In this area of research, we seek to identify reactions of significant synthetic importance whose catalytic enantioselective version is currently unknown or only of limited application scope/efficiency. In searching for solutions to these problems, we are not confined to a particular family of catalysis. Instead, we will explore any available toolkits that sounds reasonable on the basis of our working hypothesis and of course, on the basis of serendipities.
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Selected publications:
- Wu, H.; Wang, Q., Zhu, J. “Catalytic Enantioselective Benzilic Ester Rearrangement” Angew. Chem. Int. Ed. 2020, 59, 7261-7265.
- He, Y.-P.; Wu, H.; Wang, Q., Zhu, J. “Palladium-catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles” Angew. Chem. Int. Ed. 2020, 59, 2105-2109.
- Wu, H.; Qang, Q.; Zhu, J. “Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters” J. Am. Chem. Soc. 2019, 141, 11372-11377.
- Zheng, S.-C.; Wang, Q.; Zhu, J. “Catalytic Kinetic Resolution via Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction to Enantioenriched 3-Arylpyrroles” Angew. Chem. Int. Ed. 2019, 58, 9215-9219.
- Zheng, S.-C.; Wang, Q.; Zhu, J. “Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles ” Angew. Chem. Int. Ed. 2019, 58, 1494-1498.
- Wu, H.; Andres, R.; Wang, Q.; Zhu, J. “Catalytic Enantioselective α-Ketol Rearrangement” Angew. Chem. Int. Ed. 2019, 58, 499-503.
- Wu, H.; Wang, Q.; Zhu, J, “Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts” Angew. Chem. Int. Ed. 2018, 57, 2721-2715.
- Bao, X.; Wang, Q.; Zhu, J, “Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (–)-Mesembrane and (+)-Crinane” Angew. Chem. Int. Ed. 2018, 57, 1995-1999.
- Tong S.; Limouni,; Wang, Q.; Wang, M.-X.; Zhu, J. “Catalytic enantioselective reaction with statistical amplification of product enantiopurity” Angew. Chem. Int. Ed. 2017, 56, 14192-14196.
- Kong, W.; Wang, Q.; Zhu, J. “Water as Hydride Source in Palladium-Catalyzed Enantioselective Reductive Heck Reaction” Angew. Chem. Int. Ed. 2017, 56, 3987-3991