Since 2020, our group is also part of NCCR Catalysis, a National Center of Competence in Research of the Swiss National Science Foundation, with the goal of developing more efficient and sustainable catalytic processes for the synthesis of fine chemicals. In phase I of the NCCR, we focused especially on catalytic tethered reactions, copper catalysis and photocatalysis. We also initiated our efforts in digital chemistry within the frame of NCCR Catalysis. With the beginning of phase II of the NCCR in 2024, our focus has moved more towards the use of heterogenous (photo)catalysts in organic chemistry, as well as an increased digitalization of the development of catalytic processes. You will find below a list of publications that have appeared within the framework of NCCR Catalysis.
Journal Articles
2025
Photocatalyzed Azidofunctionalization of Alkenes via Radical-Polar Crossover
Pierre Palamini, Alexandre A. Schoepfer and Jerome Waser
Angew. Chem., Int. Ed. 2025, 64, e202420455. (10.1002/anie.202420455) Green Access Raw data
2024
Cost-informed Bayesian reaction optimization
Alexandre A Schoepfer, Jan Weinreich, Ruben Laplaza, Jerome Waser and Clemence Corminboeuf
Digital Discovery 2024, 3, 2289-2297. (10.1039/D4DD00225C) Open Access! Joined publication with LCMD.
Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols
Helena Solé-Àvila, Mikus Puriņš, Lucas Eichenberger and Jerome Waser
Angew. Chem. Int. Ed. 2024, 63, e202411383. (10.1002/anie.202411383) Open Access! Raw data
Reaction-Agnostic Featurization of Bidentate Ligands for Bayesian Ridge Regression of Enantioselectivity
Alexandre A. Schoepfer, Ruben Laplaza, Matthew D. Wodrich, Jerome Waser, and Clemence Corminboeuf
ACS Catal. 2024, 14, 9302-9312. (10.1021/acscatal.4c02452) Open Access! Code, Visualizations, Joined publication with LCMD.
Organic Dye Photocatalyzed Synthesis of Functionalized Lactones and Lactams via a Cyclization–Alkynylation Cascade
Diana Cavalli and Jerome Waser
Org. Lett. 2024, 26, 4235–4239. (10.1021/acs.orglett.4c01078) Open Access! Raw data
SOMOphilic alkyne vs radical-polar crossover approaches: The full story of the azido-alkynylation of alkenes
Julien Borrel and Jerome Waser
Beilstein J. Org. Chem. 2024, 20, 701-713. (10.3762/bjoc.20.64) Open Access!
Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis
Angel Rentería-Gómez, Rubén O. Torres-Ochoa, Pierre Palamini, Raphaël Simonet-Davin, Qian Wang, Jérôme Waser, Jieping Zhu
Helv. Chim. Acta 2024, 107, e202400004. (10.1002/hlca.202400004) Open Access! Joined publication with LSPN.
2023
Acyl-Ethynylbenziodoxolone (acyl-EBX): Access to Ketene Dithioarylacetals
Pierre Palamini, Julien Borrel, Maël Djaïd, Morgane Delattre and Jerome Waser
Org. Lett. 2023, 25, 7535-7539. (10.1021/acs.orglett.3c02869) Green Access Raw data
Iron-Catalyzed Synthesis of α-Azido α-Amino Esters via the Alkylazidation of Alkenes
Pierre Palamini, Emmanuelle M. D. Allouche, and Jerome Waser
Org. Lett. 2023, 25, 6791-6795. (DOI: 10.1021/acs.orglett.3c02153) Open Access! Raw data
Azido-alkynylation of alkenes through radical-polar crossover
Julien Borrel and Jerome Waser
Chem. Sci. 2023, 14, 9452-9460. (DOI: 10.1039/D3SC03309K) Open Access! Raw data
Copper (I)-BOX Catalyzed Asymmetric 3-Component Reaction for the Synthesis of Trifluoromethylated Propargylic Ethers and Anilines
Nieves P. Ramirez and Jerome Waser
Angew. Chem., Int. Ed. 2023, 62, e202305776. (DOI: 10.1002/anie.202305776) Open Access! Raw data
Synthesis of propargyl silanes from terminal alkynes via a migratory Sonogashira reaction
Mikus Purins, Lucas Eichenberger, and Jerome Waser
Chem. Commun. 2023, 59, 7931-7934. (DOI: 10.1039/D3CC01847D ) Open Access! Raw data
X-Ray and NMR Structural Data of Ethynylbenziodoxolones (EBXs) Reagents and Their Analogues
Eliott Le Du, Nieves P. Ramirez, Stefano Nicolai, Rosario Scopelliti, Farzaneh Fadaei-Tirani, Matthew D. Wodrich, Durga Prasad Hari and Jerome Waser
Helv. Chim. Acta 2023, e202200175. (DOI: 10.1002/hlca.202200175 ) Open Access!
2022
Exploring Photoredox-Catalyzed (Re)functionalizations with Core-Modified Benziodoxolones
Stephanie G. E. Amos, Franck Le Vaillant and Jerome Waser
Helv. Chim. Acta 2022, e202200161. (10.1002/hlca.202200161) Green Access
Pd(II)-Catalyzed Aminoacetoxylation of Alkenes Via Tether Formation
Thomas Rossolini, Ashis Das, Stefano Nicolai and Jerome Waser
Org. Lett. 2022, 24, 5068-5072. (10.1021/acs.orglett.2c01838) Raw data Open Access!
Palladium-Catalyzed trans-Hydroalkoxylation: Counterintuitive Use of an Aryl Iodide Additive to Promote C–H Bond Formation
Ashis Das, Luca Buzzetti, Mikus Puriņš and Jerome Waser
ACS catal. 2022, 12, 7565-7570. (10.1021/acscatal.2c01809) Raw data Open Access!
Asymmetric Cyclopropanation and Epoxidation via a Catalytically Formed Chiral Auxiliary
Mikus Purins and Jerome Waser
Angew. Chem., Int. Ed. 2022, 61, e202113925. (10.1002/anie.202113925) Raw data Open Access!
2021
Direct Photoexcitation of EthynylBenziodoXolones: An Alternative to Photocatalysis for Alkynylation Reaction
Stephanie G. E. Amos, Diana Cavalli, Franck Le Vaillant and Jerome Waser
Angew. Chem., Int. Ed. 2021, 60, 23827-23834. (10.1002/anie.202110257) Raw data Open Access!
Cu(I)-Catalyzed gem-Aminoalkynylation of Diazo Compounds: Synthesis of Fluorinated Propargylic Amines
Nieves P. Ramirez, Guillaume Pisella and Jerome Waser
J. Org. Chem. 2021, 86 , 10928–10938. (10.1021/acs.joc.1c01423) Green Access Raw data
Review Articles
2024
Merging the Reactivity of (Pseudo)cyclic Hypervalent Iodine Reagents and Carbenes or Carbenoids
Nieves P. Ramirez* and Jerome Waser
Synthesis 2024, in press. (DOI: 10.1055/a-2418-8285 ).
