Dudzic JP, Hanson MA, Iatsenko I, Kondo S, Lemaitre B. (2019) More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila. Cell Rep. 2019 Apr 23;27(4):1050-1061.e3. doi: 10.1016/j.celrep.2019.03.101.
Iatsenko I, Boquete JP, Lemaitre B. (2018) Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan. Immunity. 2018 Nov 20;49(5):929-942.e5. doi: 10.1016/j.immuni.2018.09.017. Epub 2018 Nov 13.
Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B. (2016) PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway. Immunity. 2016 Nov 15;45(5):1013-1023. doi: 10.1016/j.immuni.2016.10.029.
Harumoto T, Lemaitre B. (2018) Male-killing toxin in a bacterial symbiont of Drosophila. Nature. 2018 May;557(7704):252-255. doi: 10.1038/s41586-018-0086-2. Epub 2018 May 2.
Harumoto T, Fukatsu T, Lemaitre B. (2018) Common and unique strategies of male killing evolved in two distinct Drosophila symbionts. Proc Biol Sci. 2018 Mar 28;285(1875). pii: 20172167. doi: 10.1098/rspb.2017.2167.
Harumoto T, Anbutsu H, Lemaitre B, Fukatsu T. (2016) Male-killing symbiont damages host’s dosage-compensated sex chromosome to induce embryonic apoptosis. Nat Commun. 2016 Sep 21;7:12781. doi: 10.1038/ncomms12781.
Melcarne C, Ramond E, Dudzic J, Bretscher AJ, Kurucz É, Andó I, Lemaitre B. (2019) Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster. FEBS J. 2019 Jul;286(14):2670-2691. doi: 10.1111/febs.14857. Epub 2019 May 13.
Dudzic JP, Hanson MA, Iatsenko I, Kondo S, Lemaitre B. (2019) More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila. Cell Rep. 2019 Apr 23;27(4):1050-1061.e3. doi: 10.1016/j.celrep.2019.03.101.
Chakrabarti S, Dudzic JP, Li X, Collas EJ, Boquete JP, Lemaitre B. (2016) Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila. PLoS Genet. 2016 May 27;12(5):e1006089. doi: 10.1371/journal.pgen.1006089. eCollection 2016 May.
Dudzic JP, Kondo S, Ueda R, Bergman CM, Lemaitre B. (2015) Drosophila innate immunity: regional and functional specialization of prophenoloxidases. BMC Biol. 2015 Oct 1;13:81. doi: 10.1186/s12915-015-0193-6.
Garcia-Arraez MG, Masson F, Escobar JCP, Lemaitre B (2019) Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii. BMC Microbiol. 2019 Feb 20;19(1):46
Masson F, Calderon Copete S, Schüpfer F, Garcia-Arraez G, Lemaitre B. (2018) In Vitro Culture of the Insect Endosymbiont Spiroplasma poulsonii Highlights Bacterial Genes Involved in Host-Symbiont Interaction. MBio. 2018 Mar 20;9(2). pii: e00024-18. doi: 10.1128/mBio.00024-18.
Melcarne C, Ramond E, Dudzic J, Bretscher AJ, Kurucz É, Andó I, Lemaitre B (2019) Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster. FEBS J. 2019 Jul;286(14):2670-2691
Ramond E, Maclachlan C, Clerc-Rosset S, Knott GW, Lemaitre B. (2016) Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii. MBio. 2016 Jul 26;7(4). pii: e00881-16.
Ramond E, Meister M, Lemaitre B. (2015) From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle. Dev Cell. 2015 May 26;33(4):367-8
Zhai Z, Boquete JP, Lemaitre B. (2018) Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection.Immunity. 2018 May 15;48(5):897-910.e7. doi: 10.1016/j.immuni.2018.04.010. Epub 2018 May 8.
Zhai Z, Boquete JP, Lemaitre B. (2017) A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila. PLoS Genet. 2017 Jun 29;13(6):e1006854.
Zhai Z, Kondo S, Ha N, Boquete JP, Brunner M, Ueda R, Lemaitre B. (2015) Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat Commun. 2015 Dec 22;6:10219.
Parvy JP, Yu Y, Dostalova A, Kondo S, Kurjan A, Bulet P, Lemaître B, Vidal M, Cordero JB (2019) The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila. Elife. 2019 Jul 30;8. pii: e45061
Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaître B (2019) Correction: Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach. Elife. 2019 May 28;8. pii: e48778. doi: 10.7554/eLife.48778
Dostálová A, Rommelaere S, Poidevin M, Lemaitre B. (2017) Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps. BMC Biol. 2017 Sep 5;15(1):79.
