Trono Lab – Laboratory of Virology and Genetics

Our research interest are Krab-Zinc finger protein, transposons and epigenetics.

Shown here is the internal, self-organised structure of a stem cell derived, human cerebral organoid. Rosettes of neural progenitor SOX2 positive radial glia (red) are interspersed with TUJ1 positive newborn neurons (green). Nuclei are marked in blue | © Christopher Playfoot & Didier Trono

How a protein keeps gene clusters quiet in the cell nucleolus

Published:27.09.24 — In a discovery that sheds light on the complex mechanisms of gene regulation, scientists at EPFL have uncovered a critical role for the protein ZNF274 in keeping certain gene clusters turned off by anchoring them to the cell nucleolus.

Exposing hiding lymphoma cells to the immune system

Published:13.02.24 — EPFL scientists uncover how cancer cells use certain proteins to shield themselves from immune attacks, offering new treatment perspectives with immediate application.

“Genomic time machine” reveals secrets of our DNA

Published:01.02.24 — EPFL researchers reveal a novel method for uncovering bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.

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