2024
September 2024 : Clément is back in the lab to start his PhD ! Good luck with your research !
August 2024 : Rémi and his Ynimines strike again ! Congratulations on his work on “[4+1] Heteroannulation to Form 1-Pyrrolines through Alder-Ene Reaction of in situ Generated Ynimines: Development and Application in Total Synthesis of Borrecapine” published in ACIE.
July 2024 : Congratulations to Hua and Takuji on their work entitled “Quaternary Carbon Editing Enabled by Sequential Palladium Migration” published in JACS !
Mai 2024 : Warm welcome to Dr. Dianpeng Chen, our new postdoctoral researcher !
April 2024 : Congratulations to Tristan and Baochao for their paper entitled “Editing Tetrasubstituted Carbon: Dual C−O Bond Functionalization of Tertiary Alcohols Enabled by Palladium-Based Dyotropic Rearrangement” published in JACS.
March 2024 : Congratulations to Takuji for his paper entitled “Arylative Ring Expansion of 3-Vinylazetidin-3-Ols and 3-Vinyloxetan-3-Ols to Dihydrofurans by Dual Palladium and Acid Catalysis” published in ACIE.
February 2024 : The first joint paper with the group of Professor Jerome Waser “Benzylic C(sp3) H Azidation: Copper vs Iron Catalysis” has been published in Helv. Chim. Acta. This paper is dedicated to Prof. Alois Fürstner, President of th 56th Bürgenstock conference 2023. Congratulations to Angel, Omar and Pierre (Jerome’s lab).
Warm welcome to Clément Rols, our brand new master student and to Dr. Youjie Yu, our new postdoctoral fellow ! Good luck in your research !
2023
December 2023 : Congratulations to Qiang and Chen-xu on their new dyotropic reaction titled : “Palladium-Based Dyotropic Rearrangement Enables A Triple Functionalization of Gem-Disubstituted Alkenes : An Unusual Fluorolactonization Reaction“, published in ACIE !
October 2023 : Congratulations to Rémi for bringing in the first terpene of the lab ! Very nice work on the Enantioselective Total Synthesis of (−)-Artatrovirenol A !
August 2023 : LSPN strikes in the Swiss Summer School Organic Synthesis 2023 ! Congratulations to Takuji on his winner prize for the best poster and Cédric on his runner-up prize for the best short presentation !
July 2023 : Congratulations to Jing on another dyotropic rearrangement published in JACS ! “Diverting the 5-exo-Trig Oxypalladation to Formally 6-endo-Trig Fluorocycloetherification Product through 1,2-O/Pd(IV) Dyotropic Rearrangement”
May 2023 : Another diene difunctionalization, another ACS Catalysis ! Congrats to Dan and Weisi on their work “Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes” !
April 2023 : Warm welcome to our new PhD student Morgane Delattre. Enjoy your time at LSPN ! Welcome to Chenxu Liu, our new post-doctoral researcher !
March 2023 : Congratulations to Qiang on his dyotropic rearrangement entitled “Oxidative rearrangement of 1,1-disubstituted alkenes to ketones” published in Science. Nice achievement !
Congratulations to Rémi L. on another work on ynimines published in Angewandte ! “Terminal Alkynes as One-Carbon Donors in [5+1]Heteroannulation: Synthesis of Pyridines via YnimineIntermediates and Application in the Total Synthesis ofAnibamine”
February 2023 : Welcome to our new PhD exchange student Beatriz Gonzàlez Saiz and our two new Master students Sélène Castanet and Amaël Grégoire !
Congratulations to Rémi for his new paper on the “Divergent Asymmetric Total Synthesis of (-)-Voacafricines A & B” published in Angewandte !
Congratulations to Baochao and Guang on their total synthesis of Stephadiamine ! “Enantioselective Total Synthesis of (+)-Stephadiamine”
January 2023 : Welcome to our new PhD exchange student Sathish Damodharan !
2022
November 2022 : Another Pictet-Spengler reaction strikes ! Congratulations to Rémi and Fenggang for their project entitled “Organocatalytic Enantioselective Pictet-Spengler Reaction of α-Ketoesters: Development and Application to the Total Synthesisof (+)-Alstratine A“, published in Angewandte.
Good job to Xinqi on his work published in Angewandte ! “Organocatalytic Enantioselective Diels-Alder Reaction of 2-Trifluoroacetamido-1,3-dienes with α,β-Unsaturated Ketones”
October 2022 : Congratulations to Jing for his work on dyotropic rearrangements published in Angewandte !“Apparent 6-endo-trig Carbofluorination of Alkenes Enabledby Palladium-Based Dyotropic Rearrangement”
September 2022 : Congrats to Dina, Alberto and Cyril for their publication in Organic Letters ! “Synthesis of 3‑Acyloxyindolenines by TiCl3‑Mediated Reductive Cyclization of 2‑(ortho-Nitroaryl)-Substituted Enol Esters”
Welcome to our new PhD student Paul Gri !