Hamilton PT, Votýpka J, Dostálová A, Yurchenko V, Bird NH, Lukeš J, Lemaitre B, Perlman SJ.(2015) Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. MBio. 2015 Sep 5;6(5):e01356-15.
Chng WA, Koch R, Li X, Kondo S, Nagoshi E, Lemaitre B. (2017) Transforming Growth Factor β/Activin signaling in neurons increases susceptibility to starvation. PLoS One. 2017 Oct 30;12(10):e0187054.
Chng WA, Hietakangas V, Lemaitre B. (2017) Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster. Trends Endocrinol Metab. 2017 Feb;28(2):131-142. doi: 10.1016/j.tem.2016.11.003. Epub 2016 Dec 5. Review.
Chng WA, Sleiman MSB, Schüpfer F, Lemaitre B. (2014) Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Cell Rep. 2014 Oct 9;9(1):336-348
Garcia-Arraez MG, Masson F, Escobar JCP, Lemaitre B (2019) Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii. BMC Microbiol. 2019 Feb 20;19(1):46
C. Paredes, J. K. Herren, F. Schüpfer and B. Lemaitre (2016) The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila in mBio, vol. 7, num. 4, p. e01006-16, 2016.
C. Paredes, J. K. Herren, F. Schuepfer, R. Marin, S. Claverol, C.-H. Kuo, B. Lemaitre and L. Beven (2015) Genome Sequence of the Drosophila melanogaster Male-Killing in Mbio, vol. 6, num. 2, p. e02437-14, 2015.
K. Herren, J. C. Paredes, F. Schuepfer, K. Arafah, P. Bulet and B. Lemaitre (2014) Insect endosymbiont proliferation is limited by lipid availability in Elife, vol. 3, p. e02964, 2014.
Gendrin, A. Zaidman-Remy, N. A. Broderick, J. Paredes, M. Poidevin, A. Roussel and B. Lemaitre. (2013) Functional Analysis of PGRP-LA in Drosophila Immunity in Plos One, vol. 8, num. 7, p. e69742, 2013.
K. Herren, J. C. Paredes, F. Schüpfer and B. Lemaitre. (2011) Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery in mBio, vol. 4, num. 2, p. e00532-12, 2013.
Zaidman-Rémy, M. Poidevin, M. Hervé, D. P. Welchman, J. C. Paredes, C. Fahlander, H. Steiner, D. Mengin-Lecreulx and B. Lemaitre (2011) Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function.. in PloS one, vol. 6, num. 2, p. e17231, 2011.
C. Paredes, D. P. Welchman, M. Poidevin and B. Lemaitre (2011) Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection in Immunity, vol. 35, num. 5, p. 770-9, 2011.
Chakrabarti, J. P. Dudzic, X. Li, E. J. Collas, J.-P. Boquete and B. Lemaitre. (2016) Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila. in PLOS Genetics, vol. 12, num. 5, p. e1006089,
K. Vijendravarma, S. Narasimha, S. Chakrabarti, A. Babin, S. Kolly, B. Lemaitre and T. J. Kawecki. (2015) Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogensin Ecology Letters, vol. 18, num. 10, p. 1078-1086.
Chakrabarti S, Poidevin M, Lemaitre B. The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine. PLoS Genet. 2014 Sep 25;10(9):e1004659.
Chakrabarti S, Liehl P, Buchon N. and Lemaitre B. 2012. Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. Cell Host Microbe 12: 60-70
Buchon, N., Broderick, N.A., Chakrabarti, S., and Lemaitre, B. (2009) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes and Dev. 23: 2333-2344.
Melcarne C, Ramond E, Dudzic J, Bretscher AJ, Kurucz É, Andó I, Lemaitre B. (2019) Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster. FEBS J. 2019 Jul;286(14):2670-2691. doi: 10.1111/febs.14857. Epub 2019 May 13.
J. Bretscher, V. Honti, O. Binggeli, O. Burri, M. Poidevin, E. Kurucz, J. Zsamboki, I. Ando and B. Lemaitre. (2015)The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster in Biology Open, vol. 4, num. 3, p. 355-363.
Neyen, A. J. Bretscher, O. Binggeli and B. Lemaitre. (2014) Methods to study Drosophila immunity in Methods, vol. 68, num. 1, p. 116-128.
Yanagawa A, Neyen C, Lemaitre B, Marion-Poll F. (2017) The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila. PLoS One. 2017 Nov 9;12(11):e0185370.
