Welcome to the Laboratory of Asymmetric Catalysis and Synthesis (LCSA) headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.
LATEST NEWS
22.11.2023: Yi-Xuan’s new publication on asymmetric nickel catalysis is now available in Nature Communications. Check it out!
15.11.2023: Patrick joined the group as a new PhD student. Welcome to the LCSA Patrick!
15.09.2023: Marvin joined the group as a new PhD student. Welcome to the LCSA Marvin!
15.06.2023: Sebastian started as a new postdoctoral researcher. Welcome Sebastian!
29.03.2023: Check out SwissCat+: the future of catalyst discovery and optimization in Chimia.
29.03.2023: Recent work of the NCCR’s in silico catalyst optimization can be found in Chimia.
24.03.2023: Aragorn Laverny successfully defended his PhD thesis. Congrats Aragorn!
23.02.2023: Check out Guoting’s paper on the DAP-catalyzed asymmetric Aza-Mislow-Evans Rearrangement in Angewandte Chemie. Congrats!
22.02.2023: Yi-Xuan’s and Matthew’s impressive work on asymmetric nickel catalysis is now available on ChemRxiv. Congrats!
LATEST PUBLICATIONS
S. Jana, N. Cramer, J. Am. Chem. Soc. 2024, 146, 35199-35207: “Tunable Thiazolium Carbenes for Enantioselective Radical Three-Component Dicarbofunctionalizations“
Y. S. Ye, A. Laverny, M. D. Woodrich, R. Laplaza, F. Fadaei-Tirani, R. Scopelliti, C. Corminboeuf, N. Cramer, J. Am. Chem. Soc. 2024, 146, 34786-34795: “Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations“
Y.-X. Cao, A.-S. Chauvin, S. Tong, L. Alama, N. Cramer, ChemRxiv 2024, doi:10.26434/chemrxiv-2024-3w4p4: “Accessing Carbon, Boron and Germanium Spiro Stereocenters in a Unified Catalytic Enantioselective Approach“
A. Madron du Vigné, N. Cramer, Chem. Sci. 2024, 15, 13864-13871: “Streamlined synthetic assembly of α-chiral CAAC ligands and catalytic performance of their copper and ruthenium complexes“
Y. Zhang, J.-J. Zhang, L. Lou, R. Lin, N. Cramer, S.-G. Wang and Z. Chen, Chem. Soc. Rev. 2024, 53, 3457-3484: “Recent advances in Rh(I)-catalyzed enantioselective C–H functionalization“
G. Zhang, M. D. Wodrich, N. Cramer, Science 2024, 383, 395-401: “Catalytic enantioselective reductive Eschenmoser-Claisen rearrangements“
P. Laveille, P. Miéville, S. Chatterjee, E. Clerc, J.-C. Cousty, F. de Nanteuil, E. Lam, E. Mariano, A. Ramirez, U. Randrianarisoa, K. Villat, C. Copéret, N. Cramer, Chimia 2023, 77, 154-158: “Swiss Cat+, a Data-driven Infrastructure for Accelerated Catalysts Discovery and Optimization”
M. D. Wodrich, R. Laplaza, N. Cramer, M. Reiher, C. Corminboeuf, Chimia 2023, 77, 139-143: “Toward in silico Catalyst Optimization”
Y.-X. Cao, M. D. Wodrich, N. Cramer, Nat. Commun. 2023, 14, 7640: “Nickel-catalyzed direct stereoselective α-allylation of ketones with non-conjugated dienes“
G. Zhang, N. Cramer, Angew. Chem. Int. Ed. 2023, e202301076: “Reductive Asymmetric Aza-Mislow-Evans Rearrangement by 1,3,2-Diazaphospholene Catalysis”