August 2022 : Congratulations to Guoqiang and Hua for their work on “Migrative Carbofluorination of Saturated Amides Enabled by PdBased Dyotropic Rearrangement” published in JACS !
Warm Welcome to our new master student Morgane Delattre in the group !
June 2022 : Congrats to Jia-Chen and Cédric for their paper published Nature Communications ! “Taming the radical cation intermediate enabled one-step access to structurally diverse lignans”
May 2022 : Congratulations to Takuji for his work published in JACS, titled “Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes”. Good job !
March 2022 : Another Pictet-Spengler for big Rémi ! Good job on your new Angewandte paper : “Catalytic Enantioselective Pictet–Spengler Reaction of a–Ketoamides Catalyzed by a Single H–Bond Donor Organocatalyst”.
January 2022 : Good job to Alex on his paper on “Two-Carbon Ring Expansion of Cyclobutanols to Cyclohexenones Enabled by Indole Radical Cation Intermediate: Development and Application to a Total Synthesis of Uleine“. Nice achievment !
2021
December 2021 : Welcome to our new post-doc Ruijia Wang !
November 2021 : Welcome to our new visiting PhD student Xin He ! Enjoy your stay in Switzerland !
October 2021 : Welcome to our new PhD student Vincent Goëlo. Good luck on your research !
September 2021 : Welcome to our new post-doctoral researcher Xinqi Zhu !
Small Rémi strikes ! Nice work on “Copper‐Catalyzed Aza‐Sonogashira Cross‐Coupling to Ynimines: Development and Application to the Synthesis of Heterocycles” !
August 2021 : Congrats to Dan for his publication in ACS Catalysis ! “Photoredox Catalytic Three-Component Amidoazidation of 1,3-Dienes”
July 2021 : Another set of natural products for Bastien ! “Enantioselective Total Synthesis of (+)-Nordasycarpidone, (+)-Dasycarpidone, and (+)-Uleine”
June 2021 : Welcome to our new post-doc Qiang Feng !
May 2021 : Welcome to our new post-doc Fenggang Sun and good job to Hua and Yu-Ping on their JACS paper ! “Catalytic Enantioselective Synthesis of Morpholinones Enabled by Aza-Benzilic Ester Rearrangement”
Weisi’s review called “Visible light photoredox-catalysed remote C-H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT)” is now online. Good job !
Jian And Hua work on “C-C bond activation enabled by dyotropic rearrangement of Pd(iv) species” has been accepted in Nature Chem. ! Great job !
April 2021 : Welcome to our new post-doc Baochao Yang and congratulations to Alex on his article published in Chimia ! “Iron-Catalysed Remote C(sp3)-H Azidation of O-Acyl Oximes and N -Acyloxy Imidates”
Congrats to Bastien on his Outlook on the use of 1,2 rearrangements in total synthesis ! “Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step”
Congratulations to Guang, Nico and Cyril for their paper just accepted in Angewandte Chemie-International Edition ! ” Enantioselective Total Synthesis of (+)-Alstilobanine C, (+)-Undulifoline, and (-)-Alpneumine H”
February 2021 : Congrats to Weisi for his paper “Selective 1,2-Aminoisothiocyanation of 1,3-Dienes Under Visible-Light Photoredox Catalysis” in Angewandte Chemie-International Edition !
January 2021 : Well done to Guang for his paper accepted in Nature Comm. ! “Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids”
2020
December 2020 : Congrats to Yu-ping, Jian and Hua for their work just accepted in Angewandte Chemie-International Edition ! “Catalytic Enantioselective Aminopalladation–Heck Cascade“. Nice job !
November 2020 : Welcome to our new PhD student Dan Forster and our new post-doc Jing Gong !
October 2020 : Warm welcome to our new post-doc Guoqiang Yang. Good luck with your research !
September 2020 : Congratulations to Angel, Omar and Rocio on their work : “Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones” published in Organic Letters and to Jia-Chen on his paper : “Radical-Cation Cascade to Aryltetralin Cyclic Ether Lignans Under Visible-Light Photoredox Catalysis” published in Angewandte Chemie-International Edition !
September 2020 : Warm welcome Cédric Fung and Takuji Fuji, our two new PhD students !
August 2020 : A round of applaus to big Rémi on his total synthesis of Arborisidine published in JACS : “Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction”
June 2020 : Congratulationsto Bastien, Cyril on their work : “TiCl3-Mediated Synthesis of 2,3,3-Trisubstituted Indolenines: Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (-)-Tubifoline“, published in Angewandte Chemie-International Edition. Well done !
June 2020 : Bo’s paper was published in Helv. Chim. Acta in a special issue dedicated to EPFL professor Michael Graetzel : “Synthesis of Benzo[a]carbazoles via Visible Light‐Induced Cycloaromatization”
May 2020 : Congratulations to Tu & Weisi for their communication in Advanced Synthesis & Catalysis : “Copper‐Catalyzed Cyanoalkylative Aziridination of N‐Sulfonyl Allylamines“. This paper is part of a special issue dedicated to Prof. Bernd Giese at the occasion of his 80th birthday.