Neyen and B. Lemaitre. (2016) Sensing Gram-negative bacteria: a phylogenetic perspective in Current Opinion In Immunology, vol. 38, p. 8-17.
Neyen, C. Runchel, F. Schüpfer, P. Meier and B. Lemaitre. (2016) The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors in Nature Immunology, 2016.
Neyen and B. Lemaitre. (2015) Different flavors of Toll guide olfaction in Trends In Immunology, vol. 36, num. 8, p. 439-441.
Neyen C, Binggeli O, Roversi P, Bertin L, Sleiman MB, Lemaitre B. (2014) The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects. Dev Comp Immunol. 24. pii: S0145-305X(14)00320-6.
Binggeli O, Neyen C, Poidevin M, Lemaitre B. (2014) Prophenoloxidase activation is required for survival to microbial infections in Drosophila. PLoS Pathog. 2014 May 1;10(5):e1004067. PMID:
Neyen, C., Bretscher A.J., Binggeli O. and Lemaitre B. (2014) Methods to study Drosophila immunity. Methods. 2014 Jun 15;68(1):116-28.
Aparicio, C. Neyen, B. Lemaitre and A. Busturia. (2013) dRYBP Contributes to the Negative Regulation of the Drosophila Imd Pathway in PloS one, vol. 8, num. 4, p. e62052.
Neyen C, Poidevin M, Roussel A. and Lemaitre B. 2012. Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE. J Immunol 189: 1886-97
C. Paredes, J. K. Herren, F. Schüpfer and B. Lemaitre. (2016) The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila in mBio, vol. 7, num. 4, p. e01006-16, 2016.
C. Paredes, J. K. Herren, F. Schuepfer, R. Marin, S. Claverol, C.-H. Kuo, B. Lemaitre and L. Beven. (2015) Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont in Mbio, vol. 6, num. 2, p. e02437-14.
Herren JK, Paredes JC, Schüpfer F, Arafah K, Bulet P, Lemaitre B. Insect endosymbiont proliferation is limited by lipid availability. Elife. 2014 Jul 15;3:e02964. PMID: 25027439
Herren JK, Paredes JC, Schupfer F, and Lemaitre B. 2013. Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery. MBio 4 Mar 5;4(2). pii: e00532-12.
Herren J. and Lemaitre B. 2012. Insect-microbe interactions: the good, the bad and the others. Curr Opin Microbiol 15: 217-9
Herren, J. and Lemaitre B. (2011) Spiroplasma and host immunity: Activation of humoral immune responses increases endosymbiont load and susceptibility to certain bacterial pathogens in Drosophila melanogaster. Cell. microbiology 13(9):1385-96
S. B. Sleiman, D. Osman, A. Massouras, A. A. Hoffmann, B. Lemaitre and B. Deplancke. (2015) Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence in Nature Communications, vol. 6, p. 7829, 2015.
Osman and N. Buchon. (2014) The unsuspected complexity of the digestive tract of the fruitfly Towards a model of functional regionalization in M S-Medecine Sciences, vol. 30, num. 5, p. 483-485.
Buchon*, N., Osman*, D., David, F.P.A., Fang, H.Y., Boquete, J.P., Deplancke, B. and Lemaitre, B..(2013) Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell report May 30;3(5):1725-38.
Osman D, Buchon N, Chakrabarti S, Huang YT, Su WC, Poidevin M, Tsai YC and Lemaitre B. 2012. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci 125: 5944-9
Neyen, O. Binggeli, P. Roversi, L. Bertin, M. B. Sleiman and B. Lemaitre. (2015) The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects in Developmental And Comparative Immunology, vol. 50, num. 2, p. 166-174.
J. Bretscher, V. Honti, O. Binggeli, O. Burri, M. Poidevin, E. Kurucz, J. Zsamboki, I. Ando and B. Lemaitre. (2015) The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster in Biology Open, vol. 4, num. 3, p. 355-363.
Binggeli, O., C. Neyen, et al. (2014). “Prophenoloxidase activation is required for survival to microbial infections in Drosophila.” PLoS pathogens 10(5): e1004067.
Neyen, A. J. Bretscher, O. Binggeli and B. Lemaitre. (2014) Methods to study Drosophila immunity in Methods, vol. 68, num. 1, p. 116-128.
Kuraishi, T., O. Binggeli, et al. (2011). “Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster.” Proceedings of the National Academy of Sciences of the United States of America 108(38): 15966-15971.
