Synthesis Problems

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2024

1. (−)-Aleutianamine (Tokuyama, 2023)
2. Cephinoid P (Gao, 2023)
3. Retrosynthesis
4. Mechanisms by Jerome
5. Cyclocitinol & (-)-Longithorone A (Gui & Shair, 2022 & 2018)
6. (-)-Himalensine A (Dixon, 2017)
7. (+)-Caldaphnidine J (Xu, 2020)
8. Mechanisms by Jerome
9. Puberuline C (Inoue, 2023)
10. Illisimonin A (Kalesse, 2023)
11. Wickerol A and B (Gui, 2020)
12. Conidiogenone B (Zhai, 2020)
13. Leonuketal (Brimble, 2020)
14. New Drugs Approved During 2020 (Pfizer, Takeda, Pharmacodia, 2022)
15. (−)-Phaeocaulisin A (Procter, 2022)
16. (+)-Randainin D (Baudoin, 2024)
17. (+)-Kalmanol (Jia, 2024)
18. Mechanisms by Jerome
19. Melodinus alkaloids (Yokoshima, 2024, Bach, 2008 and Curran, 2011)
20. Phomopsene family (Shi, Hou, Tu, 2023)
21. (–)-Daphenylline (Yang, 2024)

2023

1. Mechanisms by Jerome
2. Cerorubenic Acid-III (Li, 2019)
3. Diazonamide A (MacMillan, 2011)
4. Mechanisms by Jerome
5. (+)-Pedrolide (Carreira, 2023)
6. Mechanisms 
7. (+)-KB343 (Baran, 2023)
8. Pyrrovobasine (Nakamura, 2023)
9. Altemicidin (Maimone, 2021)
10. Retrosynthesis 
11. (+)-Ineleganolide (Stoltz, 2023)
12. (±)-Neofinaconitine (Tan & Gin, 2013)
13. epi-Tetradehydrohalicyclamine B (Fürstner, 2022)
14. Yonarolide (Sarlah, 2023)
15. (−)-Cotylenol (Shenvi, 2023)
16. Mechanisms by Jerome
17. Pleuromutilin (Pronin, 2022)

2022

1. (+)-Ingenol & (+)-Phorbol (Baran, 2013 & 2016)
2. Amycolamicin & Kibdelomycin (Li, 2021)
3. Ladderane Phospholipid (Burns, 2016)
4. Pulvomycin D (Bach, 2021)
5. (-)-10-Hydroxyacutuminine (Reisman, 2022)
6. Shearinines A & G (Carreira, 2022)
7. Corymine & Rubriflordilactone B (Li, 2017; Li, 2017)
8. Weisaconitine D & Liljestrandine (Sarpong, 2015)
9. (-)-Cajanusine (Brown, 2020)
10. (-)-Rhodomollanol A (Ding, 2020)
11. Flueggeacosine B (Han, 2022)
12. Retrosynthesis
13. 10-Hydroxyacutuminine (Reisman, 2022)
14. (+)-Dictyoxetane (Magauer, 2016)
15. Spirochensilide A (Yang, 2020)
16. Isoadenolin I & Isorosthin L (Liang, 2021)
17. Aspidodasycarpine, Lonicerine and Lanciferine (Li, 2016)
18. MedChem retrosyntheses
19. Calyciphylline A (Xu, 2022)
20. Quinine & quinidine (Chen, 2019)
21. (+)-Alstonlarsine (Zhai, 2022)

2021

1. (-)-Vinigrol (Li, 2019 & Baran, 2009)
2. (+)-Pleuromutilin (Reisman, 2018 )
3. (-)-Misramine (Zhou, 2020 )
4. Review on the synthesis of eight-membered carbocycles (Li, 2020 )
5. Avenaol (Tsukano, 2017 )
6. (±)-Phomoidride D (Wood, 2018)
7. (-)-Haliclonin A (Huang, 2016 )
8. Reaction Mechanisms Exercise
9. Industrial Synthesis 12.05.2021
10. Brasilicardin (Tanino, 2018)
11. Prostaglandins (Chen & Zhang, 2021 – Aggarwal, 2012)
12. Bryostatin 3 (Trost, 2020)
13. Industrial Synthesis – Asunaprevir & Entecavir (BMS)
14. Perseanol (Reisman, 2019)
15. Canataxpropellane (Gaish, 2020)
16. (+)-Euphorikanin A (Carreira, 2021)
17. Batrachotoxin (Du Bois, 2016)
18. Pateamine A (Fürstner, 2018)
19. Industrial Synthesis – ELQ-300 & Pyrethroids
20. Clionastatins A and B (Gui, 2021)
21. Cryptotrione (Wong & Peng, 2020)
22. Jerome’s mechanism exercise
23. Shagenes A & B (Tsukano & Takemoto, 2021)
24. Total syntheses starting from Carvone (Lindel, Nicolaou, Tang, Inoue)
25. Bilobalide (Shenvi, 2019)
26. Harziane Diterpenoid (Carreira, 2020)
27. BMS-986251 (BMS, 2021)
28. Xishacorene B (Sarpong, 2021)

