Raj; M. Charmoy et al. 

Cancer Cell. 2019-04-15. Vol. 35, num. 4, p. 649-663.e10. DOI : 10.1016/j.ccell.2019.03.005.

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A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance

J. Huelsken; D. Hanahan 

CELL. 2018. Vol. 172, num. 4, p. 643-644. DOI : 10.1016/j.cell.2018.01.028.

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Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

T. M. Malta; A. Sokolov; A. J. Gentles; T. Burzykowski; L. Poisson et al. 

Cell. 2018-04-05. Vol. 173, num. 2, p. 338-354.e15. DOI : 10.1016/j.cell.2018.03.034.

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Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature

P. C. Schwalie; P. Ordonez-Moran; J. Huelsken; B. Deplancke 

Stem Cells. 2017. Vol. 35, num. 12, p. 2390-2402. DOI : 10.1002/stem.2719.

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Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

N. Lugli; V. S. Dionellis; P. Ordonez-Moran; I. Kamileri; S. K. Sotiriou et al. 

Cell Reports. 2017. Vol. 19, num. 11, p. 2185-2192. DOI : 10.1016/j.celrep.2017.05.051.

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Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

J-P. Abbuehl; Z. Tatarova; W. Held; J. Huelsken 

Cell Stem Cell. 2017. Vol. 21, num. 2, p. 241-+. DOI : 10.1016/j.stem.2017.07.004.

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Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

S. Khurana; S. Schouteden; J. K. Manesia; A. Santamaria-Martinez; J. Huelsken et al. 

Nature Communications. 2016-12-01. Vol. 7, p. 13500. DOI : 10.1038/ncomms13500.

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Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Z. Tatarova; J. P. Abbuehl; S. Maerkl; J. Huelsken 

Lab On A Chip. 2016. Vol. 16, num. 10, p. 1934-1945. DOI : 10.1039/c6lc00236f.

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Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

F. Chiacchiera; A. Rossi; S. Jammula; A. Piunti; A. Scelfo et al. 

Cell Stem Cell. 2016. Vol. 18, num. 1, p. 91-103. DOI : 10.1016/j.stem.2015.09.019.

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Phage selection of chemically stabilized alpha-helical peptide ligands

P. Diderich; D. Bertoldo; P. Dessen; M. M. Khan; I. Pizzitola et al. 

ACS Chemical Biology. 2016. Vol. 11, num. 5, p. 1422-1427. DOI : 10.1021/acschembio.5b00963.

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Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

D. Bertoldo; M. M. G. Khan; P. Dessen; W. Held; J. Huelsken et al. 

ChemMedChem. 2016. Vol. 11, num. 8, p. 834-839. DOI : 10.1002/cmdc.201500557.

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HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

P. Ordonez-Moran; C. Dafflon; M. Imajo; E. Nishida; J. Huelsken 

Cancer Cell. 2015. Vol. 28, num. 6, p. 815-829. DOI : 10.1016/j.ccell.2015.11.001.

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Complex metastatic niches: already a target for therapy?

P. Ordóñez-Morán; J. Huelsken 

Current Opinion in Cell Biology. 2014. Vol. 31, p. 29-38. DOI : 10.1016/j.ceb.2014.06.012.

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SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

P. Ordóñez-Morán; A. Irmisch; A. Barbáchano; I. Chicote; S. Tenbaum et al. 

Oncogene. 2014. Vol. 33, num. 15, p. 1975-1985. DOI : 10.1038/onc.2013.140.

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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

K. J. Petherick; A. C. Williams; J. D. Lane; P. Ordóñez-Morán; J. Huelsken et al. 

The EMBO Journal. 2013. Vol. 32, num. 13, p. 1903-1916. DOI : 10.1038/emboj.2013.123.

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Metastasis: New insights into organ-specific extravasation and metastatic niches

A. Irmisch; J. Huelsken 

Experimental Cell Research. 2013. Vol. 319, num. 11, p. 1604-1610. DOI : 10.1016/j.yexcr.2013.02.012.

