Publications

2023

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

R. V. Fernandes; J. Lingner 

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad448.

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2022

TFIIH moonlighting at telomeres

G. Glousker; J. Lingner 

Genes & Development. 2022. Vol. 36, num. 17-18, p. 951 – 953. DOI : 10.1101/gad.350140.122.

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2021

The human telomeric proteome during telomere replication

C-Y. G. Lin; A. C. Naeger; T. Lunardi; A. Vancevska; G. Lossaint et al. 

Nucleic Acids Research. 2021. Vol. 49, num. 21, p. 12119 – 12135. DOI : 10.1093/nar/gkab1015.

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The makings of TERRA R-loops at chromosome ends

R. V. Fernandes; M. Feretzaki; J. Lingner 

Cell Cycle. 2021. Vol. 20, num. 18, p. 1745 – 1759. DOI : 10.1080/15384101.2021.1962638.

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Challenging endings: How telomeres prevent fragility

G. Glousker; J. Lingner 

Bioessays. 2021.  p. e2100157. DOI : 10.1002/bies.202100157.

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A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres

E. Mentegari; F. Bertoletti; M. Kissova; E. Zucca; S. Galli et al. 

International Journal of Molecular Sciences. 2021. Vol. 22, num. 5, p. 2365. DOI : 10.3390/ijms22052365.

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2020

PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage

W. Ahmed; J. Lingner 

Cell Reports. 2020. Vol. 33, num. 5, p. 108347. DOI : 10.1016/j.celrep.2020.108347.

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Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair

G. Glousker; A-S. Briod; M. Quadroni; J. Lingner 

Embo Journal. 2020.  p. e104500. DOI : 10.15252/embj.2020104500.

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RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

M. Feretzaki; M. Pospisilova; R. Valador Fernandes; T. Lunardi; L. Krejci et al. 

Nature. 2020. Vol. 587, num. 7833, p. 303 – 308. DOI : 10.1038/s41586-020-2815-6.

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SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres

A. Vancevska; W. Ahmed; V. Pfeiffer; M. Feretzaki; S. J. Boulton et al. 

Embo Journal. 2020.  p. e102668. DOI : 10.15252/embj.2019102668.

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2019

Expression and differential regulation of human TERRA at several chromosome ends

M. Feretzaki; P. R. Nunes; J. Lingner 

RNA. 2019. Vol. 25, num. 11, p. 1470 – 1480. DOI : 10.1261/rna.072322.119.

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CSL controls telomere maintenance and genome stability in human dermal fibroblasts

G. Bottoni; A. Katarkar; B. Tassone; S. Ghosh; A. Clocchiatti et al. 

Nature Communications. 2019. Vol. 10, p. 3884. DOI : 10.1038/s41467-019-11785-7.

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2018

Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1

J. Majerska; M. Feretzaki; G. Glousker; J. Lingner 

Life Science Alliance. 2018. Vol. 1, num. 4, p. e201800121. DOI : 10.26508/lsa.201800121.

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PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

W. Ahmed; J. Lingner 

Genes & Development. 2018. Vol. 32, num. 9-10, p. 658 – 669. DOI : 10.1101/gad.313460.118.

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When Telomerase Causes Telomere Loss

G. Glousker; J. Lingner 

Developmental Cell. 2018. Vol. 44, num. 3, p. 281 – 283. DOI : 10.1016/j.devcel.2018.01.011.

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Impact of oxidative stress on telomere biology

W. Ahmed; J. Lingner 

Differentiation. 2018. Vol. 99, p. 21 – 27. DOI : 10.1016/j.diff.2017.12.002.

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2017

TZAP or not to zap telomeres

G. Lossaint; J. Lingner 

Science (New York, N.Y.). 2017. Vol. 355, num. 6325, p. 578 – 579. DOI : 10.1126/science.aam7015.

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A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

M. Feretzaki; J. Lingner 

Methods. 2017. Vol. 114, p. 39 – 45. DOI : 10.1016/j.ymeth.2016.08.004.

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Quantitative telomeric chromatin isolation protocol for human cells

J. Majerská; S. Redon; J. Lingner 

Methods. 2017. Vol. 114, p. 28 – 38. DOI : 10.1016/j.ymeth.2016.08.003.

