Publications
Journal Articles
Google Scholar profile; ORCID ID
*: corresponding author; #: equal contribution
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Nature 2024, 634, 712-720.
Highlighted: EPFL News ; ACIR ; News Medical Life Sciences ; News Medical ; EurekAlert! ; MDLinx ; Yahoo News ; Technology Networks ; ecancer ; Mirage ; ecancer ; myscience ; Science Alert ; Medical Xpress ; British Society for Haematology ; CheckOrphan ; Canaltech
Single-cell CAR T atlas reveals type2 function in 8-year leukemia remission
Nature 2024, 634, 702-711.
Highlighted: Yale Engineering ; News Medical Life Sciences ; EurekAlert! ; MDLinx ; Yahoo News ; Technology Networks ; ecancer ; Mirage ; ecancer ; myscience ; Science Alert ; Medical Xpress ; British Society for Haematology ; CheckOrphan ; Canaltech
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
Nature Biotechnology 2024, 42, 1693-1704. Cover story of Nature Biotechnology, Volume 42 Issue 11, November 2024.
Highlighted: EPFL News ; Lifespan.io ; New Atlas ; News Medical Life Sciences ; Technology Networks ;
A redox-responsive prodrug for tumor-targeted glutamine restriction
Journal of Controlled Release 2024, 368, 251-264.
Smart chemistry for traceless release of anticancer therapeutics
Biomaterials 2023, 303, 122353.
Rational design of chemically controlled antibodies and protein therapeutics
ACS Chemical Biolology 2023, 18, 1259-1265.
Microfluidic T Cell Selection by Cellular Avidity
Advanced Healthcare Materials 2022, 2200169.
BCG Hydrogel Promotes CTSS-Mediated Antigen Processing and Presentation, Thereby Suppressing Metastasis and Prolonging Survival in Melanoma
Journal for ImmunoTherapy of Cancer 2022, 10, e004133.
Cancer-Cell Stiffening via Cholesterol Depletion Enhances Adoptive T-cell Therapy
Nature Biomedical Engineering 2021, 5, 1411-1425. Full-text available. Highlighted by Editorial of Nature Biomedical Eningeering, Volume 5 Issue 12, December 2021.
Highlighted: EPFL News ; RTS ; Le Matin ; Medical Press
Delivery of STING agonists for adjuvanting subunit vaccines
Advanced Drug Delivery Reviews 2021, 179, 114020.
Switchable Immune Modulator for Tumor-Specific Activation of Anticancer Immunity
Science Advances 2021, 7, eabg7291.
Highlighted: EPFL News ; RCI-Radio Canada ; Mirage News ; Medical Press
A Manganese Phosphate Nanocluster Activates the cGAS-STING Pathway for Enhanced Cancer Immunotherapy
Advanced Therapeutics 2021, 4, 2100065.
Metabolic Reprogramming of Terminally Exhausted CD8+ T cells by IL-10 Enhances Anti-Tumor Immunity
Nature Immunology 2021, 22, 746-756. Full-text available. Cover story of Nature Immunology, Volume 22 Issue 6, June 2021.
Highlighted: EPFL News ; RTS ; ACIR ; Nature middle east
Cytokine Engineering for Targeted Cancer Immunotherapy
Current Opinion in Chemical Biology 2021, 62, 43-52.
T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles
Materials Horizons 2020, 7, 3196-3200. Cover story of Materials Horizons Issue 12, December.
Highlighted: EPFL News; Materials Horizons Emerging Investigator Series.
Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine
ACS Central Science 2020, 6, 3, 404–412.
Highlighted: EPFL News
Synthetic 3D scaffolds for cancer immunotherapy
Current Opinion in Biotechnology 2020, 65, 1-8.
Donor-Cell Engineering with GSK3 Inhibitor-Loaded Nanoparticles Enhances Engraftment Following in Utero Transplantation
Blood 2019, 34 (22): 1983–1995.
A Magnetic Nanovaccine Enhances Cancer Immunotherapy
ACS Central Science 2019, 5, 747-749. DOI: 10.1021/acscentsci.9b00325.
Redox-Responsive Interleukin-2 Nanogel Specifically and Safely Promotes the Proliferation and Memory Precursor Differentiation of Tumor-Reactive T-Cells
Biomaterials Science 2019, 7, 1345-1357. DOI: 10.1039/c8bm01556b. Invited contribution as Biomaterials Science Emerging Investigator
Surgery-free injectable macroscale biomaterials for local cancer immunotherapy
Biomaterials Science 2019, 7, 733-749. DOI : 10.1039/c8bm01470a. Invited review.
Engineering Cancer Vaccines Using Stimuli-Responsive Biomaterials
Nano Research 2018, 11, 5355–5371. DOI : 10.1007/s12274-018-2162-1. Invited review. Special issue: 2018 Nano Research Young Innovators (NR45) Award in nanobiotechnology
Enhancing T-cell Therapy Through TCR Signaling-Responsive Nanoparticle Drug Delivery
Nature Biotechnology 2018, 36, 707-716. DOI : 10.1038/nbt.4181. Cover story of Nature Biotechnology, Volume 36 Issue 8, August 2018. News & Views “A backpack revs up T-cell activity” in Nat. Biotech.
Highlighted: MIT News, EPFL News, EurekAlert!, Phys.org, Nanowerk, My Science, eCancer, Health Canal, Medindia, Madrid, UPI.com, Science and Enterprise, Brinkwire, Sina, BioArt
Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy
Frontiers in Immunology 2018, 9, 1499. DOI : 10.3389/fimmu.2018.01499. Invited review, total views 24,392.