May 2020 : The lab is gradually re-opening.
April 2020 : Lab lockdown is not a fatality for LSPN Seminars ! Today, Dina gave a talk about “1,4-palladium shifts” – Thank you !
February 2020 : Hua’s investigations on Catalytic Enantioselective Benzilic Ester Rearrangement has been accepted in ACIE. Congratulations !
February 2020 : Dylan’s work towards Sarpagine has been published in Chem. Eur. J : “Towards Sarpagine‐Ajmaline‐Macroline Family Indole Alkaloids: Enantioselective Synthesis of N‐Demethyl Alstolactone Diastereomer” Good Job !
January 2020 : Omar and Zhaodong’s paper was published in Nature Communications “Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes” Congratulations !
January 2020 : Congratulations to former members Guihua & Jian for their recent publications in Organic Letters : “Desymmetrization of Prochiral Cyclopentenes Enabled by Enantioselective Palladium-Catalyzed Oxidative Heck Reaction”
2019
November 2019 : Congratulations to Yu-Ping & Hua for their recent publication in Angewandte “Palladium‐catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3‐Disubstituted Indoles” !
October 2019 : Warm welcome to our new visiting scholar, Dr. Weisi Guo. Enjoy your stay in Switzerland !
October 2019 : Raphael successfully defended his thesis in front of a committee of experts. Congratulations ! Many thanks to Prof. Andreas Kirschning and Bastien Nay for being part of the Jury !
September 2019 : Tonight we celebrate Cyril’s and Omar’s departure ! We wish you all the best for your future careers, and thank you for the pizzas 😉
September 2019 : Welcome to Rémi Laverne, our new PhD student ! Best of luck for your research !
August 2019 : Balazs Budai is the recipient of the Swiss Chemical Society Best Poster Award at the occasion of Villars’ SCS Summer School. Congratulations !
July 2019 : Xu’s most recent work was published in Chem. Eur. J. : “Remote C(sp3)−H Arylation and Vinylation of N‐Alkoxypyridinium Salts to δ‐Aryl and δ‐Vinyl Alcohols“. Xu accepted an academic position in China ; Best of luck for your future career !
July 2019 : Hua’s paper is now online in JACS : “Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters“. Congratulations !
July 2019 : Cyril is the recipient of the 2019 EPFL Doctorate Award ! Congratulations !
April 2019 : Congratulations to Omar & Alex for their recent publication “Iron‐Catalyzed Remote C(sp3)‐H Azidation of O‐Acyl Oximes and N‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols” !
April 2019 : Welcome to our new intern Baptiste Roure !
February 2019 : Xu’s new paper on “Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides” has just been published in Nature Communications ! Congratulations !
February 2019 : Warm welcome to our new intern Dan Forster ! Best of luck with your chemistry !
February 2019 : Hua’s review on catalytic enantioselective rearrangements has been highlighted as a very important paper in Eur. JOC ! Congratulations !
January 2019 : Congratulations to Jacobus & Xu for their new publication in Helvetica Chimica Acta : “Formal[4+1] Cycloaddition of o-Aminobenzyl Chlorideswith Isocyanides: Synthesis of 2-Amino-3-Substituted Indoles”
January 2019 : Congratulations to Xu for his recent publication in Angewandte : “Dual Photoredox/Copper Catalysis for the Remote C(sp3)−H Functionalization of Alcohols and Alkyl Halides by N‐Alkoxypyridinium Salts”
January 2019 : Congratulations to Guang & Cyril for their recent publication in Angewandte : “Stereoselective Total Synthesis of Eburnane-type Alkaloids Enabled byConformation-Directed Cyclization and Rearrangement”
2018
December 2018 : Congratulations to Mathias for receiving the “Teaching Excellence Award” in recognition of his contribution to the education.
December 2018 : Congratulations to Qiu, Charlotte, David and Sheng-Cai for their recent paper in Tetrahedron : “From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of allyl carbonate by α-isocyanoacetate”
December 2018 : Congratulations to Sheng-Cai whose paper was accepted in Angewandte “Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles” !
November 2018 : Congratulation to Nicolas Gaeng for the successful defense of his PhD thesis.
November 2018 : Congratulations to Hua & Rémi for their publication in Angewandte “Catalytic Enantioselective α‐Ketol Rearrangement” !
October 2018 : Welcome to Dina & Rémi, our new PhD students ! Best of luck with your new projects !
September 2018 : Congratulations to Xu, Takayuki and Tu for their recent publication in Nature Communications “Copper-catalyzed methylative difunctionalization of alkenes” !!
September 2018 : Zhaodong’s paper entitled “Copper-Catalyzed Remote C(sp3)-H Arylation of Carboxamides and Sulfonamides” was accepted in Angew Chem. Congratulations!
September 2018 : Zhengren’s review entitled: “Metamorphosis of Cycloalkenes for the Divergent Total Synthesis of Polycyclic Indole Alkaloids” was accepted in Chem. Soc. Rev. Congratulations!