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The telomeric DNA damage response occurs in the absence of chromatin decompaction

A. Vancevska; K. M. Douglass; V. Pfeiffer; S. Manley; J. Lingner 

Genes and Development. 2017. Vol. 31, num. 6, p. 567 – 577. DOI : 10.1101/gad.294082.116.

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2016

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

E. Aeby; W. Ahmed; S. Redon; V. Simanis; J. Lingner 

Cell Reports. 2016. Vol. 17, num. 12, p. 3107 – 3114. DOI : 10.1016/j.celrep.2016.11.071.

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2015

Telomere functions grounding on TERRA firma

C. M. Azzalin; J. Lingner 

Trends In Cell Biology. 2015. Vol. 25, num. 1, p. 29 – 36. DOI : 10.1016/j.tcb.2014.08.007.

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ALT Telomeres Get Together with Nuclear Receptors

E. Aeby; J. Lingner 

Cell. 2015. Vol. 160, num. 5, p. 811 – 3. DOI : 10.1016/j.cell.2015.02.006.

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2014

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

A. Porro; S. Feuerhahn; J. Lingner 

Cell reports. 2014. Vol. 6, num. 4, p. 765 – 76. DOI : 10.1016/j.celrep.2014.01.022.

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The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7

I. Zemp; J. Lingner 

Journal of Biological Chemistry. 2014. Vol. 289, num. 41, p. 28595 – 28606. DOI : 10.1074/jbc.M114.596056.

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Functional characterization of the TERRA transcriptome at damaged telomeres

A. Porro; S. Feuerhahn; J. Delafontaine; H. Riethman; J. Rougemont et al. 

Nature Communications. 2014. Vol. 5, p. 5379. DOI : 10.1038/ncomms6379.

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2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

S. Redon; I. Zemp; J. Lingner 

Nucleic acids research. 2013. Vol. 41, num. 19, p. 9117 – 9128. DOI : 10.1093/nar/gkt695.

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Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

A. Gupta; S. Sharma; P. Reichenbach; L. Marjavaara; A. K. Nilsson et al. 

Genetics. 2013. Vol. 193, num. 4, p. 1095 – 105. DOI : 10.1534/genetics.112.149120.

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Molecular basis of telomere syndrome caused by CTC1 mutations

L-Y. Chen; J. Majerska; J. Lingner 

Genes & Development. 2013. Vol. 27, num. 19, p. 2099 – 2108. DOI : 10.1101/gad.222893.113.

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A quantitative telomeric chromatin isolation protocol identifies different telomeric states

L. Grolimund; E. Aeby; R. Hamelin; F. Armand; D. Chiappe et al. 

Nature Communications. 2013. Vol. 4, p. 2848. DOI : 10.1038/ncomms3848.

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Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

M. Makhlouf Brahmi; C. Portmann; D. D’Ambrosio; T. M. Woods; D. Banfi et al. 

Chemistry – A European Journal. 2013. Vol. 19, num. 14, p. 4596 – 4601. DOI : 10.1002/chem.201203296.

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Replication of Telomeres and the Regulation of Telomerase

V. Pfeiffer; J. Lingner 

Cold Spring Harbor Perspectives in Biology. 2013. Vol. 5, num. 5, p. a010405. DOI : 10.1101/cshperspect.a010405.

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The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

V. *Pfeiffer; J. *Crittin; L. Grolimund; J. Lingner 

Embo Journal. 2013. Vol. 32, num. 21, p. 2861 – 2871. DOI : 10.1038/emboj.2013.217.

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CST for the grand finale of telomere replication

L-Y. Chen; J. Lingner 

Nucleus-Austin. 2013. Vol. 4, num. 4, p. 277 – 282. DOI : 10.4161/nucl.25701.

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Structure of active dimeric human telomerase

A. **Sauerwald; S. **Sandin; G. Cristofari; S. H. W. Scheres; J. *Lingner et al. 

Nature Structural & Molecular Biology. 2013. Vol. 20, num. 4, p. 454 – 460. DOI : 10.1038/nsmb.2530.

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2012

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

D. D’Ambrosio; P. Reichenbach; E. Micheli; A. Alvino; M. Franceschin et al. 

Biochimie. 2012. Vol. 94, p. 854 – 863. DOI : 10.1016/j.biochi.2011.12.004.

