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Felix Naef and Li Tang Win SNSF Sinergia Grants

— Felix Naef and Li Tang, both Professors at the EPFL's Institute of Bioengineering (IBI), have been awarded major collaborative Sinergia grants by the Swiss National Science Foundation (SNSF).

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How the circadian clock regulates liver genes in time and space

— EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle.

Felix Naef. Credit: Alain Herzog (EPFL)

Felix Naef elected EMBO Member

— The European Molecular Biology Organization (EMBO) has elected 63 new life scientists to membership, joining more than 1800 of the best researchers in Europe and the world. Among the new members is Professor Felix Naef at EPFL’s Institute of Bioengineering.

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Transcriptional bursting of a mammalian gene after stimulation

— Increasing evidence from single cell studies indicates that gene transcription in mammals is fundamentally stochastic, occurring in short and intense transcriptional bursts followed by longer ‘off’ time. However, how these ‘on’ and ‘off’ transitions are modulated in single cells to increase gene expression upon stimulation is poorly characterized.

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Mammalian Genes Transcription.

— Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics.

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