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The niche under siege: novel targets for metastasis therapy

A. S. Martínez; J. Huelsken 

Journal of internal medicine. 2013. Vol. 274, num. 2, p. 127-136. DOI : 10.1111/joim.12024.

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β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; M. Al-Kharusi; T. J. Collard et al. 

British Journal of Cancer. 2012. Vol. 107, num. 9, p. 1514-1517. DOI : 10.1038/bjc.2012.430.

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Lrig1: a new master regulator of epithelial stem cells

P. Ordóñez-Morán; J. Huelsken 

The EMBO Journal. 2012. Vol. 31, num. 2, p. 2064-2066. DOI : 10.1038/emboj.2012.73.

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Interactions between cancer stem cells and their niche govern metastatic colonization

I. Malanchi; A. Santamaria-Martínez; E. Susanto; H. Peng; H-A. Lehr et al. 

Nature. 2012. Vol. 481, num. 7379, p. 85-89. DOI : 10.1038/nature10694.

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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

H. J. M. Smartt; A. Greenhough; P. Ordóñez-Morán; E. Talero; C. A. Cherry et al. 

Gut. 2011. Vol. 61, num. 9, p. 1306-14. DOI : 10.1136/gutjnl-2011-300817.

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Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

T. Holowacz; J. Huelsken; D. Dufort; D. Van Der Kooy 

European Journal of Neuroscience. 2011. Vol. 33, p. 1366-75. DOI : 10.1111/j.1460-9568.2011.07632.x.

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Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

G. Jeannet; C. Boudousquié; N. Gardiol; J. Kang; J. Huelsken et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2010. Vol. 107, num. 21, p. 9777-82. DOI : 10.1073/pnas.0914127107.

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SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

T. Hussenet; S. Dali; J. Exinger; B. Monga; B. Jost et al. 

PLoS One. 2010. Vol. 5, num. 1, p. e8960. DOI : 10.1371/journal.pone.0008960.

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

M. Buchert; D. Athineos; H. E. Abud; Z. D. Burke; M. C. Faux et al. 

PLoS genetics. 2010. Vol. 6, num. 1, p. e1000816. DOI : 10.1371/journal.pgen.1000816.

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Canonical Wnt signalling plays essential roles

J. Huelsken; W. Held 

European Journal of Immunology. 2009. Vol. 39, num. 12, p. 3582-3583. DOI : 10.1002/eji.200838982.

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Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction

Y. Zhang; P. Tomann; T. Andl; N. Gallant; J. Huelsken et al. 

Developmental Cell. 2009. Vol. 17, num. 1, p. 49-61. DOI : 10.1016/j.devcel.2009.05.011.

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Tissue-specific stem cells: friend or foe?

J. Huelsken 

Cell Res. 2009. Vol. 19, num. 3, p. 279-81. DOI : 10.1038/cr.2009.24.

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Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1

A. Braeuning; R. Sanna; J. Huelsken; M. Schwarz 

Drug Metab Dispos. 2009. Vol. 37, num. 5, p. 1138-45. DOI : 10.1124/dmd.108.026179.

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Cancer stem cells: never Wnt away from the niche

I. Malanchi; J. Huelsken 

Current Opinion in Oncology. 2009. Vol. 21, num. 1, p. 41-6. DOI : 10.1097/CCO.0b013e32831d1faf.

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Differential requirement for beta-catenin in epithelial and fiber cells during lens development

S. Cain; G. Martinez; M. Kokkinos; K. Turner; R. Richardson et al. 

Developmental Biology. 2008. Vol. 321, num. 2, p. 420-433. DOI : 10.1016/j.ydbio.2008.07.002.

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Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

I. Malanchi; H. Peinado; D. Kassen; T. Hussenet; D. Metzger et al. 

Nature. 2008. Vol. 452, num. 7187, p. 650-653. DOI : 10.1038/nature06835.

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Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels

Y. Xu; R. Reboulet; B. Quinn; J. Huelsken; D. Witte et al. 

Molecular genetics and metabolism. 2008. Vol. 94, num. 2, p. 190-203. DOI : 10.1016/j.ymgme.2008.01.013.