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TERRA Promotes Telomere Shortening through Exonuclease 1-Mediated Resection of Chromosome Ends

V. Pfeiffer; J. Lingner 

Plos Genetics. 2012. Vol. 8, num. 6, p. e1002747. DOI : 10.1371/journal.pgen.1002747.

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The human CST complex is a terminator of telomerase activity

L-Y. Chen; S. Redon; J. Lingner 

Nature. 2012. Vol. 488, num. 7412, p. 540 – 4. DOI : 10.1038/nature11269.

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AUF1/HnRNP D RNA Binding Protein Functions in Telomere Maintenance

L-Y. Chen; J. Lingner 

Molecular Cell. 2012. Vol. 47, p. 1 – 2. DOI : 10.1016/j.molcel.2012.06.031.

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2011

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

H. C. Ferreira; B. Luke; H. Schober; V. Kalck; J. Lingner et al. 

Nature Cell Biology. 2011. Vol. 13, num. 7, p. 867 – 874. DOI : 10.1038/ncb2263.

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Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast

N. Iglesias; S. Redon; V. Pfeiffer; M. Dees; J. Lingner et al. 

EMBO reports. 2011. Vol. 12, num. 6, p. 587 – 93. DOI : 10.1038/embor.2011.73.

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Roles of telomeres and telomerase in cancer

J. Lingner 

Swiss Cancer Bulletin. 2011. Vol. 1/2011, p. 70 – 74.

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2010

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

S. Redon; P. Reichenbach; J. Lingner 

Nucleic acids research. 2010. Vol. 38, num. 17, p. 5797 – 806. DOI : 10.1093/nar/gkq296.

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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

E. Abreu; E. Aritonovska; P. Reichenbach; G. Cristofari; B. Culp et al. 

Molecular and cellular biology. 2010. Vol. 30, num. 12, p. 2971 – 82. DOI : 10.1128/MCB.00240-10.

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Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways

A. Porro; S. Feuerhahn; P. Reichenbach; J. Lingner 

Molecular and cellular biology. 2010. Vol. 30, num. 20, p. 4808 – 17. DOI : 10.1128/MCB.00460-10.

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TERRA biogenesis, turnover and implications for function

S. Feuerhahn; N. Iglesias; A. Panza; A. Porro; J. Lingner 

FEBS letters. 2010. Vol. 584, num. 17, p. 3812 – 8. DOI : 10.1016/j.febslet.2010.07.032.

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2009

Related mechanisms for end processing at telomeres and DNA double-strand breaks

N. Iglesias; J. Lingner 

Mol. Cell. 2009. Vol. 35, num. 2, p. 137 – 138. DOI : 10.1016/j.molcel.2009.07.007.

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TERRA: telomeric repeat-containing RNA

B. Luke; J. Lingner 

EMBO Journal. 2009. Vol. 2, num. 28, p. 2503 – 2510. DOI : 10.1038/emboj.2009.166.

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Telomerase is essential to alleviate pif1-induced replication stress at telomeres

M. Chang; B. Luke; C. Kraft; Z. Li; M. Peter et al. 

Genetics. 2009. Vol. 183, num. 3, p. 779 – 791. DOI : 10.1534/genetics.109.107631.

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2008

Cell signaling: Tel2 finally tells one story

M. Chang; J. Lingner 

Science. 2008. Vol. 320, num. 5872, p. 60 – 61. DOI : 10.1126/science.1155132.

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Telomeres: the silence is broken

C. M. Azzalin; J. Lingner 

Cell Cycle. 2008. Vol. 7, p. 1161 – 1165. DOI : 10.4161/cc.7.9.5836.

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The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae

B. Luke; A. Panza; S. Redon; N. Iglesias; Z. Li et al. 

Mol. Cell. 2008. Vol. 32, num. 4, p. 465 – 477. DOI : 10.1016/j.molcel.2008.10.019.

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2007

Telomerase unplugged

G. Cristofari; K. Sikora; J. Lingner 

ACS Chemical Biololgy. 2007. Vol. 2, num. 3, p. 155 – 8. DOI : 10.1021/cb700037c.

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Low- to high-throughput analysis of telomerase modulators with Telospot

G. Cristofari; P. Reichenbach; P. O. Regamey; D. Banfi; M. Chambon et al. 

Nature Methods. 2007. Vol. 4, num. 10, p. 851 – 853. DOI : 10.1038/nmeth1099.

