Deep dive into huntingtin inclusions
Reconstructing Lewy body formation offers insight into pathology formation and neurodegeneration in Parkinson’s disease:
A new perspective on the role of phosphorylation in Alzheimer’s and other tau pathologies:
Nathan Riguet et al. “Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties” BioRxiv (2020) doi: https://doi.org/10.1073/pnas.1913904117
Reconstructing Lewy body formation offers insight into pathology formation and neurodegeneration in Parkinson’s disease:
Anne-Laure Mahul-Mellier et al. “The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.” PNAS (2020) doi: https://doi.org/10.1073/pnas.1913904117
A new perspective on the role of phosphorylation in Alzheimer’s and other tau pathologies:
Haj-Yahya et al. “Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding.” Angewandte Chemie (2019). doi: https://doi.org/10.1002/anie.201913001