2020

1. Curcumalactone (Romo, 2012)
2. Ophioboline (Maimone, 2020)
3. Bryostatine 1 (Wender, 2017)
4. Scabrolide A (Stoltz, 2020)
5. Dichrocephones A and B (Christman, 2018)
6. Tagetitoxin (Baran, 2020)
7. Leustroducsin B (Trost, 2015)
8. (-)-Tetrapetalone A (Wood, 2017)
9. Spirofungin A (Kozmin, 2007)
10. (-)-Acutumine (Herzon, 2013)
11. (-)-Picrotoxinin (Shenvi, 2020, Corey, Yoshikoshi, Trost) Solution
12. (-)-Mitrephorone (Carreira, 2018, Carreira, 2020)
13. Cephanolide A (Gao, 2020)
14. (+)-Waihoensene (Gaich, 2020)
15. Macfarlandin C (Overman, 2020)
16. Mollebenzylanol A (Ito, 2020)

2019

1. (±)-Hippolachnin-A (Trauner, 2017)
2. (-)-Doliculide P (Zhou, 2019)
3. (-)-Ambiguine P (Rawal, 2019)
4. Pleocarpenone & Pleocarpenene (Snapper, 2007)
5. (±)-Erysotramidine (Padwa, 1988).
6. (+)-Psiguadial B (Reisman, 2016).
7. (±)-Limonin (Yamashita, 2015).
8. Aspeverin (Levinson, 2014).

2018

1. (-)-Calyciphylline (Smith, 2014)
2. Communesin F (Movassaghi, 2016)
3. (+)-Psiguadial (Reisman, 2016)
4. Arboridinine (Kam, 2015)
5. Peroranoid (Shen, Yang, Hao, 2016)
6. Nahuoic Acid Ci (Bii) (Smith, 2017)
7. (-)-Isokopsine (Yong Qin, 2017)
8. Guignarderemophilanes C and D (Gademann, 2018).
9. (-)-Acutumine (Herzon, 2013).
10. Neoxaline (Sunazaka, 2018).
11. (±)-Dehaloperophoramidine (Somfai, 2017).
12. Plumisclerin-A (Yao, 2018)

2017

1. Notoamide & Sclerotamide (Li, 2016)
2. Spinosin A (Dai, 2016)
3. Rubriflordilactone B (Li, 2016)
4. Cycloclavine (Wipf, 2017)
5. Eupalinilide E (Siegel, 2016)
6. (+)-Citrinadin B (Wood, 2013)
7. Hyperforin (Shair, 2013)
8. Ovarectaene (Fürstner, 2017)
9. Lancifodilactone G acetate (Yang, 2017)
10. Gelsemoxonine (Fukuyama, 2011)
11. Vigulariol (Clark, 2007)
12. Lycopalhine A (Fukuyama, 2016)
13. (-)-Thiobinupharidine (Zakarian, 2017)
14. Photoredox catalysis as key step in total synthesis of natural products
15. Longeracinphyllin A (Li, 2017)
16. Disciformycin A & B (Fürstner, 2017)

2016

1. Celastrol (Camelio, 2015)
2. Cyperolone (Kirsch, 2012)
3. Epoxyeujindole A (Li, 2015)
4. (+)-Nakadomarin A (Kerr, 2007)
5. (+)-CP-263 (Shair, 2000)

2015

1. Nominine (Gin, 2006)
2. Gracilamine (Gao, 2014)
3. Englerin A (Nicolaou, 2010)
4. Oridamycin (Li, 2014)
5. Ginkolide (Crimmins, 2000)
6. Jiadifenolide (Sorensen, 2014)
7. Roseophilin (Furstner, 1998)
8. Maoecrystal V (Thomson, 2014)
9. Key steps in Total Synthesis I ( )
10. Key steps in Total Synthesis II ( )
11. (-)-hapalindole U & (+)-ambiguine H ( )
12. Welwitindolinone A isonitrile (Wood, 2006)

2014

1. Nakiterpiosin (Chen, 2009)
2. Harringtonolide (Mander, 1998)
3. Daphnilactone (Heathcock, 1989)
4. 7-DeacetoxyalcyoninAcetate (Overman, 1995)
5. Pactamycin (Johnson, 2013)
6. Resiniferatoxin (Wender, 1997)
7. Sieboldine A (Overman, 2010)

2013

1. Flinderoles (Toste, 2011)
2. Gelsemoxonine (Fukuyama, 2011)
3. Echinopine A and B (Mulzer, 2009)
4. Neurymenolide A (Fürstner, 2012)

2012

1. (-)-N-Methylwelwitindolinone C Isothiocyanate (Garg, 2011)
2. Seragakinone A (Suzuki, 2011)
3. Tulearin C (Fürstner, 2011)
4. Hirsutellone B (Nicolaou, 2009)
5. Hopeanol (Snyder, 2012)
6. Pentacycloanammoxic Acid Methylester (Corey, 2004)
7. Guanacastepenes (Carreira, 2011)
8. (-)-FR901483 (Tu, 2012)

2011

1. Streptazolin (Kibayashi, 1996)
2. Cyanthiwigin U (Phillips, 2005)
3. (+)-Laurenyne (Boeckman, 2002)
4. Chlorosulpholipid Cytotoxin (Carreira, 2009)
5. (+)-Liphagal (Stoltz, 2011)
6. Meloscine (Curran, 2011)
7. Hapalindole K (Johnston, 2011)
8. (+)-Omphadiol (Romo, 2011)