Investigation of the plasticity of deep brain structures in mild cognitive impairment and healthy aging
The cerebellum and striatum are now known to be important hubs for both sensorimotor and higher cognitive functions, like working memory, are less affected during aging and many neurodegenerative diseases, like Alzheimer’s disease.
Pursuing this concept, external priming of the cerebellar activity could further enhance the striatal activity supported by a recently validated temporal interferent electrical stimulation and differentially affect working memory. In this project, we apply non-invasive cerebellar stimulation followed by a working memory task with concomitant temporal interference transcranial electrical stimulation, targeting the striatum of 20 mild cognitive impairment patients, while they complete a computer-based task.