LCBM

Our main focus is to understand the molecular organization and function of chromatin – the DNA-protein complex which organizes the eukaryotic genome and regulates gene expression, as well as the cytoskeleton, using a combination of chemistry and biophysics.

Positions:

There are open positions for PhD students and Postdocs!

We have been awarded a SNSF Advanced Grant, which will start in 2024! We are thus assembling a high-powered team of PhD students and postdocs for the challenging and exciting project “Site-specific Access of Regulatory Chromatin in Cells – siteSEARCH“. If you are interested to join, contact directly: beat.fierz@epfl.ch.

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PRODIGY

The LCBM is a member of the PRODIGY consortium – Protein-based molecular design for next generation Therapy. Check out details here:

https://www.nccr-prodigy.ch/

Recent publications @LCBM

New preprint!

How are pioneer TFs searching for target sites in eukaryotic chromatin?

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New preprint!

Single-molecule chromatin ubiquitylation by PRC1

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Structural basis of Sirt7 regulation

Combining chemical biology and cryoEM we reveal how SIRT7 discriminates H3K36 and H3K18 for deacylation.

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H1 ubiquitylation controls RNF168.

Chemically di-ubiquitylated H1 variants reveal position-dependent stimulation of the DNA repair protein RNF168

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Dynamics of centrochromatin.

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

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Tubulin engineering.

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

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