G Dieppois, O Opota, J Lalucat, B Lemaitre (2015) Pseudomonas entomophila: A Versatile Bacterium with Entomopathogenic Properties Pseudomonas, 25-49
Broderick, N.A, Buchon, N and Lemaitre, B (2014) Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology. MBio. 2014 May 27;5(3):e01117-14
Buchon, N., Broderick, N.A. and Lemaitre, B Gut homeostasis in a microbial world: insights from D. melanogaster Nat Rev Microbiol. 2013 11(9):615-26.
Gendrin, A. Zaidman-Remy, N. A. Broderick, J. Paredes, M. Poidevin, A. Roussel and B. Lemaitre. (2013) Functional Analysis of PGRP-LA in Drosophila Immunity in Plos One, vol. 8, num. 7, p. e69742.
A. Broderick and B. Lemaitre. (2012) Gut-associated microbes of Drosophila melanogaster in Gut microbes, vol. 3, num. 4, p. 307-21.
Buchon* N, Broderick* NA, Kuraishi T, and Lemaitre B. (2010). The EGFR pathway coordinates Drosophila stem cell proliferation and gut remodeling in response to infection BMC Biol. 2010 Dec 22;8(1):152.
Broderick N.A., Welchman M., and Lemaitre B (2009). Recognition and response to microbial infection in Drosophila In Insect infection and Immunity, Edited by J. Rolff and S.E. Reynolds. Oxford biology. p13-33.
Buchon, N. A. Broderick, M. Poidevin, S. Pradervand and B. Lemaitre. (2009) Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation in Cell host & microbe, vol. 5, num. 2, p. 200-11.
Buchon, N., Broderick, N.A., Chakrabarti, S., and Lemaitre, B. (2009) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes and Dev. 23: 2333-2344.
Osman and N. Buchon. (2014) The unsuspected complexity of the digestive tract of the fruitfly Towards a model of functional regionalization in M S-Medecine Sciences, vol. 30, num. 5, p. 483-485.
Broderick N.A, Buchon, N and Lemaitre, B (2014) Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology. MBio. 2014 May 27;5(3):e01117-14
Buchon*, N., Osman*, D., David, F.P.A., Fang, H.Y., Boquete, J.P., Deplancke, B. and Lemaitre, B..(2013) Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell report May 30;3(5):1725-38.
Buchon, N., Broderick N.A. and Lemaitre, B. (2013) Gut homeostasis in a microbial world: insights from D. melanogaster Nat Rev Microbiol. 2013 11(9):615-26.
Chakrabarti, P. Liehl, N. Buchon and B. Lemaitre. (2012) Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. in Cell host & microbe, vol. 12, num. 1, p. 60-70.
Osman, N. Buchon, S. Chakrabarti, Y.-T. Huang, W.-C. Su, M. Poidevin, Y.-C. Tsai and B. Lemaitre. (2012) Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division in Journal of cell science, vol. 125, num. 24, p. 5944-5949.
Kuraishi, O. Binggeli, O. Opota, N. Buchon and B. Lemaitre. (2011) Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster in Proceedings of the National Academy of Sciences of the United States of America, vol. 108, num. 38, p. 15966-71.
Buchon, N. A. Broderick, T. Kuraishi and B. Lemaitre. (2010) Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection in BMC biology, vol. 8, num. 1, p. 152.
Buchon, N., Broderick N.A., Poidevin M., Pradervand S. and Lemaitre B (2009). Host defense and stem cell proliferation in the gut of bacteria-infected Drosophila Cell Host & Microbes, 5, 200-211
Buchon N, Poidevin M, Kwon HM, Guillou A, Sottas V, Lee BL, Lemaitre B. (2009) A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci U S A. Jul 28;106(30):12442-7.
Buchon, N., Broderick, N.A., Chakrabarti, S., and Lemaitre, B. (2009) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes and Dev. 23: 2333-2344.
Leone, C. Bebeacua, O. Opota, C. Kellenberger, B. Klaholz, I. Orlov, C. Cambillau, B. Lemaitre and A. Roussel. (2015) X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form in Journal Of Biological Chemistry, vol. 290, num. 21, p. 13191-13201.
Blemont, R. Vincentelli, C. Kellenberger, O. Opota, B. Lemaitre, A. Roussel and P. Leone. (2013) Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila in Acta Crystallographica Section F-Structural Biology And Crystallization Communications, vol. 69, num. 8, p. 930-933.