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Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast

M. Arneric; J. Lingner 

EMBO Rep. 2007. Vol. 8, num. 11, p. 1080 – 1085. DOI : 10.1038/sj.embor.7401082.

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Molecular biology: damage control

C. M. Azzalin; J. Lingner 

Nature. 2007. Vol. 448, num. 7157, p. 1001 – 2. DOI : 10.1038/4481001a.

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Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae

M. Chang; M. Arneric; J. Lingner 

Genes & Development. 2007. Vol. 21, num. 19, p. 2485 – 2494. DOI : 10.1101/gad.1588807.

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Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

G. Cristofari; E. Adolf; P. Reichenbach; K. Sikora; R. M. Terns et al. 

Molecular Cell. 2007. Vol. 27, num. 6, p. 882 – 9. DOI : 10.1016/j.molcel.2007.07.020.

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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

A. De Cian; G. Cristofari; P. Reichenbach; E. De Lemos; D. Monchaud et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2007. Vol. 104, num. 44, p. 17347 – 17352. DOI : 10.1073/pnas.0707365104.

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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

C. M. Azzalin; P. Reichenbach; L. Khoriauli; E. Giulotto; J. Lingner 

Science. 2007. Vol. 318, num. 5851, p. 798 – 801. DOI : 10.1126/science.1147182.

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Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense mediated mRNA decay

B. Luke; C. M. Azzalin; N. Hug; A. Deplazes; M. Peter et al. 

Nucleic Acids Res.. 2007. Vol. 35, num. 22, p. 7688 – 7697. DOI : 10.1093/nar/gkm912.

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Protein-RNA and protein-protein interactions mediate association of human EST1A/SMG6 with telomerase

S. Redon; P. Reichenbach.; J. Lingner 

Nucleic Acids Res.. 2007. Vol. 35, num. 20, p. 7011 – 7022. DOI : 10.1093/nar/gkm724.

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2006

Telomere length homeostasis requires that telomerase levels are limiting

G. Cristofari; J. Lingner 

EMBO Journal. 2006. Vol. 25, num. 3, p. 565 – 574. DOI : 10.1038/sj.emboj.7600952.

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The double life of UPF1 in RNA and DNA stability pathways

C. M. Azzalin; J. Lingner 

Cell Cycle. 2006. Vol. 5, num. 14, p. 1496 – 1498. DOI : 10.4161/cc.5.14.3093.

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The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation

A. Eugster; C. Lanzuolo; M. Bonneton; P. Luciano; A. Pollice et al. 

Nat Struct Mol Biol. 2006. Vol. 13, num. 8, p. 734 – 9. DOI : 10.1038/nsmb1126.

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Telomere length homeostasis

N. Hug; J. Lingner 

Chromosoma. 2006. Vol. 115, num. 6, p. 413 – 425. DOI : 10.1007/s00412-006-0067-3.

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The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

C. M. Azzalin; J. Lingner 

Current Biology. 2006. Vol. 16, num. 4, p. 433 – 9. DOI : 10.1016/j.cub.2006.01.018.

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2005

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

C. Kelleher; I. Kurth; J. Lingner 

Molecular and Cellular Biology. 2005. Vol. 25, num. 2, p. 808 – 18. DOI : 10.1128/MCB.25.2.808-818.2005.

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Telomerase limits the extent of base pairing between template RNA and telomeric DNA

K. Förstemann; J. Lingner 

EMBO Reports. 2005. Vol. 6, num. 4, p. 361 – 366. DOI : 10.1038/sj.embor.7400374.

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2004

Cell biology. Telomere wedding ends in divorce

C. M. Azzalin; J. Lingner 

Science. 2004. Vol. 304, num. 5667, p. 60 – 2. DOI : 10.1126/science.1096809.

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Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States

M. T. Teixeira; M. Arneric; P. Sperisen; J. Lingner 

Cell. 2004. Vol. 117, num. 3, p. 323 – 35. DOI : 10.1016/S0092-8674(04)00334-4.

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2003

Yeast telomerase is specialized for C/A-rich RNA templates

K. Förstemann; A. J. Zaug; T. R. Cech; J. Lingner 

Nucleic Acids Res. 2003. Vol. 31, num. 6, p. 1646 – 55. DOI : 10.1093/nar/gkg261.