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Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin

G. Jeannet; M. Scheller; L. Scarpellino; S. Duboux; N. Gardiol et al. 

Blood. 2008. Vol. 111, num. 1, p. 142-9. DOI : 10.1182/blood-2007-07-102558.

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Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

T. Fevr; S. Robine; D. Louvard; J. Huelsken 

Molecular and Cellular Biology. 2007. Vol. 27, num. 21, p. 7551-9. DOI : 10.1128/MCB.01034-07.

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Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

U. Schaeper; R. Vogel; J. Chmielowiec; J. Huelsken; M. Rosario et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2007. Vol. 104, num. 39, p. 15376-81. DOI : 10.1073/pnas.0702555104.

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beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells

M. M. Faraldo; J. Teuliere; M. A. Deugnier; W. Birchmeier; J. Huelsken et al. 

FEBS Letters. 2007. Vol. 581, num. 5, p. 831-6. DOI : 10.1016/j.febslet.2007.01.053.

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Beta-catenin downregulation is required for adaptive cardiac remodeling

A. Baurand; L. Zelarayan; R. Betney; C. Gehrke; S. Dunger et al. 

Circulation Research. 2007. Vol. 100, num. 9, p. 1353-62. DOI : 10.1161/01.RES.0000266605.63681.5a.

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Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation

M. Scheller; J. Huelsken; F. Rosenbauer; M. M. Taketo; W. Birchmeier et al. 

Nature Immunology. 2006. Vol. 7, num. 10, p. 1037-47. DOI : 10.1038/ni1387.

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Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival

D. Goux; J. D. Coudert; D. Maurice; L. Scarpellino; G. Jeannet et al. 

Blood. 2005. Vol. 106, num. 5, p. 1726-33. DOI : 10.1182/blood-2005-01-0337.

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Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks

F. Naef; J. Huelsken 

Nucleic Acids Res. 2005. Vol. 33, num. 13, p. e111. DOI : 10.1093/nar/gni104.

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Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

J. Dessimoz; C. Bonnard; J. Huelsken; A. Grapin-Botton 

Current Biology. 2005. Vol. 15, num. 18, p. 1677-1683. DOI : 10.1016/j.cub.2005.08.037.

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Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation

K. S. Grossmann; C. Grund; J. Huelsken; M. Behrend; B. Erdmann et al. 

Journal of Cell Biology. 2004. Vol. 167, num. 1, p. 149-60. DOI : 10.1083/jcb.200402096.

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beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation

J. Teuliere; M. M. Faraldo; M. Shtutman; W. Birchmeier; J. Huelsken et al. 

Molecular and Cellular Biology. 2004. Vol. 24, num. 19, p. 8649-61. DOI : 10.1128/MCB.24.19.8649-8661.2004.

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Role of beta-catenin in synaptic vesicle localization and presynaptic assembly

S. X. Bamji; K. Shimazu; N. Kimes; J. Huelsken; W. Birchmeier et al. 

Neuron. 2003. Vol. 40, num. 4, p. 719-31. DOI : 10.1016/S0896-6273(03)00718-9.

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Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

N. Soshnikova; D. Zechner; J. Huelsken; Y. Mishina; R. R. Behringer et al. 

Genes & Development. 2003. Vol. 17, num. 16, p. 1963-8. DOI : 10.1101/gad.263003.

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Deletion of beta-catenin impairs T cell development

Y. Xu; D. Banerjee; J. Huelsken; W. Birchmeier; J. M. Sen 

Nature Immunology. 2003. Vol. 4, num. 12, p. 1177-82. DOI : 10.1038/ni1008.

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beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

D. Zechner; Y. Fujita; J. Huelsken; T. Muller; I. Walther et al. 

Developmental Biology. 2003. Vol. 258, num. 2, p. 406-18. DOI : 10.1016/S0012-1606(03)00123-4.