Kuraishi, O. Binggeli, O. Opota, N. Buchon and B. Lemaitre. (2011) Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster in Proceedings of the National Academy of Sciences of the United States of America, vol. 108, num. 38, p. 15966-71.
Opota, I. Vallet-Gély, R. Vincentelli, C. Kellenberger, I. Iacovache, M. R. Gonzalez, A. Roussel, F.-G. van der Goot and B. Lemaitre. (2011) Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality in PLoS pathogens, vol. 7, num. 9, p. e1002259.
Vallet-Gely I, Opota O, Boniface A, Novikov A, Lemaitre B. (2010) A secondary metabolite acting as a signaling molecule controls Pseudomonas entomophila virulence. Cell Microbiol. 2010 Nov;12(11):1666-7
Kuraishi, T., Binggeli, O., Opota, O. Buchon, N. , and Lemaitre, B. (2011) Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15966-71.
J.-R. Alattia, T. Kuraishi, M. Dimitrov, I. Chang, B. Lemaitre and P. C. Fraering. (2011) Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila in The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 25, num. 7, p. 2287-95.
Buchon N, Broderick NA, Kuraishi T, and Lemaitre B. (2010). The EGFR pathway coordinates Drosophila stem cell proliferation and gut remodeling in response to infection BMC Biol. 2010 Dec 22;8(1):152.
Paredes*, J.C., Welchman*, D.P., Poidevin, P. and Lemaitre, B. (2011) Negative regulation by Amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from its own immune system. Immunity, 23;35(5):770-9
Zaidman-Remy, A., Poidevin, M., Herve, M., Welchman, D.P., Paredes, J.C., Fahlander, C., Steiner, H., Mengin-Lecreulx, D., and Lemaitre, B. (2011). Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. PLoS One 6(2): e17231.
Welchman DP, Aksoy S, Jiggins F, Lemaitre B. (2009) Insect immunity: from pattern recognition to symbiont-mediated host defense.Cell Host Microbe. 2009 Aug 20;6(2):107-14.
Gendrin M., Welchman D., Poidevin M., Hervé M., Lemaitre B. (2009) Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. PLoS Pathog. 2009 Dec;5(12):e1000694
Gendrin M, Zaidman-Rémy A, Broderick NA, Paredes J, Poidevin M, Roussel A, Lemaitre B. (2013) Functional analysis of PGRP-LA in Drosophila immunity. PLoS One. 8(7):e69742.
Gendrin M., Welchman D., Poidevin M., Hervé M., Lemaitre B. (2009) Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. PLoS Pathog. 2009 Dec;5(12):e1000694
Vallet-Gely I., Lemaitre B. and Boccard F. (2008) Bacterial strategies to overcome insect defence systems. Nature Review Microbiol. Apr;6(4):302-13.
Vallet-Gely I, Novikov A, Augusto L, Liehl P, Bolbach G, Péchy-Tarr M, Cosson P, Keel C, Caroff M, Lemaitre B. (2010) Hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, is linked to cyclic lipopeptide production. Appl Environ Microbiol. 76(3):910-21
Vallet-Gely I, Opota O, Boniface A, Novikov A, Lemaitre B. (2010) A secondary metabolite acting as a signaling molecule controls Pseudomonas entomophila virulence. Cell Microbiol. 2010 Nov;12(11):1666-7
Opota, O., Vallet-Gély, I., Vincentelli, R. , Kellenberger C., Iacovache, I.,Gonzalez, M. Roussel, A., van der Goot, F.G. and Lemaitre, B. (2011) Monalysin, a novel b-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality. PLoS Pathog. 2011 Sep;7(9):e1002259
Vallet-Gely I, Opota O, Boniface A, Novikov A, Lemaitre B. (2010) A secondary metabolite acting as a signaling molecule controls Pseudomonas entomophila virulence. Cell Microbiol. 2010 Nov;12(11):1666-7
Zaidman-Remy A., Hervé M., Poidevin M., Pili-Floury S., Kim M-S, Blanot D., Oh B.H., Ueda R., Mengin-Lecreulx D. and B. Lemaitre. (2006) The Drosophila amidase PGRP-LB adjusts the immune response to bacterial infection, Immunity 24(4):463-73.
Zaidman-Remy, A., Poidevin, M., Herve, M., Welchman, D.P., Paredes, J.C., Fahlander, C., Steiner, H., Mengin-Lecreulx, D., and Lemaitre, B. (2011). Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. PLoS One 6(2): e17231.
