Where generative AI meets molecular biology
Here at EPFL, we’re more than just studying life—we’re actively designing it!
Our group of around 30 students, divided into different projects such as kinase engineering, metabolism engineering, and binder design, are utilizing new generative AI models in the field of Life Sciences to conduct cutting-edge research. We are working under the guidance of professors and PhD students here at EPFL.
What would you do in this project ?
If you join us on this project, you will enter the large and promising world of protein design!
You will first do some research to find an idea of useful protein structure, or begin a project after a suggestion from a professor, or industry! You will then learn how to use AI to generate your original protein structure, and you will finally check if your protein works according to your prediction, testing it in wet Lab.
If you join this project, you will benefit from the help and advices of old members and have the opportunity to use all required materials for your experiments. After some time hopefully you will become a mentor yourself and it would be your turn to help new students taking their first steps into the world of research!
For more information about our current and past projects, news, team members, or how to join us, please visit our website here:
(to come soon)
We look forward to hear from you!
Interesting articles for current members
AI tools for protein design
- News and views – promise
Callaway Nature 2023
Added: 2023-09-20 - News and views – critique
Arnold Nature 2023
Added: 2023-09-23 - Surface fingerprints
Gainza et al. Nature 2023
Added: 2023-09-20
Proteins that switch conformation
- Switch in response to peptide binding
Praetorius et al. Science 2023
Added: 2023-09-21
Proteins for biological materials
- Yeast secretion technology
Idiris et al. Appl. Microbiol. Biotechnol. 2010
Added: 2023-10-23 - Superstrong silkworm silk
Wang et al. Matter 2022
Added: 2023-10-22 - Spider silk from silkworms
Mi et al. Matter 2023
Added: 2023-10-22 - Shock-absorbing protein gels
Doolan et al. Nat. Nanotechnol. 2023
Research briefing on article
Added: 2023-09-20
Proteins as food (precision fermentation)
- Opportunities and challenges
Youtube video
Added: 2024-01-07
Enzymes for green energy
- Fatty acids to hydrocarbons using light (FAP)
Samire et al. Sci. Adv. 2023
Added: 2023-09-20
Antibodies and binders
- News and views on nanobodies
Voss Nature 2021
Added: 2023-09-20 - Perspective on bispecific antibodies
Brinkmann and Kontermann Science 2021
Added: 2023-09-20 - TCR catch bond engineering
Zhao et al. Science 2022
Added: 2023-09-20
GPCRs
- Review of sensors
Kroning et al. Clin. Transl. Med. 2022
Added: 2023-10-22 - Yeast as platform for human GPCR studies
Wang et al. Biochem. Pharmacol. 2021
Added: 2023-09-20 - Yeast-based directed-evolution of GPCRs
Meltzer et al. Sci. Rep. 2022
Added: 2023-10-23 - Sensor for adhesion GPCR activation
Scholz et al. Nature 2023
Added: 2023-09-20 - Sex and sugar in yeast
Versele et al. EMBO Rep. 2001
Added: 2023-11-19 - GPCR-based yeast biosensor for cannabinoids
Miettinen et al. Nat. Commun. 2022
Added: 2023-11-19
Prions and amyloids
- Review on prions in yeast
Wickner JBC 2019
Added: 2023-09-22 - Ure2-URE3 tagging
Zhao et al. JBC 2018
Added: 2023-09-22
Aging
- Review on brain rejuvenation
Bieri et al. Nat. Neurosci. 2023
Added: 2023-09-22 - PF4 (CXCL4) factor
Schroer et al. Nature 2023
Added: 2023-09-22 - Oscillator to suppress two modes of aging in yeast
Zhou et al. Science 2023
Added: 2023-09-22 - Two types of aging in yeast
Li et al. Science 2020
Added: 2023-09-22
Proteins for logical operations
- Energetics of LOV2 switch
Yao et al. Nat. Chem. Biol. 2008
Added: 2023-10-15 - Unfolding of alpha- and beta-helical domains
DeBenedictis et al. Soft Matter 2019
Added: 2023-10-15 - Mechanical resistance of beta sheets
Brockwell et al. Nat. Struct. Mol. Biol. 2003
Added: 2023-10-15 - LOV2-Src
Dagliyan et al. Science 2016
Added: 2023-10-15 - Video on logic gates built with pulleys
Vimeo
Added: 2023-10-20 - Video on AND gate built with dominos
Youtube
Added: 2023-10-20 - Make logic gates out of anything
Website
Added: 2023-10-23 - Spring network models
Yan et al. PNAS 2017
Yan et al. Biophys. J. 2018
Bravi et al. PLoS Comp. Biol. 2020
Added: 2023-10-26