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A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin

H. Szutorisz; J. Lingner; A. P. Cuthbert; D. A. Trott; R. F. Newbold et al. 

Cancer Research. 2003. Vol. 63, num. 3, p. 689 – 95.

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A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed

P. Reichenbach; M. Hoss; C. M. Azzalin; M. Nabholz; P. Bucher et al. 

Current Biology. 2003. Vol. 13, num. 7, p. 568 – 74. DOI : 10.1016/S0960-9822(03)00173-8.

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Fingering the ends. How to make new telomeres

G. Cristofari; J. Lingner 

Cell. 2003. Vol. 113, num. 5, p. 552 – 4. DOI : 10.1016/S0092-8674(03)00397-0.

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2002

Detection of promoter activity by flow cytometric analysis of GFP reporter expression

A. L. Ducrest; M. Amacker; J. Lingner; M. Nabholz 

Nucleic Acids Res. 2002. Vol. 30, num. 14, p. e65. DOI : 10.1093/nar/gnf064.

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Telomerase: biochemical considerations for enzyme and substrate

C. Kelleher; M. T. Teixeira; K. Förstemann; J. Lingner 

Trends Biochem Sci. 2002. Vol. 27, num. 11, p. 572 – 9. DOI : 10.1016/S0968-0004(02)02206-5.

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate

E. Pascolo; C. Wenz; J. Lingner; N. Hauel; H. Priepke et al. 

Journal of Biological Chemistry. 2002. Vol. 277, num. 18, p. 15566 – 72.. DOI : 10.1074/jbc.M201266200.

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Regulation of the human telomerase reverse transcriptase gene

A. L. Ducrest; H. Szutorisz; J. Lingner; M. Nabholz 

Oncogene. 2002. Vol. 21, num. 4, p. 541 – 52. DOI : 10.1038/sj.onc.1205081.

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Intracellular trafficking of yeast telomerase components

M. T. Teixeira; K. Förstemann; S. M. Gasser; J. Lingner 

EMBO Rep. 2002. Vol. 3, num. 7, p. 652 – 9. DOI : 10.1093/embo-reports/kvf133.

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2001

Human telomerase contains two cooperating telomerase RNA molecules

C. Wenz; B. Enenkel; M. Amacker; C. Kelleher; K. Damm et al. 

EMBO Journal. 2001. Vol. 20, num. 13, p. 3526 – 34. DOI : 10.1093/emboj/20.13.3526.

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

K. Damm; U. Hemmann; P. Garin-Chesa; N. Hauel; I. Kauffmann et al. 

EMBO Journal. 2001. Vol. 20, num. 24, p. 6958 – 68. DOI : 10.1093/emboj/20.24.6958.

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Molecular basis for telomere repeat divergence in budding yeast

K. Förstemann; J. Lingner 

Molecular and Cellular Biology. 2001. Vol. 21, num. 21, p. 7277 – 7286. DOI : 10.1128/MCB.21.21.7277-7286.2001.

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Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

H. Szutorisz; R. Palmqvist; G. Roos; R. Stenling; D. F. Schorderet et al. 

Oncogene. 2001. Vol. 20, num. 20, p. 2600 – 5. DOI : 10.1038/sj.onc.1204346.

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Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity

A. L. Ducrest; M. Amacker; Y. D. Mathieu; A. P. Cuthbert; D. A. Trott et al. 

Cancer Research. 2001. Vol. 61, num. 20, p. 7594 – 602.

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2000

Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres

K. Förstemann; M. Hoss; J. Lingner 

Nucleic Acids Res. 2000. Vol. 28, num. 14, p. 2690 – 4. DOI : 10.1093/nar/28.14.2690.

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Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting

S. Aigner; J. Lingner; K. J. Goodrich; C. A. Grosshans; A. Shevchenko et al. 

EMBO Journal. 2000. Vol. 19, num. 22, p. 6230 – 9. DOI : 10.1093/emboj/19.22.6230.

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1999

Direct activation of TERT transcription by c-MYC

K. J. Wu; C. Grandori; M. Amacker; N. Simon-Vermot; A. Polack et al. 

Nature Genetics. 1999. Vol. 21, num. 2, p. 220 – 224. DOI : 10.1038/6010.