Stenbak CR, Ryu JH, Leulier F, Pili-Floury S, Parquet C, Herve M, Chaput C, Boneca IG, Lee WJ, Lemaitre B, Mengin-Lecreulx D. (2004) Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol. 173(12):7339-48.
Tang, H., Kambris Z. Lemaitre B. and Hashimoto C. (2008) A serpin that regulates immune melanization in the respiratory system of Drosophila. Dev Cell 15, 617–626.
Scherfer C, Tang H, Kambris Z, Lhocine N, Hashimoto C, Lemaitre B (2008). Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Dev Biol. 323(2):189-96.
Kambris Z., Brun, S., Jang, I.-H., Nam, H.-J., Romeo, Y., Takahashi, K., Lee, W., Ueda, R., and Lemaitre, B. 2006. A large-scale in vivo RNAi screen identifies five new serine proteases required for Toll activation during the Drosophila immune response. Current Biology 6(8):808-13.
Jang IH, Chosa N, Kim SH, Nam HJ, Lemaitre B, Ochiai M, Kambris Z, Brun S, Hashimoto C, Ashida M, Brey PT, Lee WJ. (2006) A spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Dev Cell. 10 (1) :45-55.
Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog 2(6): e56
Vodovar N. Vinals M., Liehl P., Basset A., Degrouard J., Spellman P., Boccard F. and B. Lemaitre.(2005) Drosophila host defense after oral infection by a new entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A. 102:11414-9
Jang IH, Chosa N, Kim SH, Nam HJ, Lemaitre B, Ochiai M, Kambris Z, Brun S, Hashimoto C, Ashida M, Brey PT, Lee WJ. (2006) A spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Dev Cell. 10 (1) :45-55.
Brun, S., Vidal, S., Spellman, P., Ueda, R., Tricoire, H., and Lemaitre, B. 2006. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes to Cells 11. 397-407.
Kambris, K., Brun, S., Jang, I.-H., Nam, H.-J., Romeo, Y., Takahashi, K., Lee, W., Ueda, R., and Lemaitre, B. 2006. A large-scale in vivo RNAi screen identifies five new serine proteases required for Toll activation during the Drosophila immune response. Current Biology 6(8):808-13.
Romeo, Y. and Lemaitre, B. (2008). Drosophila Immunity: Methods for monitoring the activity of Toll and Imd signalling pathway. Methods in Molecular Biology vol 415 Innate Immunity. Edited by Jonathan Ewbank and Eric Vivier Humana Press p379-402
Kambris, Z., Brun, S., Jang, I.-H., Nam, H.-J., Romeo, Y., Takahashi, K., Lee, W., Ueda, R., and Lemaitre, B. 2006. A large-scale in vivo RNAi screen identifies five new serine proteases required for Toll activation during the Drosophila immune response. Current Biology 6(8):808-13.
Vodovar N. Vinals M., Liehl P., Basset A., Degrouard J., Spellman P., Boccard F. and B. Lemaitre.(2005) Drosophila host defense after oral infection by a new entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A. 102:11414-9
Zaidman-Remy A., Hervé M., Poidevin M., Pili-Floury S., Kim M-S, Blanot D., Oh B.H., Ueda R., Mengin-Lecreulx D. and B. Lemaitre. (2006) The Drosophila amidase PGRP-LB adjusts the immune response to bacterial infection, Immunity 24(4):463-73.
Stenbak CR, Ryu JH, Leulier F, Pili-Floury S, Parquet C, Herve M, Chaput C, Boneca IG, Lee WJ, Lemaitre B, Mengin-Lecreulx D. (2004) Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol. 173(12):7339-48.
Chang C.,,Pili-Floury S., Hervé M., Parquet C., Chelliah Y, Lemaitre B., Mengin-Lecreulx D. and J. Deisenhofer. (2004) Structural and functional analysis of the Drosophila pattern-recognition receptor PGRP-SA reveals a peptidoglycan-docking groove for Toll signaling and an unusual L,D-carboxypeptidase activity. PLOS 9: e277
Pili-Floury S, Leulier F, Takahashi K, Saigo K, Samain E, Ueda R, Lemaitre B. (2004) In vivo RNAi analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. J Biol Chem. 2004 279(13):12848-53
Leulier F., Parquet C., Pili-Floury S., Ryu J.-H., Caroff M., Lee W.-J., Mengin-Lecreulx D. and Lemaitre B. The Drosophila immune system detects both Gram-positive and Gram-negative bacteria through specific peptidoglycan recognition. (2003) Nature immunology 4(5):478-84.
