The role of the ZRANB3/RNR signaling axis in cancer comes into focus
Our new paper detailing how ZRANB3 is a poignant example of non-oncogene addiction in H-RasG12V-induced transformation and how nuclear RNR-alpha can inhibit this function is set to appear in Cell Chemical Biology. Critically, some approved anti-cancer drugs targeting RNR-alpha such as clofarabine also taps into this pathway: Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axis We (…)
A SPARK of inspiration gave us the chance to JUMP forward
We thank the Swiss National Science Foundation (SNSF)’s pilot funding scheme SPARK, that is designed to promote unconventional projects and uses a new double-blind reviewing process, for supporting our proposed idea, JUMP, among >700 submissions.
Three is not a crowd!
(W)Hu ‘R’ you? A key transcription factor in a druggable pathway is regulated by two mRNA-binding proteins in a mechanism conserved from humans to zebrafish: Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1 Poganik et al. Just Accepted FASEB Journal Gotta get with my friends!: in this invited opinion piece (in Current (…)
Team snatched honours
Jan 2019: At the 2nd PSL International Chemical Biology Symposium at the Curie Institute in Paris, Dr. Xuyu Liu won the poster prize dedicated to Organic and Biological Chemistry Jan 2019: We thank the Novartis Foundation for supporting our ZRANB3-RNR signaling research project March 2019: We thank the Swiss National Science Foundation for Project Funding supporting (…)
Six contributions in a row
March 2019 Our original-research and review contributions to: (1) the inaugural Technological Corner in Trends in Biochemical Sciences, (2) an opinion piece, “Genie in a bottle“, in Current Opinion in Chemical Biology (Chemical Genetics), and (3) ChemBioTalents special issue in ChemBioChem, appear. (4) Our chemical biology primer for the Rising Stars in Chemistry special issue (…)