August 2018 : GoodBye to Angel, who stayed one year with us as a PhD Exchange ; he will now return to Mexico to complete his PhD. Good luck !
July 2018 : Welcome to Prof. Zhang Fengzhi, new visiting professor in our group ! Enjoy your stay in Switzerland.
July 2018 : Welcome to Nicoleta, our new summer intern !
July 2018 : Jieping’s and Wangqing’s minireview on the “Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions” is now online on Angewandte.
June 2018 : Shuo’s paper entitled “Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines” was accepted in Tetrahedron. It will be published in a special issue dedicated to the memory of Prof. Sir. Derek H. Barton. Congratulations !
June 2018 : Omar’s paper entitled “Total Synthesis of (+)-Hinckdentine A” was highlighted in Synfacts. Congratulations!
May 2018 : Welcome to Junpei, our new PhD exchange student coming straight from Japan ! Best of luck with your total synthesis !
May 2018 : Qian’s and Jieping’s review on enantioselective MCRs was just published in Accounts of Chemical Research.
April 2018 : Omar’s total synthesis of (+)-Hinckdentine A was just published in Angewandte. Congratulations !
April 2018 : Congratulations to Cyril, who successfully defended his PhD thesis in front of jury professors N. Cramer, J. Waser, E. M. Carreira and A. Furstner ! He will now join the Jacobsen Lab for his postdoctoral research. We all wish you the best of luck and every success for your future research !
March 2018 : Welcome to Rémi, our new master student !
February 2018 : Warmest welcome to our three new interns : Clémence, Léa and Cédric.
January 2018 : Hua’s paper on Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts was accepeted in Angewandte. Congratulations !
January 2018 : Xu’s paper on Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (-)-Mesembrane and (+)-Crinane was accepeted in Angewandte. Congratulations!!
2017
December 2017: Antonin’s paper on Cooperative Pd/Cu Catalysis: Multicomponent Synthesis of Tetrasubstituted Imidazolones from Methyl α-Isocyanoacetates, Primary Amines, and Aryl(vinyl) Iodides was accepted in Organic Letters. Congratulations !
October 2017: Cyril won the Albert Hofmann PhD Award for excellence in research. He will present his work at the Hofmann Symposium in Zurich. Congratulations !
October 2017: Welcome to our new PhD student Alexandre Leclair and our new postdoc Jian Cao.
October 2017: Congratulation to Antonin and Dylan who both defended successfully their PhD! Good luck for your future.
October 2017: Welcome to Bastien Delayre our new PhD and Zhaodong Li our new postdoc.
September 2017: Welcome to our new member Dr. Guihua Chen and Dr. Yuping He!
September 2017: Shuo’s and Aurore’s paper on Catalytic Enantioselective Carbopalladation/C-H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach was accepted in Angewandte. Congratulations!!
September 2017: Xu’s paper on Palladium-Catalyzed Enantioselective Narasaka-Heck/Direct C-H Alkylation of Arene: Iminoarylation of Alkene was highlighted in Synfacts. Congrats!
September 2017: Angel Renteria Gomez joined our group as an exchange PhD student from Mexico. Welcome!
August 2017: Charlotte, our intern, finished her internship. Take some rest before your PhD! Good luck for your future.
August 2017: Cyril received the Best Oral Presentation Prize at the Swiss Summer School 2017-Trends in Organic Synthesis in Villars. Good job!.
August 2017: Antonin’s paper on Silver Nitrate-Catalyzed Isocyanide Insertion/Lactamization Sequence to Imidazolones and Quinazolin-4-ones: Development and Application in Natural Product Synthesis was accepted in Org. Lett. Congratulations!!
August 2017: Cyril received the runner-up prize for the Best Oral Presentation in Organic Chemistry at the SCS Fall Meeting 2017 in Bern. Well done.
<strong”>August 2017: Alex finished his Master project and went back to France. He will start soon a PhD in our group. See you very soon Alex!
July 2017: Hua’s paper on Copper-Catalyzed Enantioselective Domino Arylation/Semipinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts was accepted in Chem. Eur. J. Congratulation
July 2017: Mathias’ paper on Alpha-Oxo-Ketenimines from Isocyanides and Alpha-Haloketones: Synthesis and Divergent Reactivity was accepted in Chem. Eur. J. Congratulation!
July 2017: Welcome to Thomas and Romain our two new interns.
July 2017: Shuo’s paper on Fluorophores for Excited-State Intramolecular Proton Transfer by an Yttrium Triflate-Catalyzed Reaction of Isocyanides with Thiocarboxylic Acids made the cover in Angewandte. Congratulation!
July 2017: Jieping’s review on “To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis” made the cover in Chem. Soc. Rev. Congratulation!
June 2017: Ala’s and Tu’s paper on Copper-Catalyzed Three-Component Carboazidation of Alkenes with Acetonitrile and Sodium Azide was accepted in Angewandte. Congratulation!
April 2017: Hua’s paper on Organocatalytic Enantioselective Acyloin Rearrangement of α-Hydroxy Acetals to α-Alkoxy Ketones was accepted in Angewandte. Congratulation!