Defaye, A.; Evans, I.; Crozatier, M.; Wood, W.; Lemaitre, B.; Leulier, F. (2009) Genetic Ablation of Drosophila Phagocytes Reveals Their Contribution to Both Development and Resistance to Bacterial Infection. J Innate Immun 2009;1:322-334
Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T, Lemaitre B, Gstaiger M, Meier P, Leulier F (2008) Pims Modulates Immune Tolerance to Ingested Bacteria by Negatively Regulating The Drosophila Imd Pathway. Cell Host & Microbes 4:147-58
Geuking P, Narasimamurthy R, Lemaitre B, Basler K, Leulier F. (2009) A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. Geuking P, Narasimamurthy R, Lemaitre B, Basler K, Leulier F. PLoS One. 3;4(11):e7709.
Leulier F, and Lemaitre B. (2008) Toll-like receptors – taking an evolutionary approach. Nature Review Genetics.;9(3):165-78.
Leulier F, Lhocine N, Lemaitre B, Meier P. (2006) The Drosophila IAP DIAP2 Functions in Innate Immunity and is Essential to Resist Gram-negative Bacterial Infection. Mol Cell Biol. 26: 7821-7831.
Stenbak CR, Ryu JH, Leulier F, Pili-Floury S, Parquet C, Herve M, Chaput C, Boneca IG, Lee WJ, Lemaitre B, Mengin-Lecreulx D. (2004) Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol. 173(12):7339-48.
Pili-Floury S, Leulier F, Takahashi K, Saigo K, Samain E, Ueda R, Lemaitre B. (2004) In vivo RNAi analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. J Biol Chem. 2004 279(13):12848-53
Leulier F., Marchal C., Miletich I., Limbourg-Bouchon B., Benarous R. and Lemaitre B. (2003) Directed expression of the HIV-1 accessory protéine Vpu in Drosophila fat body cells inhibits Toll-dependent immune responses. EMBO R 4 : 932-936.
Leulier F., Parquet C., Pili-Floury S., Ryu J.-H., Caroff M., Lee W.-J., Mengin-Lecreulx D. and Lemaitre B. The Drosophila immune system detects both Gram-positive and Gram-negative bacteria through specific peptidoglycan recognition. (2003) Nature immunology 4(5):478-84.
Leulier, F. Vidal S.D., Saigo, K., , Ueda R. and Lemaitre B. (2002) Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Current Biology 12 :996-1000.
Khush RS, Leulier F, Lemaitre B. (2002) Pathogen surveillance- the flies have it. Science, 296: 273-275 (Perpectives).
Vidal, S., Khush, R.S., Leulier, F.,Tzou, P., Nackamura, M., Lemaitre B. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB dependent innate immune responses Genes and Dev. 15: 1900-12.
Khush RS, Leulier F, Lemaitre B. (2001)Drosophila immunity: two paths to NF-kB. Trends in Immunology, 22: 260-264.
Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B. (2000)The Drosophila caspase Dredd is required to resist to Gram negative bacterial infection. EMBO R 4 : 353-358.
Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog 2(6): e56
Vodovar N. Vinals M., Liehl P., Basset A., Degrouard J., Spellman P., Boccard F. and B. Lemaitre.(2005) Drosophila host defense after oral infection by a new entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A. 102:11414-9
Vodovar N., Acosta C., Lemaitre B. and Boccard F. (2004) Drosophila, a polyvalent model to decipher host-pathogen interactions. Trends in microbial. 12(5):235-42.
Vodovar, N., Vallenet, D., Cruveiller, S., Rouy, Z., Barbe, V., Acosta, C., Cattolico, L., Jubin, C., Lajus, A., Segurens, B., Vacherie, B., Wincker, P., Weissenbach, J., Lemaitre, B., Médigue, C., and Boccard, F. 2006. The complete genome sequence of the entomopatogenic and metabolically versatile soil bacterium Pseudomonas entomophila. Nature Biotech 4(6):673-9.
De Gregorio E, Lemaitre B. (2002) The mosquito genome: the post-genomic era opens. Nature. 419:496-7.
De Gregorio E., HanS.-J, Lee W.-J., Baek M.-L., Osaki T., Kawabata S.I., Lee B.-L., IwanagaS., Lemaitre B. and Brey P.T. (2002)An immune responsive serpin regulates the melanization cascade in Drosophila host defense. Developmental Cell 3: 581-592.
De Gregorio E., Spellman P.T., Tzou, P.T. Rubin G.M., Lemaitre B. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila adults. EMBO J 21 : 2568-2579.
