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2024
Journal Articles
Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations
2024. DOI : 10.1101/2024.04.08.588507.2023
Journal Articles
Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling
Cell Reports Methods. 2023-08-28. Vol. 3, num. 8, p. 100545. DOI : 10.1016/j.crmeth.2023.100545.Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
Science. 2023-02-03. Vol. 379, num. 6631, p. 478-483. DOI : 10.1126/science.add0846.Reviews
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Annual Review Of Pathology-Mechanisms Of Disease. 2023-01-01. Vol. 18, p. 439-466. DOI : 10.1146/annurev-pathmechdis-031521-024831.Theses
Statistical physics of periodic biological processes
Lausanne, EPFL, 2023.2022
Journal Articles
V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
Journal of Cell Biology. 2022-10-31. Vol. 222, num. 1. DOI : 10.1083/jcb.202205045.Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver
Plos Genetics. 2022-08-01. Vol. 18, num. 8, p. e1009903. DOI : 10.1371/journal.pgen.1009903.Ribo-DT: An automated pipeline for inferring codon dwell times from ribosome profiling data
Methods. 2022-07-01. Vol. 203, p. 10-16. DOI : 10.1016/j.ymeth.2021.10.004.2021
Journal Articles
Comment on “Circadian rhythms in the absence of the clock gene Bmal1”
Science. 2021-04-16. Vol. 372, num. 6539, p. eabf0922. DOI : 10.1126/science.abf0922.The Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults
Nutrients. 2021-03-23. Vol. 13, num. 3, p. 1042. DOI : 10.3390/nu13031042.The circadian oscillator analysed at the single-transcript level
Molecular Systems Biology. 2021-03-01. Vol. 17, num. 3, p. e10135. DOI : 10.15252/msb.202010135.Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle
PLOS Genetics. 2021-02-01. Vol. 17, num. 2, p. e1009350. DOI : 10.1371/journal.pgen.1009350.Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2021-01-19. Vol. 118, num. 3, p. e2015803118. DOI : 10.1073/pnas.2015803118.Space-time logic of liver gene expression at sub-lobular scale
Nature Metabolism. 2021-01-11. Vol. 3, num. 1, p. 43-58. DOI : 10.1038/s42255-020-00323-1.Theses
Circadian dynamics of RNA localisation in the mammalian liver
Lausanne, EPFL, 2021.2020
Journal Articles
Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020-04-28. Vol. 117, num. 17, p. 9630-9641. DOI : 10.1073/pnas.1918145117.Reviews
What determines eukaryotic translation elongation: recent molecular and quantitative analyses of protein synthesis
Open Biology. 2020-12-09. Vol. 10, num. 12, p. 200292. DOI : 10.1098/rsob.200292.Theses
Inference methods for the study of interacting biological oscillators in single-cells
Lausanne, EPFL, 2020.2019
Journal Articles
Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex
Proceedings of the National Academy of Sciences. 2019-12-17. Vol. 116, num. 51, p. 25773-25783. DOI : 10.1073/pnas.1910590116.Low-dimensional dynamics of two coupled biological oscillators
Nature Physics. 2019-10-01. Vol. 15, num. 10, p. 1086-1094. DOI : 10.1038/s41567-019-0598-1.Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells
Nature Methods. 2019-07-01. Vol. 16, num. 7, p. 640-648. DOI : 10.1038/s41592-019-0455-2.Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells
Scientific Reports. 2019-03-29. Vol. 9, p. 5372. DOI : 10.1038/s41598-019-41870-2.Differential regulation of RNA polymerase III genes during liver regeneration
Nucleic Acids Research. 2019-02-28. Vol. 47, num. 4, p. 1786-1796. DOI : 10.1093/nar/gky1282.The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Cell Metabolism. 2019-02-05. Vol. 29, num. 2, p. 362-382.e8. DOI : 10.1016/j.cmet.2018.09.023.Memory and relatedness of transcriptional activity in mammalian cell lineages
Nature Communications. 2019. Vol. 10, num. 1, p. 1-11. DOI : 10.1038/s41467-019-09189-8.Conference Papers
Organization of temporal gene expression: from circadian clocks to promoter cycles and back
2019-07-01. p. 49-49.Theses
Tissue-specific circadian transcriptional regulation
Lausanne, EPFL, 2019.2018
Journal Articles
Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
Genes & Development. 2018-11-01. Vol. 32, num. 21-22, p. 1359-1360. DOI : 10.1101/gad.320911.118.Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates
Molecular Cell. 2018-09-20. Vol. 71, num. 6, p. 1079-1091.e9. DOI : 10.1016/j.molcel.2018.07.023.Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs
GENOME RESEARCH. 2018. Vol. 28, num. 2, p. 182-191. DOI : 10.1101/gr.222430.117.Modulation of transcriptional burst frequency by histone acetylation
Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115, num. 27, p. 7153-7158. DOI : 10.1073/pnas.1722330115.Clock-dependent chromatin topology modulates circadian transcription and behavior
GENES AND DEVELOPMENT. 2018. Vol. 32, num. 05-juin-2018, p. 347-358. DOI : 10.1101/gad.312397.118.Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver
Proceedings of the National Academy of Sciences of the United States of America. 2018. Vol. 115, num. 8, p. E1916-E1925. DOI : 10.1073/pnas.1715225115.Conference Papers
Long- and short-term molecular consequences of sleep loss in mice
2018-09-01. 24th Congress of the European-Sleep-Research-Society (ESRS), Basel, SWITZERLAND, Sep 25-28, 2018.Reviews
Rhythms of the Genome: Circadian Dynamics from Chromatin Topology, Tissue-Specific Gene Expression, to Behavior
Trends In Genetics. 2018-12-01. Vol. 34, num. 12, p. 915-926. DOI : 10.1016/j.tig.2018.09.005.Theses
Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver
Lausanne, EPFL, 2018.Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells
Lausanne, EPFL, 2018.2017
Journal Articles
Guidelines for Genome-Scale Analysis of Biological Rhythms
Journal Of Biological Rhythms. 2017. Vol. 32, num. 5, p. 380-393. DOI : 10.1177/0748730417728663.Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome
Cell Reports. 2017. Vol. 20, num. 7, p. 1729-1743. DOI : 10.1016/j.celrep.2017.07.065.A new promoter element associated with daily time keeping in Drosophila
Nucleic Acids Research. 2017. Vol. 45, num. 11, p. 6459-6470. DOI : 10.1093/nar/gkx268.Transcriptional regulatory logic of the diurnal cycle in the mouse liver
PLoS Biology. 2017. Vol. 15, num. 4, p. e2001069. DOI : 10.1371/journal.pbio.2001069.Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World
Cold Spring Harbor Perspectives In Biology. 2017. Vol. 9, num. 3, p. a028720. DOI : 10.1101/cshperspect.a028720.Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver
Cell Metabolism. 2017. Vol. 25, num. 1, p. 102-117. DOI : 10.1016/j.cmet.2016.10.003.Reviews
What shapes eukaryotic transcriptional bursting?