March 2017: Wangqing’s paper on Water as a Hydride Source in Palladium-Catalyzed Enantioselective Reductive Heck Reactions was accepted in Angewandte. Congratulation!
2016
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December 2016: All the LSPN members wish you a Merry Christmas and a Happy New Year 2017! 2016 was the end of Tu’s PhD studies. After his master project, Balàzs started his PhD this year and will try to do his best during the following 4 years. Dr Ren and Dr. Wang left the lab for Canada and Dr. Shuo Tong started another post-doc in the LSPN. Welcome back! In addition to the PhDs and post-Docs, many students and interns also spend some weeks/months in the lab and are now hopefully well trained for their future career in chemistry. Concerning the chemistry, this year was full of success with more than 17 papers accepted or already published, most of them in Angewandte Chemie or JACS! 3 recent alkaloids total syntheses were highlighted in Synfact. Tu obtained the SNF scholarship for his future post-doc and Prof. Zhu received the Natural Product Award 2016 from the RSC. 2017 will be a year with many changes with a new lab and at least 6 new master/PhD and post.doc arriving at the beginning of the year. Let’s hope that more papers, more prices and degrees, and more total syntheses will be part of 2017! |
| December 2016: Guanyinsheng’s paper on Palladium-Catalyzed Three-Component Reaction of Propargyl Carbonates, Isocyanides, and Alcohols or Water: Switchable Synthesis of Pyrroles and Its Bicyclic Analogues was accepted in OL. Congratulation! |
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| December 2016: Tu successfully defended his PhD. Congratulation! |
| November 2016: Hua’s paper on Organocatalytic Enantioselective Vinylogous Pinacol Rearrangement Enabled by Chiral Ion Pairing was accepted in ACIE. Congratulation! |
| November 2016: Mathias’ and Guanyinsheng’s paper on Ketenimines from Isocyanides and Allyl Carbonates: Palladium-Catalyzed Synthesis of β,γ-Unsaturated Amides and Tetrazoles was accepted in ACIE. Congratulation! |
| November 2016: Antonin’s paper on Enantioselective Synthesis of Quaternary α-Amino Acids Enabled by the Versatility of the Phenylselenonyl Group was accepted in ChemEurJ. Congratulation! |
| October 2016: Cyril’s paper on Enantioselective Synthesis of (+)-Peganumine A was highlighted in Synfacts as the Synfact of the month. Congratulations! |
| September 2016: Shuo started another post-doc in our group. Welcome back! |
| August 2016: Cyril’s paper on Enantioselective Synthesis of (+)-Peganumine A was accepted in JACS. Congratulation! |
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| August 2016: Tu’s paper on Copper-catalysed cyanoalkylative cycloetherification of alkenes to 1,3-dihydroisobenzofurans: development and application to the synthesis of citalopram was accepted in Chem. Commun.. Congratulation! |
| July 2016: Yang’s paper on Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates was highlighted in Synfacts. Congratulations! |
| July 2016: Manon’s internship in our laboratory is over. Good luck for the future. |
| June 2016: Cyril’s paper on Enantioselective Total Synthesis of (−)-Terengganensine A was highlighted in Synfacts. Congratulations! |
| June 2016: Wangqing’s paper on Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient σ-Alkylpalladium(II) Complex was accepted in ACIE. Congratulation! |
| June 2016: Tu’s and Claire’s paper on Copper-Catalyzed Formal [2+2+1] Heteroannulation of Alkenes, Alkylnitriles, and Water: Method Development and Application to a Total Synthesis of (±)-Sacidumlignan D was accepted in ACIE. Congratulation! |
| June 2016: Welcome to our new PhD student Balázs Budai. Good luck! |
| May 2016: Jieping recieved the Natural Product Award 2016 from the RSC! |
| May 2016: Shuo’s paper on Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence was accepted in ChemEurJ. Congratulation! |
| May 2016: Yang’s paper on Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates was accepted in ChemEurJ. Congratulation! |
| April 2016: Cyril’s paper on Enantioselective Total Synthesis of (−)-Terengganensine A was accepted in ACIE. Congratulation! |
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| April 2016: Welcome to our new Master student Manon Labedan who started a 4 months stay in our lab. At the same time Dr. Weiwu Ren and Dr. Yang Wang left the lab at the end of their post-doc. Good luck for your future! |
| April 2016: Congratulation to Balazs and Johan who successfully defended their Master project. Good luck for the future. |
| March 2016: Martina’s paper on Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile was accepted in OL. Congratulation! |
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| March 2016: Welcome to our new master student Natalie Lamiri. Good luck to our exchange PhD student Takayuki Yokoe who went back to Japan! |
| February 2016: Zhengren’s and Xu’s paper on the Total Synthesis of (-)-Isoschizogamine and Kong’s paper on the Asymmetric Domino Heck/Intermolecular C-H Bond Functionalization were highlighted in Synfacts. Congratulations! |
| February 2016: Weiwu’s paper on Total Synthesis of (±)-Strictamine was accepted in ACIE. Congratulation! |
| January 2016: Thomas’ and Delphine’s paper on Synthesis of Oxazolidin-2-ones by Oxidative Coupling of Isonitriles, Phenyl Vinyl Selenone, and Water was accepted in ChemEurJ. Congratulation! |
2015
| December 2015: All the LSPN members wish you a Merry Christmas and a happy new year 2016!
