Mechanisms and functions of protein S-acylation

F. S. Mesquita; L. Abrami; M. E. Linder; S. X. Bamji; B. C. Dickinson et al. 

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

S-acylation: an orchestrator of the life cycle and function of membrane proteins

F. S. Mesquita; L. Abrami; A. Samurkas; F. G. van der Goot 

Dynamics of CLIMP-63 S-acylation control ER morphology

P. A. Sandoz; R. A. Denhardt-Eriksson; L. Abrami; L. A. Abriata; G. Spreemann et al. 

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

F. S. Mesquita; L. Abrami; L. Bracq; N. Panyain; V. Mercier et al. 

ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

M. Anwar; O. Sergeeva; L. Abrami; P. Liberali; G. D’Angelo et al. 

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

M. U. Anwar; F. G. van der Goot 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

Inhibitors of acyl protein thioesterases against microbial infections

G. Van Der Goot; F. Mesquita; L. Abrami; C. Tapparel Vu; V. Cagno 

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

M. U. Anwar; O. A. Sergeeva; L. Abrami; F. S. Mesquita; I. Lukonin et al. 

Local and substrate-specific S-palmitoylation determines subcellular localization of G alpha o

G. P. Solis; A. Kazemzadeh; L. Abrami; J. Valnohova; C. Alvarez et al. 

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

A. Carreras-Sureda; L. Abrami; K. Ji-Hee; W-A. Wang; C. Henry et al. 

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

F. S. Mesquita; L. Abrami; O. Sergeeva; P. Turelli; E. Qing et al. 

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

L. Abrami; M. Audagnotto; S. Ho; M. J. Marcaida; F. S. Mesquita et al. 

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

M. Blaustein; E. Piegari; C. M. Calejman; A. Vila; A. Amante et al. 

ANTXR2 as a novel player in skeletal muscle stem cells

S. Metti; L. J. Bracq; F. G. van der Goot; P. Bonaldo 

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

N. Piot; G. van der Goot; O. A. Sergeeva 

A toxic palmitoylation of Cdc42 enhances NF-kappa B signaling and drives a severe autoinflammatory syndrome

B. Bekhouche; A. Tourville; Y. Ravichandran; R. Tacine; L. Abrami et al. 

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

I. Castanon; J. T. Hannich; L. Abrami; F. Huber; M. Dubois et al. 

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

J. Buergi; L. Abrami; I. Castanon; L. A. Abriata; B. Kunz et al. 

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

M. R. Gadalla; L. Abrami; F. G. van der Goot; M. Veit 

Mammalian membrane trafficking as seen through the lens of bacterial toxins

F. S. Mesquita; F. G. van der Goot; O. A. Sergeeva 

Mapping and Analysis of the Complexity of Lipid Metabolism for Applications in Health and Sustainability

Use of deoxysphingolipids as anti-toxins and anti-virals

H. S. Riezman; J. T. Hannich; A. Galih; J. Gruenberg; F. G. Van Der Goot 

Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

P. Sandoz; C. C. G. Tremblay; G. van der Goot; M. Frechin 

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes

O. A. Sergeeva; F. G. van der Goot 

Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications

B. Cressiot; H. Ouldali; M. Pastoriza-Gallego; L. Bacri; F. G. Van der Goot et al. 

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

J. Gouttenoire; A. Pollan; L. Abrami; N. Oechslin; J. Mauron et al. 

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

R. Kathayat; Y. Cao; P. Elvira; P. Sandoz; M. Zaballa et al. 

Palmitoylation determines the subcellular localization of the hepatitis E virus ORF3 protein

J. Gouttenoire; P. Angela; A. Laurence; M. Maxime; D. T. V. Loan et al. 

The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics

M. Zaballa; F. van der Goot 

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

Analysis of cellular and drug action mechanisms in the malaria parasites using systems biology approaches

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

Modeling CLiMP-63 spatio-temporal distribution and its interplay with Post-translational modification

R. A. Denhardt-Eriksson; P. Sandoz; L. Gouzi Abrami; S. Ho; B. Kunz 

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

J. Burgi; B. Kunz; L. Abrami; J. Deuquet; A. Piersigilli et al. 

Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

S. Cabezas; S. Ho; U. Ros; M. E. Lanio; C. Alvarez et al. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

E. Perrody; L. Abrami; M. Feldman; B. Kunz; S. Urbe et al. 

Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

I. Iacovache; S. De Carlo; N. Cirauqui; M. Dal Peraro; F. G. van der Goot et al. 

Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction

J. Burgi; B. Xue; V. N. Uversky; F. G. van der Goot 

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

D. J. Klionsky; K. Abdelmohsen; A. Abe; M. J. Abedin; H. Abeliovich et al. 

Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling

M. Bischofberger; I. Iacovache; D. Boss; F. Naef; F. G. van der Goot et al. 

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

W-T. He; X-M. Zheng; Y-H. Zhang; Y-G. Gao; A-X. Song et al. 