Molecular Biosystems. 2017. Vol. 13, num. 7, p. 1280-1290. DOI : 10.1039/c7mb00154a.Ribosome profiling and dynamic regulation of translation in mammals
Current Opinion In Genetics & Development. 2017. Vol. 43, p. 120-127. DOI : 10.1016/j.gde.2017.03.005.Theses
Rhythmic modulation of transcriptional burst frequency in circadian gene promoters
Lausanne, EPFL, 2017.Rhythmic and clock-dependent chromatin loops regulate circadian gene expression
Lausanne, EPFL, 2017.2016
Journal Articles
Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp
Genes & Development. 2016-09-01. Vol. 30, num. 17, p. 2005-2017. DOI : 10.1101/gad.287094.116.Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling
Biophysical journal. 2016. Vol. 110, num. 7, p. 1574-81. DOI : 10.1016/j.bpj.2016.02.035.Theses
Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver
Lausanne, EPFL, 2016.Circadian rhythm and cell cycle
Lausanne, EPFL, 2016.Mechanisms of centrosome separation in C. elegans
Lausanne, EPFL, 2016.Student Projects
Learning from Tokyo: translation, seuils et interstices à Berlin
2016.2015
Journal Articles
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2015. Vol. 112, num. 47, p. E6579-E6588. DOI : 10.1073/pnas.1515308112.Structure of silent transcription intervals and noise characteristics of mammalian genes
Molecular Systems Biology. 2015. Vol. 11, num. 7, p. 823-823. DOI : 10.15252/msb.20156257.CAST: An automated segmentation and tracking tool for the analysis of transcriptional kinetics from single-cell time-lapse recordings
Methods (San Diego, Calif.). 2015. Vol. 58, p. 3-11. DOI : 10.1016/j.ymeth.2015.04.023.Quantitative Analysis and Modeling Probe Polarity Establishment in C. elegans Embryos
Biophysical journal. 2015. Vol. 108, num. 4, p. 799-809. DOI : 10.1016/j.bpj.2014.12.022.Theses
Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform
Lausanne, EPFL, 2015.Talks
Culture, Argent, Public et Société
Cycle La Culture Créatrice de Valeurs, Palais Eynard, Genève, Suisse, Novembre 23, 2015.2014
Journal Articles
Characteristic bimodal profiles of RNA polymerase II at thousands of active mammalian promoters
Genome Biology. 2014. Vol. 15, num. 6, p. R85. DOI : 10.1186/gb-2014-15-6-r85.Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
Molecular Systems Biology. 2014. Vol. 10, num. 7, p. 739. DOI : 10.15252/msb.20145218.Non-Circadian Expression Masking Clock-Driven Weak Transcription Rhythms in U2OS Cells
Plos One. 2014. Vol. 9, num. 7, p. e102238. DOI : 10.1371/journal.pone.0102238.Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription
Genes & Development. 2014. Vol. 28, num. 15, p. 1695-1709. DOI : 10.1101/gad.244434.114.Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014. Vol. 111, num. 1, p. 167-172. DOI : 10.1073/pnas.1314066111.Theses
Modeling of transcription mechanisms in mammals from kinetic measurements in single cells
Lausanne, EPFL, 2014.Mathematical models and computational methods for the analysis of genome-scale protein synthesis
Lausanne, EPFL, 2014.Spatio-temporal synchronization of biological oscillators
Lausanne, EPFL, 2014.Computational studies in epigenomics using histone modification data
Lausanne, EPFL, 2014.Context-specific regulation of BMAL1 target genes during the circadian rhythm in mouse
Lausanne, EPFL, 2014.Antibiotic-Induced Killing and Persistence of Mycobacteria
Lausanne, EPFL, 2014.2013
Journal Articles
Stimulus-induced modulation of transcriptional bursting in a single mammalian gene
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013. Vol. 110, num. 51, p. 20563-20568. DOI : 10.1073/pnas.1312310110.Analysis of precision in chemical oscillators: implications for circadian clocks
Physical biology. 2013. Vol. 10, num. 5, p. 056005. DOI : 10.1088/1478-3975/10/5/056005.A chemostat array enables the spatio-temporal analysis of the yeast proteome
Proceedings of the National Academy of Sciences of the United States of America. 2013. Vol. 110, num. 39, p. 15842-15847. DOI : 10.1073/pnas.1308265110.Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics