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Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

M. Morkel; J. Huelsken; M. Wakamiya; J. Ding; M. van de Wetering et al. 

Development. 2003. Vol. 130, num. 25, p. 6283-94. DOI : 10.1242/dev.00859.

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beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis

M. L. Mucenski; S. E. Wert; J. M. Nation; D. E. Loudy; J. Huelsken et al. 

Journal of Biological Chemistry. 2003. Vol. 278, num. 41, p. 40231-8. DOI : 10.1074/jbc.M305892200.

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The Wnt signalling pathway

J. Huelsken; J. Behrens 

Journal of Cell Science. 2002. Vol. 115, num. Pt 21, p. 3977-8. DOI : 10.1242/jcs.00089.

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Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling

M. H. Wong; J. Huelsken; W. Birchmeier; J. I. Gordon 

Journal of Biological Chemistry. 2002. Vol. 277, num. 18, p. 15843-50. DOI : 10.1074/jbc.M200184200.

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Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

C. Niemann; D. M. Owens; J. Huelsken; W. Birchmeier; F. M. Watt 

Development. 2002. Vol. 129, num. 1, p. 95-109.

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The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

T. Schwarz-Romond; C. Asbrand; J. Bakkers; M. Kuhl; H. J. Schaeffer et al. 

Genes & Development. 2002. Vol. 16, num. 16, p. 2073-84. DOI : 10.1101/gad.230402.

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Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

R. Schmidt-Ullrich; T. Aebischer; J. Huelsken; W. Birchmeier; U. Klemm et al. 

Development. 2001. Vol. 128, num. 19, p. 3843-53.

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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

J. Huelsken; R. Vogel; B. Erdmann; G. Cotsarelis; W. Birchmeier 

Cell. 2001. Vol. 105, num. 4, p. 533-45. DOI : 10.1016/S0092-8674(01)00336-1.

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New aspects of Wnt signaling pathways in higher vertebrates

J. Huelsken; W. Birchmeier 

Current Opinion in Genetics & Development. 2001. Vol. 11, num. 5, p. 547-553. DOI : 10.1016/S0959-437X(00)00231-8.

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Requirement for beta-catenin in anterior-posterior axis formation in mice

J. Huelsken; R. Vogel; V. Brinkmann; B. Erdmann; C. Birchmeier et al. 

Journal of Cell Biology. 2000. Vol. 148, num. 3, p. 567-78. DOI : 10.1083/jcb.148.3.567.

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

M. Sachs; H. Brohmann; D. Zechner; T. Muller; J. Huelsken et al. 

Journal of Cell Biology. 2000. Vol. 150, num. 6, p. 1375-84. DOI : 10.1083/jcb.150.6.1375.

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Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines

C. Denk; J. Huelsken; E. Schwarz 

Cancer Lett. 1997. Vol. 120, num. 2, p. 185-93. DOI : 10.1016/S0304-3835(97)00308-X.

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Adherens junction proteins in tumour progression

W. Birchmeier; J. Huelsken; J. Behrens 

Cancer Surveys. 1995. Vol. 24, p. 129-140.

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E-cadherin as an invasion suppressor

W. Birchmeier; J. Huelsken; J. Behrens 

Ciba Found Symp. 1995. Vol. 189, p. 124-136.

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Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development

C. Kraus; T. Liehr; J. Huelsken; J. Behrens; W. Birchmeier et al. 

Genomics. 1994. Vol. 23, num. 1, p. 272-4. DOI : 10.1006/geno.1994.1493.

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

J. Huelsken; W. Birchmeier; J. Behrens 

Journal of Cell Biology. 1994. Vol. 127, num. 6 Pt 2, p. 2061-9. DOI : 10.1083/jcb.127.6.2061.

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Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

J. Huelsken; J. Behrens; W. Birchmeier 

Current Opinion in Cell Biology. 1994. Vol. 6, num. 5, p. 711-716. DOI : 10.1016/0955-0674(94)90098-1.

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Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas

W. Birchmeier; K. M. Weidner; J. Huelsken; J. Behrens 

Seminars in Cancer Biology. 1993. Vol. 4, num. 4, p. 231-239.

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