Underlying Network mechanisms to novel interventions of Brain Lesion Induced Fatigue
Fatigue is a common symptom in neurological disorders and is particularly frequent following acquired brain lesions such as stroke and traumatic brain injury. It significantly impairs physical and cognitive functioning, limiting patients suffering from it in their work and social life.
In this project, we are analysing an ample, multi-modal dataset of stroke patients to investigate the disrupted brain networks latent to fatigue using advanced structural (dis)connectomics.
We will examine the involvement of cortical and subcortical structures in fatigue and identify targets for a non-invasive brain stimulation (NIBS) paradigm. During this study, we will utilise transcranial temporal interference stimulation (tTIS) combined with an attention probing task, aiming to reduce fatigue in our patient cohorts.