Category: line4
Minis maintain synapses
Exciting new publication from the lab on miniature neurotransmission and ageing led by Soumya. In the paper we describe a new adult Drosophila motor synaptic terminal NMJ preparation, genetic tools and electrophysiology methods. We use the prep to examine the effects of ageing on motor synapses. We find that synaptic terminal boutons fragment into smaller (…)
New Review by Emma
Graduate student Emma Källstig has published a new review on the links between the NF-κB pathway and the motor neuron disease ALS. Read it here.
Predictive Power
A new publication with our clinical collaborators at Columbia University Medical Center in New York reveals sensory-motor circuit dysfunction in human Spinal Muscular Atrophy (SMA) patients as was predicted by our Drosophila model of SMA. Unfortunately 4-AP treatment, which we found was efficacious in models to correct sensory-motor deficits, at lower levels does not seem (…)