Nature methods. 2013. Vol. 10, num. 6, p. 570-6. DOI : 10.1038/nmeth.2441.The CORALIE survey for southern extrasolar planets XVII. New and updated long period and massive planets
Astronomy & Astrophysics. 2013. Vol. 551, p. A90. DOI : 10.1051/0004-6361/201219639.The Circadian Clock Coordinates Ribosome Biogenesis
Plos Biology. 2013. Vol. 11, num. 1, p. e1001455. DOI : 10.1371/journal.pbio.1001455.Theses
Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries
Lausanne, EPFL, 2013.Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles
Lausanne, EPFL, 2013.Quantitative analysis and mathematical modeling of polarity establishment in C. elegans embryos
Lausanne, EPFL, 2013.Sliced Inverse Regression for Lifetimes and a Remark on High-Dimensional Graphical Models
Lausanne, EPFL, 2013.Molecular Modeling of Membrane Embedded Proteins
Lausanne, EPFL, 2013.Involvement of the THO complex subunit Thp2 in telomere stability
Lausanne, EPFL, 2013.A microfluidic live-cell imaging platform to study large collections of microbial genotypes
Lausanne, EPFL, 2013.2012
Journal Articles
Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles
Plos Biology. 2012. Vol. 10, num. 11, p. e1001442. DOI : 10.1371/journal.pbio.1001442.Promotion of Science among Youngsters: Today’s Crucial Mission for Tomorrow’s Society
Chimia. 2012. Vol. 66, num. 11, p. 817-817.Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally
Science. 2012. Vol. 338, num. 6105, p. 379-383. DOI : 10.1126/science.1217726.Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome
Molecular Cell. 2012. Vol. 48, num. 2, p. 277-287. DOI : 10.1016/j.molcel.2012.08.012.Theses
Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics
Lausanne, EPFL, 2012.2011
Journal Articles
Mammalian genes are transcribed with widely different bursting kinetics
Science (New York, N.Y.). 2011. Vol. 332, num. 6028, p. 472-4. DOI : 10.1126/science.1198817.Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains
Biophysical journal. 2011. Vol. 101, num. 2, p. 287-96. DOI : 10.1016/j.bpj.2011.05.060.Computational analysis of protein-DNA interactions from ChIP-seq data
Methods in molecular biology (Clifton, N.J.). 2011. Vol. 786, p. 263-73. DOI : 10.1007/978-1-61779-292-2_16.Origins and consequences of transcriptional discontinuity
Current opinion in cell biology. 2011. Vol. 23, num. 6, p. 657-662. DOI : 10.1016/j.ceb.2011.09.004.Analysis of the dynamics of limb transcriptomes during mouse development
BMC developmental biology. 2011. Vol. 11, p. 47. DOI : 10.1186/1471-213X-11-47.Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver
PLoS biology. 2011. Vol. 9, num. 2, p. e1000595. DOI : 10.1371/journal.pbio.1000595.Theses
On the Precision of Circadian Oscillators
Lausanne, EPFL, 2011.On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver
Lausanne, EPFL, 2011.Assembly Mechanisms and Cellular Effects of Bacterial Pore-Forming Toxins
Lausanne, EPFL, 2011.2010
Journal Articles
The CORALIE survey for southern extrasolar planets XVI. Discovery of a planetary system around HD 147018 and of two long period and massive planets orbiting HD 171238 and HD 204313
Astronomy & Astrophysics. 2010. Vol. 511, p. A45. DOI : 10.1051/0004-6361/200912136.Information processing in cells and tissues (IPCAT’2009): from small scale dynamics to understanding systems behavior
Bio Systems. 2010. Vol. 102, num. 1, p. 1-2. DOI : 10.1016/j.biosystems.2010.07.015.ASSET: A robust algorithm for the automated segmentation and standardization of early Caenorhabditis elegans embryos
Developmental dynamics. 2010. Vol. 239, num. 12, p. 3285-96. DOI : 10.1002/dvdy.22486.Publication_full_list_Naef.pdf
Warning
Please note that the publication lists from Infoscience integrated into the EPFL website, lab or people pages are frozen following the launch of the new version of platform. The owners of these pages are invited to recreate their publication list from Infoscience. For any assistance, please consult the Infoscience help or contact support.