Jessie Mosso

Jessie Mosso graduated from an engineering school in France and obtained a master’s degree in Physics (ESPCI Paris) and in Neuroscience (Sorbonne Université, Paris) in 2019. During her graduate studies, she conducted research projects on the topic of dissolution dynamic nuclear polarization (d-DNP) at UC San Francisco and École Normale Supérieure, Paris.

Jessie joined EPFL in September 2019 to start a PhD in the CIBM and LIFMET under the supervision of Dr. Cristina Cudalbu and Prof. Rolf Gruetter. Her thesis research consists in the implementation of diffusion weighted spectroscopy (DWS) and imaging (DWI) at 14.1T to probe brain microstructure alterations in a preclinical model of hepatic encephalopathy (HE). Subprojects of her thesis involve FDG-PET imaging to study energy metabolism in chronic hepatic encephalopathy and validations of PCA denoising techniques for MRS data.

She defended her PhD thesis in 2023, and continued to pursue her research interests as a CIBM research staff till mid-2024. In 2024 Jessie became a Postdoctoral Research Fellow at New York University Grossman School of Medicine.

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PhD Thesis

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

2024 ISMRM I.I. Rabi Young Investigator Award Winner

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Dr. Jessie Mosso receives the EPFL Physics Doctoral Thesis Award 2024 and Best 8% Distinction of the Doctoral School

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Insights from the downfield proton MR spectrum: establishing peak assignments and novel pathophysiologic findings in hepatic encephalopathy @ ISMRM 2025 – Magna Cum Laude Merit Award

Metabolite-cycling at 14.1T using SPECIAL and diffusion-weighted SPECIAL @ ISMRM 2024 – Summa Cum Laude Merit Award

Improved glutamine detection using diffusion-weighted SPECIAL at 14.1T @ISMRM 2023

Diffusion MRI and MRS probe cerebellar microstructure alterations in the rat developing brain during hepatic encephalopathy @ISMRM 2022

Diffusion-weighted magnetic resonance spectroscopy in the cerebellum of a rat model of hepatic encephalopathy at 14.1T @ISMRM 2021 Magna Cum Laude Merit Award

Multimodal assessment of brain energy metabolism in a rat model of hepatic encephalopathy using 1H-MRS and 18F-FDG PET – a pilot study @ISMRM 2020

New insights into brain energy metabolism in type C hepatic encephalopathy: a dual 18F-FDG PET and 9.4T 1H MRS preclinical study @CIBM Breakfast and Science Seminar

Publications

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T

D. Simicic; B. Alves; J. Mosso; R. B. van Heeswijk; G. Briand et al. 

NMR in biomedicine. 2025. Vol. 38, num. 2. DOI : 10.1002/nbm.5304.

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Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application

B. Alves; D. Simicic; J. Mosso; T. P. Lê; G. M. A. Briand et al. 

NMR in Biomedicine. 2024. Vol. 37, num. 11. DOI : 10.1002/nbm.5211.

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Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

J. Mosso; G. Briand; K. Pierzchala; D. Simicic; A. Sierra et al. 

Frontiers In Neuroscience. 2024. Vol. 18, p. 1344076. DOI : 10.3389/fnins.2024.1344076.

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Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

C. Ligneul; C. Najac; A. Doring; C. Beaulieu; F. Branzoli et al. 

Magnetic Resonance In Medicine. 2023. Vol. 91, num. 3, p. 860 – 885. DOI : 10.1002/mrm.29877.

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Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

J. Mosso; D. Simicic; B. Lanz; R. Gruetter; C. Cudalbu 

Magnetic Resonance In Medicine. 2023. DOI : 10.1002/mrm.29805.

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New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al. 

2023. 20th Symposium of the International-Society-for-Hepatic-Encephalopathy-and-Nitrogen-Metabolism, Bad Zwischenahn, GERMANY, SEP 27-29, 2023. p. S12 – S12. DOI : 10.14309/01.ajg.0000948348.20966.21.

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Lessons on brain edema in HE: from cellular to animal models and clinical studies

K. Pierzchala; A. Hadjihambi; J. Mosso; R. Jalan; C. F. F. Rose et al. 

Metabolic Brain Disease. 2023. DOI : 10.1007/s11011-023-01269-5.

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New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

J. J. Mosso / R. Gruetter; C. R. Cudalbu (Dir.)  

Lausanne, EPFL, 2023. 

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MP-PCA denoising for diffusion MRS data: promises and pitfalls

J. Mosso; D. Simicic; K. Simsek; R. Kreis; C. Cudalbu et al. 

Neuroimage. 2022. Vol. 263, p. 119634. DOI : 10.1016/j.neuroimage.2022.119634.

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PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

J. Mosso; T. Yin; C. Poitry-Yamate; D. Simicic; M. Lepore et al. 

Analytical Biochemistry. 2022. Vol. 647, p. 114606. DOI : 10.1016/j.ab.2022.114606.

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