2024
Solid-phase peptide synthesis in 384-well plates
Journal Of Peptide Science
2024
DOI : 10.1002/psc.3555
Methods for high-throughput synthesis and screening of peptide libraries
Lausanne: EPFL2024
p. 173.DOI : 10.5075/epfl-thesis-10747
Cyclic Peptides for Drug Development
Angewandte Chemie International Edition
2024
Vol. 63 , num. 3.DOI : 10.1002/anie.202308251
2023
Development of cyclic peptides that can be administered orally to inhibit disease targets
Nature Chemical Biology
2023
DOI : 10.1038/s41589-023-01505-0
De novo development of small cyclic peptides that are orally bioavailable
Nature Chemical Biology
2023
DOI : 10.1038/s41589-023-01496-y
High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides
Chembiochem
2023
Vol. 25 , num. 3.DOI : 10.1002/cbic.202300592
Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
Angewandte Chemie-International Edition
2023
Vol. 62 , num. 33, p. e202306036.DOI : 10.1002/anie.202306036
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays
Nature Communications
2023
Vol. 14 , num. 1, p. 2774.DOI : 10.1038/s41467-023-38075-7
Motifs for making tricycles
Nature Chemical Biology
2023
DOI : 10.1038/s41589-023-01329-y
Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds
Lausanne: EPFL2023
p. 242.DOI : 10.5075/epfl-thesis-9951
2022
Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides
Organic & Biomolecular Chemistry
2022
Vol. 20 , num. 29, p. 5699 – 5703.DOI : 10.1039/d2ob00910b
Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications
2022
Vol. 13 , num. 1, p. 3823.DOI : 10.1038/s41467-022-31428-8
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase
Acs Chemical Biology
2022
Vol. 17 , num. 1, p. 181 – 186.DOI : 10.1021/acschembio.1c00843
Generating macrocyclic inhibitors of protein-protein interactions
Lausanne: EPFL2022
p. 189.DOI : 10.5075/epfl-thesis-9431
2021
Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity
Protein Engineering Design & Selection
2021
Vol. 34 , p. gzab018.DOI : 10.1093/protein/gzab018
Towards the Development of Orally Available Peptide Therapeutics
CHIMIA International Journal for Chemistry
2021
Vol. 75 , num. 6, p. 514 – 517.DOI : 10.2533/chimia.2021.514
Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support
Biomaterials
2021
Vol. 272 , p. 120778.DOI : 10.1016/j.biomaterials.2021.120778
Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
Angewandte Chemie-International Edition
2021
Vol. 60 , num. 16, p. 9022 – 9031.DOI : 10.1002/anie.202014511
Methods for the generation of large combinatorial macrocycle libraries
Lausanne: EPFL2021
p. 152.DOI : 10.5075/epfl-thesis-9095
2020
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Nature Communications
2020
Vol. 11 , num. 1, p. 3890.DOI : 10.1038/s41467-020-17648-w
Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science
2020
Vol. 11 , num. 30, p. 7858 – 7863.DOI : 10.1039/D0SC01944E
2019
Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome
Lausanne: EPFL2019
p. 184.DOI : 10.5075/epfl-thesis-7676
Novel Molecular Probes for Non-invasive Optical Imaging of Fatty Acid and Triglyceride Uptake in Living Animals
Lausanne: EPFL2019
p. 151.DOI : 10.5075/epfl-thesis-8437
Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation
Lausanne: EPFL2019
p. 168.DOI : 10.5075/epfl-thesis-7223
2018
Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2
Lausanne: EPFL2018
p. 195.DOI : 10.5075/epfl-thesis-8467
2017
Bypassing bacterial infection in phage display by sequencing DNA released from phage particles
Protein Engineering, Design and Selection
2017
Vol. 30 , num. 11, p. 761 – 768.DOI : 10.1093/protein/gzx057
Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity
Journal Of Medicinal Chemistry
2017
Vol. 60 , num. 3, p. 1151 – 1158.DOI : 10.1021/acs.jmedchem.6b01548
New methods for developing (bi)cyclic peptides by phage display
Lausanne: EPFL2017
p. 158.DOI : 10.5075/epfl-thesis-8092
Development of an albumin-binding ligand for prolonging the plasma half-life of peptide therapeutics
Lausanne: EPFL2017
p. 206.DOI : 10.5075/epfl-thesis-7728
Phage Selection of Cyclic Peptides for Application in Research and Drug Development
Accounts Of Chemical Research
2017
Vol. 50 , num. 8, p. 1866 – 1874.DOI : 10.1021/acs.accounts.7b00184
Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
Nature Communications
2017
Vol. 8 , p. 16092.DOI : 10.1038/ncomms16092
Cyclic peptide therapeutics: past, present and future
Current Opinion In Chemical Biology
2017
Vol. 38 , p. 24 – 29.DOI : 10.1016/j.cbpa.2017.02.006
2016
Development of potent and selective S. aureus sortase A inhibitors Based on Peptide Macrocycles
ACS Medicinal Chemistry Letters
2016
Vol. 7 , num. 6, p. 606 – 611.DOI : 10.1021/acsmedchemlett.6b00045
Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone
Chembiochem
2016
Vol. 17 , num. 24, p. 2299 – 2303.DOI : 10.1002/cbic.201600336
Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling
ChemMedChem
2016
Vol. 11 , num. 8, p. 834 – 839.DOI : 10.1002/cmdc.201500557
Phage selection of chemically stabilized alpha-helical peptide ligands
ACS Chemical Biology
2016
Vol. 11 , num. 5, p. 1422 – 1427.DOI : 10.1021/acschembio.5b00963
2015
Generation of photoswitchable peptide ligands by phage display
Lausanne: EPFL2015
DOI : 10.5075/epfl-thesis-6483
2014
Phage Selection of Photoswitchable Peptide Ligands
Journal Of The American Chemical Society
2014
Vol. 136 , num. 16, p. 5880 – 5883.DOI : 10.1021/ja501861m
Peptide ligands stabilized by small molecules
Angewandte Chemie (International ed. in English)
2014
Vol. 53 , num. 6, p. 1602 – 6.DOI : 10.1002/anie.201309459
Improving Bicyclic Peptide Phage Display and Development of Sortase A Inhibitors
Lausanne: EPFL2014
DOI : 10.5075/epfl-thesis-6413