2015 was the end of their studies for some PhD students of the LSPN, namely Olivier, Viktoria and Claire. Mathias, Raphaël and Aurore started their PhD this year and will try to do their best during the following 4 years. Dr. Tong and Dr. Guanyinsheng left the lab for new opportunities but Dr. Torres Ochoa and Dr. Wu replaced them and started a post-doc in the LSPN. In addition to the PhD and post-Doc, many students and interns also spend some weeks/months in the lab and are now hopefully well trained for their future career in chemistry. Concerning the chemistry, this year was full of success with more than 12 papers accepted or already published in the top journals. Some of our group members won prices for their work in the LSPN and obtained scholarship Let’s hope that more papers, more prices and degrees, and more total syntheses will be part of 2016! |
| December 2015: Wangqing’s paper on Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole was accepted in JACS. Congratulation! |
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| December 2015: The LSPN Christmas dinner took place at Jieping’s house with plenty of delicious Chinese food and wine. What a great night! |
| December 2015: Viktoria successfully defended her PhD. Congratulations! |
| November 2015: Welcome to our new exchange PhD student Takayuki Yokoe! |
| November 2015: Welcome to our new PhD student Aurore Limouni! |
| October 2015: Tu’s and Bo’s paper on Sulfonamide and Tertiary Amine as Nucleophiles in Pd(II)-Catalyzed Diamination of Alkynes: Synthesis of Tetracyclic Indolobenzothiazine S,S-Dioxides was accepted in OL. Congratulation! |
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| October 2015: Dylan’s and Zhengren’s paper on Enantioselective Total Syntheses of (−)-Rhazinilam, (−)-Leucomidine B, and (+)-Leuconodine F was accepted in ACIE. Congratulation! |
| October 2015: Zhengren’s and Xu’s paper on An Enantioselective Total Synthesis of (−)-Isoschizogamine was accepted in ACIE. Congratulation! |
| October 2015: LSPN group outing was hold at Parc Aventure in Signal-de-Bougy followed by a “Crêpes Party” in the lab. A lot of fun!!! |
| October 2015: Welcome to our new PhD student Raphaël Beltran and to our new post-doc Ruben Omar Torres Ochoa! |
| September 2015: A small party was organized for the 50 years old of Prof. Jieping Zhu with all the current group members, some former members and his friends. Thanks to all the people who participated to this surprise party! |
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| September 2015: Cyril won the Runner’s Up Prize for the Best Oral Presentation in the Organic Chemistry section at the Swiss Chemical Society Fall Meeting. Congratulations! |
| September 2015: Welcome to our new Post-Doc Wu Hua! |
| August 2015: Shuo’s, Zhengren’s and Mathias’ paper on Aqueous Titanium Trichloride-Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine was accepted in ACIE. Congratulation! |
| August 2015: Group Seminars (Exercises and presentations) are now available on our website under the “Group pages” section! |
| July 2015: David successfully defended his Master thesis. At the same time, Balazs and Johan finished their semester project and Nikita his internship. Good luck to all of you for your future. |
| July 2015: Having successfully defended his PhD Olivier will leave the LSPN for Bristol where he will do a post-doc in the Aggarwal group. |
| June 2015: Olivier successfully defended his PhD on the 03.06.2015! Congratulations! |
| May 2015: Welcome to Nikita Kavokinewho who will spend 2 months in our group for an internship. |
| May 2015: Zhengren’s paper on Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C was accepted in JACS Congratulation! |
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| May 2015: Prof. Zhu and Dr. Wang have published a new book chapter called “Multicomponent Domino Process: Rational Design and Serendipity” in “Domino Reactions”. You can buy it now online (available in hard copy, pdf and for your mobile device). |
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| May 2015: Prof. Zhu and Dr. Wang have published a new book chapter called “Other Heterocycles” in “Stereoselective Multiple Bond-forming Transformations in Organic Synthesis”. You can buy it now online (available in hard copy, pdf and for your mobile device). |
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| May 2015: Dr. Shuo Tong left the lab at the end of her post-doc. Good luck for your future! |
| May 2015: Welcome to our new PhD student Mathias Mamboury from EPFL. Good luck for your PhD! |
| April 2015: Shuo’s paper on Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts was highlighted in Synfacts. Congratulations! |
| April 2015: Ala’s paper on Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles was accepted in OL. Congratulation! |
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| March 2015: Bo’s paper on Pd/C-Catalyzed Cyclizative Cross-Coupling of Two ortho-Alkynylanilines under Aerobic Conditions: Synthesis of 2,3′-Bisindoles was accepted in Chem. Eur. J. Congratulation! |
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| March 2015: Welcome to our new Master student from Netherlands Jacobus Jong. |
| March 2015: Our exchange PhD student Martina Spallarossa went back to Italy to finish her PhD. Good luck for the future. |
