Metabolic reactions are the end-product of protein and gene expression and often at the heart of many diseases. Our lab is interested in the non-invasive measurement of metabolic processes and function. We are developing new approaches (multinuclear spin physics and metabolic modeling, among others) allowing to measure metabolic reactions in vivo hitherto inaccessible, in the context of biomedical problems of interest in rodent models of health and disease (neurochemistry and diabetes research, among others), as well as with human volunteer subjects.