Erectile dysfunction (ED) is a widespread multi-causal disorder, that affects many men worldwide. Over 66 million men in EU and US suffer from ED, while 30% of them are non-responsive to oral drugs. Men non-responsive to drugs resort to penile implants or intra-penile injections of vasodilators. However, penile implants require an invasive and destructive procedure, which is irreversible, whereas intra-penile injections may cause pain, bleeding, penile fibrosis, which can worsen ED or even lead to priapism. There is clearly a need for providing better therapeutic strategies for treating ED. Our laboratory is currently developing highly innovative approaches to offer better solutions to these patients, varying from medical devices to pharmacological agents.