| March 2015: Tu’s and Bo’s paper on 2-(Methoxycarbonyl)ethyl as a Removable N-Protecting Group: Synthesis of Indoloisoquinolinones by Pd(II)-Catalyzed Intramolecular Diamination of Alkynes was accepted in OL. Congratulation! |
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| March 2015: Claire’s paper on Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols was accepted in ACIE. Congratulation! |
| February 2015: Welcome to our new master student David Savary who will perform his Master project in our lab. Good luck! |
| February 2015: Congratulation to our student Raphaël De Matos who successfully defended his Master Thesis. Good luck for the future. |
| February 2015: Welcome to our new master students Balazs Budai and Johan Sulmoni who will perform a semester project in our lab. Good luck! |
| January 2015: Ala’s paper on Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center was accepted in ACIE. Congratulation! |
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January 2015: Our lab has published a new book about Multicomponent Reactions in Organic Synthesis with the help of Wiley-VCH. You can buy it now online (available in hard copy, pdf and for your mobile device). “Comprehensive and up-to-date, this book focuses on the latest advances, such as recent techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. Edited by leading experts and authored by the “who’s who” in multicomponent reaction chemistry.” |
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2014
| December 2014: The LSPN and all its members wish you a Merry Christmas and a very successful year 2015!
This year was full of successful chemistry with more than 10 papers accepted or already published in the top journals. Moreover many of our group members won prices for their work in the LSPN. 2014 was also the end of their studies for the first PhD students of the LSPN, namely Ala, JB and Thomas. Nicolas and Cyril started their PhD this year and will try to do at least as good as the “old” PhD. Dr. Xu and Dr. Bo left the lab for new opportunities but Dr. Wangqing, Dr. Xu and Dr. Guanyinsheng replaced them and started a post-doc in the LSPN. Let’s hope that more papers, more prices and degrees, and more total syntheses will be part of 2015! |
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| December 2014: Ala’s and Tiffany’s paper on Pd-Catalyzed Dehydrogenative Aryl–Aryl Bond Formation via Double C(sp2)–H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles was accepted in OL. Congratulation! | |
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December 2014: Having successfully defended their PhD Ala, Thomas and JB will leave the LSPN.
In the same time Dr. Yao Bo got a position in Beijing Institute of Technology and will also leave the LSPN. Good luck to all of you for the future! |
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| December 2014: The whole LSPN group celebrated the end of the year by organizing a party with some hot wine as apero, some good cheese and white wine for the meal and some amazing meringues for the desert. Photos are online! | |
| November 2014: Shuo’s paper on Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts was accepted in ACIE. Congratulation | |
| November 2014: JB successfully defended his PhD on the 12.11.2014! Congratulations! | |
| October 2014: Thomas successfully defended his PhD on the 23.10.2014! Congratulations! | |
| October 2014: JB’s paper on Phosphoric Acid Catalyzed Desymmetrization of Bicyclic Bislactones was highlighted in Synfacts. Congratulations! | |
| October 2014: Welcome to our new PhD student Nicolas Gaeng from EPFL. Good luck for your PhD! | |
| October 2014: Ala successfully defended her PhD on the 09.10.2014! She is the first student to obtain her PhD of the LSPN in EPFL! Congratulations! | |
| October 2014: Ala’s paper on Copper-Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles was accepted in ChemEurJ. Congratulations! | |
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| October 2014: Cyril won the BASF Best Master Thesis in Molecular and Biological Chemistry Award for his master project. Congratulations! | |
| October 2014: Olivier’s paper on Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of Goniomitine, 1,2-Dehydrospermidine, Aspidospermidine, Vincadifformine and Kopsihainanine A was accepted in JACS. Congratulations! | |
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| October 2014: Welcome to our two new post-docs Dr. Wanqing Kong from Switzerland and Dr. Guanyinsheng Qiu from China. | |
| October 2014: Our exchange PhD student Claire Chatalova went back to Vancouver to finish her PhD. Good luck. We will miss you! | |
| September 2014: Our Post-Doc Zhengren Xu left Switzerland for another post-doctoral position in Florida. Good luck Dr. Xu. Hope to see you soon… | |
| September 2014: Thomas won the Best Poster Award and Olivier won the second price for the Best Oral Presentation Award at the Swiss Chemical Society Fall Meeting in Zürich. Congratulations!!! | |
| September 2014: Welcome to our new Master student Raphaël De Matos who will spend 4 months in our group for his Master Project. | |
| September 2014: The Waser’s, the Cramer’s and our group went for our group outing in Payerne for some karting followed by a nice BBQ in front of our building. Photos are online! | |
September 2014: Welcome to our two new lab members:
