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Apply by April 15 for PhD position
Apply to now for an open PhD position working on motor neuroscience in our laboratory. We investigate motor system synapse and circuit function in #Drosophila and apply our models to understand human motor system dysfunction during ageing and in the disorders #ALS, #FTD and #SMA.https://www.epfl.ch/labs/mccabelab/positions/[image or embed]— McCabe Lab (@mccabelab.org) March 13, 2025 at 10:14 (…)
Thank you Target ALS
Thank you to Target ALS for highlighting the work on #ALS in our laboratory together with Bernard Schneider and Sabine Liebscher. We are very grateful for your funding and unflagging support – www.targetals.org/2025/03/04/i…[image or embed]— McCabe Lab (@mccabelab.org) March 5, 2025 at 2:59 PM
Medha wins EPFL MT180
Many congratulations to lab member Medha Raman for winning the EPFL final of MT180 – My Thesis in 180 seconds[image or embed]— McCabe Lab (@mccabelab.org) March 30, 2025 at 5:36 PM
Selected Older News
Combating Age-Related Motor Decline
Many thanks to The Scientist for covering our work on delaying motor decline during aging – https://www.the-scientist.com/combating-age-related-motor-decline-72095
Trio preserves motor ability during aging
Is the weakening of motor ability with age inevitable? In a new study we show that motor neuron synapse levels of the conserved Rac GEF protein Trio reduce with age in Drosophila. Increasing Trio expression during aging (including by expression of transgenic human Trio) preserves the structure of motor synapses during aging, improving their function (…)
Protein ‘traffic jam’ linked to neurodegeneration
The Cruelest Cut: EPFL article about our new paper, led by Jamshid, which shows that Retromer deficiency, which is implicated in both Parkinson’s and Alzheimer’s Disease, increases human Tau truncation and toxicity. In the paper we also describe new tools to quantitate neurodegeneration with single synapse or axon resolution in intact Drosophila brains.
Innosuisse article on ALS project
Innosuisse support enables us to develop novel potential gene therapies for the motor neuron disease Amyotrophic lateral sclerosis (ALS). Read more in this article by Innosuisse about the project.
Brain ‘noise’ keeps nerve connections young
Nice article by Giorgia Guglielmi on EPFL news about our paper on miniature neurotransmission and ageing.
Minis maintain synapses
Exciting new publication from the lab on miniature neurotransmission and ageing led by Soumya. In the paper we describe a new adult Drosophila motor synaptic terminal NMJ preparation, genetic tools and electrophysiology methods. We use the prep to examine the effects of ageing on motor synapses. We find that synaptic terminal boutons fragment into smaller (…)