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Telomeres and telomerase

M. A. Blasco; S. M. Gasser; J. Lingner 

Genes & Development. 1999. Vol. 13, num. 18, p. 2353 – 9. DOI : 10.1101/gad.13.18.2353.

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1998

Telomerase and chromosome end maintenance

J. Lingner; T. R. Cech 

Current Opinion in Genetics & Development. 1998. Vol. 8, num. 2, p. 226 – 32. DOI : 10.1016/S0959-437X(98)80145-7.

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Telomerase : the reverse transcriptase subunit as a key to enzymatic function and regulation during cell immortalization

J. Lingner 

Swiss Cancer Bulletin. 1998. Vol. 18, p. 38 – 42.

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1997

Telomerase is a true reverse transcriptase. A review

T. R. Cech; T. M. Nakamura; J. Lingner 

Biochemistry (Mosc). 1997. Vol. 62, num. 11, p. 1202 – 5.

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Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity

J. Lingner; T. R. Cech; T. R. Hughes; V. Lundblad 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 1997. Vol. 94, num. 21, p. 11190 – 5. DOI : 10.1073/pnas.94.21.11190.

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Telomerase catalytic subunit homologs from fission yeast and human

T. M. Nakamura; G. B. Morin; K. B. Chapman; S. L. Weinrich; W. H. Andrews et al. 

Science. 1997. Vol. 277, num. 5328, p. 955 – 9. DOI : 10.1126/science.277.5328.955.

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Reverse transcriptase motifs in the catalytic subunit of telomerase

J. Lingner; T. R. Hughes; A. Shevchenko; M. Mann; V. Lundblad et al. 

Science. 1997. Vol. 276, num. 5312, p. 561 – 7. DOI : 10.1126/science.276.5312.561.

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Telomerase and the chromosome end replication problem

T. R. Cech; J. Lingner 

Ciba Found Symp. 1997. Vol. 211, p. 20 – 8; discussion 28. DOI : 10.1002/9780470515433.ch3.

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1996

Purification of telomerase from Euplotes aediculatus: requirement of a primer 3′ overhang

J. Lingner; T. R. Cech 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 1996. Vol. 93, num. 20, p. 10712 – 7. DOI : 10.1073/pnas.93.20.10712.

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Method for determining RNA 3′ ends and application to human telomerase RNA

A. J. Zaug; J. Lingner; T. R. Cech 

Nucleic Acids Res. 1996. Vol. 24, num. 3, p. 532 – 3. DOI : 10.1093/nar/24.3.532.

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1995

The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase

P. J. Preker; J. Lingner; L. Minvielle-Sebastia; W. Keller 

Cell. 1995. Vol. 81, num. 3, p. 379 – 89. DOI : 10.1016/0092-8674(95)90391-7.

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Telomerase and DNA end replication: no longer a lagging strand problem?

J. Lingner; J. P. Cooper; T. R. Cech 

Science. 1995. Vol. 269, num. 5230, p. 1533 – 1534. DOI : 10.1126/science.7545310.

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1994

Telomerase RNAs of different ciliates have a common secondary structure and a permuted template

J. Lingner; L. L. Hendrick; T. R. Cech 

Genes & Development. 1994. Vol. 8, num. 16, p. 1984 – 98. DOI : 10.1101/gad.8.16.1984.

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1993

3′-end labeling of RNA with recombinant yeast poly(A) polymerase

J. Lingner; W. Keller 

Nucleic Acids Res. 1993. Vol. 21, num. 12, p. 2917 – 20. DOI : 10.1093/nar/21.12.2917.

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1991

Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae

J. Lingner; J. Kellermann; W. Keller 

Nature. 1991. Vol. 354, num. 6353, p. 496 – 8. DOI : 10.1038/354496a0.

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Purification and characterization of poly(A) polymerase from Saccharomyces cerevisiae

J. Lingner; I. Radtke; E. Wahle; W. Keller 

Journal of Biological Chemistry. 1991. Vol. 266, num. 14, p. 8741 – 8746. DOI : 10.1016/S0021-9258(18)31508-4.

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1989

Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes

C. Price; J. Lingner; T. A. Bickle; K. Firman; S. W. Glover 

Journal of Molecular Biology. 1989. Vol. 205, num. 1, p. 115 – 25. DOI : 10.1016/0022-2836(89)90369-0.

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