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| August 2014: Bo’s paper on Mechanistic Study on the Palladium(II)-Catalyzed Synthesis of 2,3-Disubstituted Indoles Under Aerobic Conditions: Anion Effects and the Development of a Low-Catalyst-Loading Process was accepted in Chem. Eur. J. Congratulations! | |
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| August 2014: Thomas’ paper on Triple Role of Phenylselenonyl Group Enabled a One-Pot Synthesis of 1,3-Oxazinan-2-ones From α-Isocyanoacetates, Phenyl Vinyl Selenones, and Water was accepted in JACS. Congratulations! | |
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| July 2014: JB’s paper on Phosphoric Acid Catalyzed Desymmetrization of Bicyclic Bislactones Bearing an All-Carbon Stereogenic Center: Total Syntheses of (−)-Rhazinilam and (−)-Leucomidine B was accepted in ACIE. Congratulations! | |
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| June 2014: Welcome to Mathias Mamboury who joined us for a 3 months internship! | |
| Mai 2014: Thomas’ paper on From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone was accepted in Chimia. Congratulations! | |
| April 2014: Giulia’s paper on Copper-catalyzed three-component synthesis of 5-acetamidoimidazoles from carbodiimides, acyl chlorides and isocyanides was accepted in Org. Chem. Front. Congratulations! | |
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| April 2014: Weiwu’s paper on Total Synthesis of (±)-Aspidophylline A was highlighted in Synfacts. Congratulations! | |
| March 2014: Ala’s paper on Three-Component Povarov Reaction–Heteroannulation with Arynes: Synthesis of 5,6-Dihydroindolo[1,2-a]quinolines was accepted in OL. Congratulations! | |
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| March 2014: Weiwu’s paper on Total Synthesis of (±)-Aspidophylline A was highlighted in ACIE. Congratulations! | |
| March 2014: Welcome to our new lab apprentice Corentin. | |
| March 2014: Shun and Cyril successfully defended their Master Thesis! Congratulation to both of you and good luck for the future! Cyril will directly start his PhD in our group. | |
| February 2014: Zhengren’s paper on Enantioselective Total Syntheses of Leuconolam–Leuconoxine–Mersicarpine Group Monoterpene Indole Alkaloids was highlighted in Synfacts. Congratulations! | |
| February 2014: Welcome to our new Master student Raphaël De Matos Jovia! | |
| February 2014: Weiwu’s paper on Total Synthesis of (±)-Aspidophylline A made the cover of ACIE. Congratulations to Weiwu and Thomas for the design. | |
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| February 2014: Weiwu’s paper on Total Synthesis of (±)-Aspidophylline A was accepted in ACIE. Congratulations! and made the Cover. Congratulations! | |
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2013
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| December 2012: Congratulations to Ioulia for successfully defending her PhD. thesis. | |||||||||||||||||||||||||||||||||||||||
| November 2012: Ala’s paper on Synthesis of Indoles by Copper-Catalyzed Heteroannulation has been accepted to Synthesis. Congratulations Ala! | |||||||||||||||||||||||||||||||||||||||
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| November 2012: Bo’s paper on Palladium-Catalyzed Coupling of ortho-Alkynylanilines with Terminal Alkynes Under Aerobic Conditions has been accepted to Angewandte Chemie. Congratulations Bo! | |||||||||||||||||||||||||||||||||||||||
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| October 2012: Tiffany’s paper on Palladium-Catalyzed Domino Carbopalladation/C(sp3)-C(sp3) Bond-Forming Process has been accepted to Angewandte Chemie. Congratulations Tiff! | |||||||||||||||||||||||||||||||||||||||
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| September 2012: JB’s paper on Amidation of Aldehydes and Alcohols through α-Iminonitriles has been accepted to Chemistry, An European Journal. Congratulations Jean-Bat! | |||||||||||||||||||||||||||||||||||||||
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| August 2012: Welcome to our new Post-doc Weiwu! | |||||||||||||||||||||||||||||||||||||||
| June 2012: Tiffany’s paper on Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions has been accepted to Organic Letters. Congratulations Tiffany! | |||||||||||||||||||||||||||||||||||||||
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| June 2012: Welcome to our new PhD student Minh Tu! | |||||||||||||||||||||||||||||||||||||||
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June 2012: Thomas OL on Total Synthesis of Trigonoliimine B was highlighted in Synfacts Congratulations Thomas! |
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| April 2012: Check out the new group website! | |||||||||||||||||||||||||||||||||||||||
| April 2012: Bo’s paper on Pd(II)-Catalyzed Intramolecular Diamination of Alkynes has been accepted to Angewandte Chemie. Congratulations Bo!!! | |||||||||||||||||||||||||||||||||||||||
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| March 2012: Bo’s paper on Synergistic Effect of Palladium and Copper Catalysts has been accepted to Chemistry- A European Journal. Go Bo go!!! | |||||||||||||||||||||||||||||||||||||||
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| January 2012: Thomas’ paper on Total Synthesis of Trigonoliimine B has been accepted to Organic Letters. Congratulations Thomas! | |||||||||||||||||||||||||||||||||||||||
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