Methods development

We could advance in our investigation thanks to the use and development of state-of-the-art molecular modelling and simulations at different levels of resolution and theory, which  allow us to explore dynamic features that are usually non accessible to experimental tech–niques. In a integrative modeling (IM) framework, where structural biology and biophysics intersect with theory and computational science, we strive to combine computationally de–rived information with available experimental data to better characterise membrane-protein, protein-protein and protein-nucleic acid interactions essential for the function of the macromolecular assemblies that sustain life.