Tzou P., De Gregorio E., Lemaitre B. (2002) How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions. Current Opinion in Microbiology 5 : 102-110.
De Gregorio E., Spellman P.T., Rubin G.M., Lemaitre B. (2001) Genome-wide analysis of the Drosophila immune response using oligonucleotide microarrays. Proc Natl Acad Sci U S A. 98 : 12590-95.
Basset A., Tzou P., Lemaitre B. and Boccard F. (2003) A single gene that promotes interactions of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster.. Embo R 4:205-209.
De Gregorio E., Spellman P.T., Tzou, P.T. Rubin G.M., Lemaitre B. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila adults. EMBO J 21 : 2568-2579.
Tzou P., Reicchart J.M.., Lemaitre B. (2002) Overexpression of a single antimicrobial peptide restores wild-type resistance to infection in immuno-deficient Drosophila mutants. Proc Natl Acad Sci U S A. Proc 99:2152-2157.
Tzou P., Meister M., Lemaitre B. (2002) Methods for studying infection and immunity in Drosophila. Methods in Microbiology 31: 507-529.
Tzou P., De Gregorio E., Lemaitre B. (2002) How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions. Current Opinion in Microbiology 5 : 102-110.
Vidal, S., Khush, R.S., Leulier, F.,Tzou, P., Nackamura, M., Lemaitre B. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB dependent innate immune responses Genes and Dev. 15: 1900-12.
Tzou, P., Ohresser S., Ferrandon D., Capovilla M., Reichhart J.M., Lemaitre B., Hoffmann J.A., Imler J.L. (2000). Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13, 737-748
Brun, S., Vidal, S., Spellman, P., Ueda, R., Tricoire, H., and Lemaitre, B. 2006. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes to Cells 11. 397-407.
Leulier, F. Vidal S.D., Saigo, K., , Ueda R. and Lemaitre B. (2002) Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Current Biology 12 :996-1000.
Vidal, S., Khush, R.S., Leulier, F.,Tzou, P., Nackamura, M., Lemaitre B. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB dependent innate immune responses Genes and Dev. 15: 1900-12.
Ranjiv S. Khush R.S., Cornwell W.D., Uram J.N, and Lemaitre B. (2002) A Ubiquitin-Proteasome Pathway Represses the Drosophila Immune Deficiency Signaling Cascade. Current Biology 12 :1728-37.
Khush RS, Leulier F, Lemaitre B. (2002) Pathogen surveillance- the flies have it. Science, 296: 273-275 (Perpectives).
Vidal, S., Khush, R.S., Leulier, F.,Tzou, P., Nackamura, M., Lemaitre B. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB dependent innate immune responses Genes and Dev. 15: 1900-12.
Khush RS, Leulier F, Lemaitre B. (2001)Drosophila immunity: two paths to NF-kB. Trends in Immunology, 22: 260-264.
Khush RS, Lemaitre B. (2000) Genes that fight infection: what the Drosophila genome says about animal immunity Trends in Genetics 16 : 442-449.
Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B. (2000)The Drosophila caspase Dredd is required to resist to Gram negative bacterial infection. EMBO R 4 : 353-358.
Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. (2000) The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci U S A., 97 (7):3376-3381.
Vodovar N. Vinals M., Liehl P., Basset A., Degrouard J., Spellman P., Boccard F. and B. Lemaitre.(2005) Drosophila host defense after oral infection by a new entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A. 102:11414-9
Basset A., Tzou P., Lemaitre B. and Boccard F. (2003) A single gene that promotes interactions of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster.. Embo R 4:205-209.
Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. (2000) The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci U S A., 97 (7):3376-3381.
Manfruelli, P., Reichhart J. M., Steward, R., Hoffmann J.A., and Lemaitre B. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and Dif. EMBO J 18, 3380-91.
Lemaitre B., Kromer-Metzger E., Michaut L., Nicolas E., Meister M., Georgel P., Reichhart J.M. and Hoffmann J.A. (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. USA 92:9465-9469.
Nicolas E., Nappi A.J. and Lemaitre B. (1996) Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila. Develop. Comp. Immunol. 20:175-181.
Lemaitre B., Nicolas E., Michaut L., Reichhart J.M. and Hoffmann J.A. (1996) The dorsoventral regulatory gene cassette spaetzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983.
Nicolas, E., Reichhart J. M., Hoffmann J.A., and Lemaitre B. (1998).In vivo regulation of the IkB homologue cactus during the immune response of Drosophila.. J Biol. Chem 273, 10463-10469.