Treating apathy by non-invasive transcranial temporal interference stimulation (tTIS) of the striatum
Apathy is a transdiagnostic syndrome of impaired motivation which has a large impact on quality of life and is extremely prevalent in a variety of neuropsychiatric disorders including traumatic brain injury (61%), Alzheimer’s disease (49%), Parkinson’s disease (40%) and stroke (36%).
The apatTIS project aims at obtaining a comprehensive understanding of striatal neuromodulation effects on motivated behavior in healthy participants and patients suffering from apathy, testing the effectiveness of this approach toward clinical translation.