Brain tumours are the leading cause of cancer-related death among children and young adults. The most common and devastating types include diffuse high-grade gliomas and embryonal tumours. These tumour types pose significant challenges for targeted therapy due to intrinsic variability in molecular profiles within and between patients.
Our research aims to advance diagnostics in pediatric neuro-oncology and to optimize therapeutic decision-making with real-time data.
Our specific research areas are:
- Digital neuro-pathology: to perform intra- and interoperative diagnostics for patients with pediatric brain tumours based on AI, spatial transcriptomics, and digital tissue slides.
- Liquid biopsy in neuro-oncology: to develop methods for multi-modal and longitudinal monitoring of pediatric brain tumours based on cell-free DNA whole genome sequencing.
- Clinical cancer genomics: to study the genomic landscape of pediatric gliomas and in response to targeted therapies.