Category: line1
Trio preserves motor ability during aging
Is the weakening of motor ability with age inevitable? In a new study we show that motor neuron synapse levels of the conserved Rac GEF protein Trio reduce with age in Drosophila. Increasing Trio expression during aging (including by expression of transgenic human Trio) preserves the structure of motor synapses during aging, improving their function (…)
Protein ‘traffic jam’ linked to neurodegeneration
The Cruelest Cut: EPFL article about our new paper, led by Jamshid, which shows that Retromer deficiency, which is implicated in both Parkinson’s and Alzheimer’s Disease, increases human Tau truncation and toxicity. In the paper we also describe new tools to quantitate neurodegeneration with single synapse or axon resolution in intact Drosophila brains.
Welcome New Lab Members
Welcome to new lab members Medha, Amin and Rebecca. Delighted to have you join us and work on projects in synaptic plasticity, miniature neurotransmission and neurotransmitter logic.