Albumin as a “Trojan Horse” for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting
Biomaterials Science 2018, 6, 1189-1200. DOI : 10.1039/c8bm00149a.
Immunoengineering with Biomaterials for Enhanced Cancer Immunotherapy
WIREs Nanomedicine and Nanobiotechnology 2018, 10, e1506. DOI : 10.1002/wnan.1506. Invited review.
Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors
ACS Nano 2017, 11, 3089-3100. DOI : 10.1021/acsnano.7b00078.
High-Throughput Quantitation of Inorganic Nanoparticle Biodistribution at the Single-Cell Level Using Mass Cytometry
Nature Communications 2017, 8, 14069. DOI : 10.1038/ncomms14069.
Selective in vivo Metabolic Cell-Labeling-Mediated Cancer Targeting
Nature Chemical Biology 2017, 13, 415-424. DOI : 10.1038/nchembio.2297.
Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis
Proceedings of the National Academy of Sciences of the United States of America 2016, 113, E4601-4609. DOI : 10.1073/pnas.1603316113.
Highlighted: NIH Director’ Blog, FierceBiotech, Noodles, EurekAlert!, Technology.org, Nanotechnology Now, Drug Discovery & Development, Bioscience technology, Azonano, Science Daily, Laboratory Journal, Phys.org, Nanowerk, Engineering at Illinois.
In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates
Theranostics 2016, 6, 1467-1476. DOI : 10.7150/thno.16003.
Targeted Delivery of Immunomodulators to Lymph Nodes
Cell Reports 2016, 15, 1202-1213. DOI : 10.1016/j.celrep.2016.04.007.
Prior to EPFL
Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy
ACS Nano 2015, 9, 5072-5081. DOI : 10.1021/acsnano.5b00166.
Biomaterial Strategies for Immunomodulation
Annual Review of Biomedical Engineering 2015, 17, 317-349. DOI : 10.1146/annurev-bioeng-071813-104814.
Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting
Chemical Science 2015, 6, 2182-2186. DOI : 10.1039/C5SC00063G.
Investigating the Optimal Size of Anticancer Nanomedicine
Proceedings of the National Academy of Sciences of the United States of America 2014, 111, 15344-15349. DOI : 10.1073/pnas.1411499111. Highlighted: Engineering at Illinois, Nanowerk, MedicalXpress, Science Daily, Nanotechnology Now, Daily News, EurekAlert!, Azonano, Health Canal, Bionity, Controlled Environments, Technology Org., Nature Science-Business eXchange 7(43); doi:10.1038/scibx.2014.1275.
Smart Chemistry in Polymeric Nanomedicines
Chemical Society Reviews 2014, 43, 6982-7012. DOI : 10.1039/C4CS00133H.
Nonporous Silica Nanoparticles for Nanomedicine Applications
Nano Today 2013, 8, 290-312. DOI : 10.1016/j.nantod.2013.04.007.
Size-Dependent Tumor Penetration and In Vivo Efficacy of Monodisperse Drug-silica Nanoconjugates
Molecular Pharmaceutics 2013, 10, 883-892. DOI : 10.1021/mp300684a.
Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.
Journal of Materials Chemistry B 2013, 1, 5288-5297. DOI : 10.1039/C3TB20412J.
Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly
Biomacromolecules 2013, 14, 3706-3712. DOI : 10.1021/bm401086d.
Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability
Angewandte Chemie International Edition 2013, 52, 6435-6439. DOI : 10.1002/anie.201300497.
Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors
Angewandte Chemie International Edition 2015, 51, 12721-12726. DOI : 10.1002/anie.201205271. Highlighted: Nature Science-Business eXchange 5(45); doi:10.1038/scibx.2012.1193.
Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates
ACS Nano 2012, 6, 3954-3966. DOI : 10.1021/nn300149c
Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A
Journal of Transplantation 2012, Article ID 896141. DOI :10.1155/2012/896141.
Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles
Journal of Analytical Oncology 2012, 1, 1-9. DOI : 10.6000/1927-7229.2012.01.01.1.
The Therapeutic Efficacy of Camptothecin-Encapsulated Supramolecular Nanoparticles
Biomaterials 2011, 33, 1162-1169. DOI : 10.1016/j.biomaterials.2011.10.044.
Translocation of HIV TAT Peptide and Analogues Induced by Multiplexed Membrane and Cytoskeletal Interactions
Proceedings of the National Academy of Sciences of the United States of America 2011, 108, 16883-16888. DOI : 10.1073/pnas.1108795108.
Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression
FASEB Journal 2010, 24, 3927-3938. DOI : 10.1096/fj.10-154690.
Lymphatic Biodistribution of Polylactide Nanoparticles
Molecular Imaging 2010, 9, 153-162.
Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications
Microsc. Res. Tech. 2010, 73, 901-909. DOI : 10.1002/jemt.20824.
Nanopolymeric Therapeutics
MRS Bulletin 2009, 34, 422-431. DOI : 10.1557/mrs2009.118.
Immune control of tuberculosis by IFN-gamma-inducible LRG-47Hydrothermal Growth of Large-scale Micropatterned Arrays of Ultralong ZnO Nanowires and Nanobelts on Zinc Substrate
Chem. Commun. 2006, 3551-3553. DOI : 10.1039/B608151G.
Patents
Efficient and Stable Cell Surface Coupling of Nanoparticles
U.S. provisional patent application, 2015.
Carrier-Free Biologically-Active Protein Nanogels
US Patent 20150110740, 2015.
Silica Nanoparticle Agent Conjugates
US 61/418,230, 2010, WO PCT/US2011/062548, 2011 (TF09149).