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

T. Dallavilla; L. Abrami; P. A. Sandoz; G. Savoglidis; V. Hatzimanikatis et al. 

New Insight into the Catalytic and Inhibition Mechanism of the Human Acyl Protein Thioesterase

M. Audagnotto; S. Ho; P. Sandoz; N. Andenmatten; G. Van Der Goot et al. 

The Ins and Outs of Anthrax Toxin

S. Friebe; F. G. van der Goot; J. Buergi 

Pore-forming toxins: ancient, but never really out of fashion

M. Dal Peraro; F. G. Van Der Goot 

Protrusion-retraction switches and traction forces in spontaneous cell polarization

Mechanisms of centrosome separation in C. elegans

Bioengineering approaches in immunotherapy

Folding and Endocytosis of Anthrax Toxin Receptors

SwissPalm: Protein Palmitoylation database

M. Blanc; F. David; L. Abrami; D. Migliozzi; F. Armand et al. 

The SwissLipids knowledgebase for lipid biology

L. Aimo; R. Liechti; N. Hyka-Nouspikel; A. Niknejad; A. Gleizes et al. 

Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8

S. Friebe; J. Deuquet; F. G. van der Goot 

Kicking Out Pathogens in Exosomes

O. A. Sergeeva; F. G. van der Goot 

How many lives does CLIMP-63 have?

P. A. Sandoz; F. G. Van der Goot 

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

Study of mTOR palmitoylation

E. Cuenot 

Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging

S. Geissbuehler; A. Sharipov; A. Godinat; N. L. Bocchio; P. A. Sandoz et al. 

Novel mechanistic insights into anthrax toxin endocytosis

S. Friebe; L. Abrami; F. G. Van der Goot 

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

F. G. Van Der Goot; J. Gruenberg 

Mechanistic effects of protein palmitoylation and the cellular consequences thereof

S. Blaskovic; A. Adibekian; M. Blanc; F. G. van der Goot 

In-Depth Analysis of Mutations in Hyaline Fibromatosis Syndrome (HFS)

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

Mechanism and Function of S-palmitoylation in Capillary Morphogenesis Gene 2

Did Cholera Toxin Finally Get Caught?

F. Martinon; F. G. van der Goot 

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

L. Abrami; L. Brandi; M. Moayeri; M. J. Brown; B. A. Krantz et al. 

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

M. T. Degiacomi; I. Lacovache; L. Pernot; M. Chami; M. Kudryashev et al. 

Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF

A. K. Lakkaraju; G. van der Goot 

In-depth analysis of hyaline fibromatosis syndrome frameshift mutations at the same site reveal the necessity of personalized therapy

S. E. Yan; T. Lemmin; S. Salvi; E. Lausch; A. Superti-Furga et al. 

Biochemical Membrane Lipidomics during Drosophila Development

X. L. Guan; G. Cestra; G. Shui; A. Kuhrs; R. B. Schittenhelm et al. 

Anthrax toxin receptor 2a controls mitotic spindle positioning

I. Castanon; L. Abrami; L. Holtzer; C. P. Heisenberg; G. van der Goot et al. 

The Molecular Assembly of the Aerolysin Pore Reveals a Unique Swirling Membrane-Insertion Mechanism

M. Degiacomi; I. Iacovache; G. Van Der Goot; M. Dal Peraro 

What does S-palmitoylation do to membrane proteins?

S. Blaskovic; M. Blanc; G. van der Goot 

Palmitoylation, pathogens and their host

M. Blanc; S. Blaskovic; G. van der Goot 

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

J. M. Rojek; M-L. Moraz; C. Pythoud; S. Rothenberger; G. van der Goot et al. 

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

G. Imre; J. Heering; A-N. Takeda; M. Husmann; B. Thiede et al. 

Palmitoylated calnexin is a key component of the ribosome-translocon complex

A. K. K. Lakkaraju; L. Abrami; T. Lemmin; S. Blaskovic; B. Kunz et al. 

Pathogenic Pore-Forming Proteins: Function and Host Response

M. Bischofberger; I. Iacovache; G. van der Goot 

The dark sides of capillary morphogenesis gene 2

J. Deuquet; E. Lausch; A. Superti-Furga; G. van der Goot 

On chip cellular dielectric spectroscopy

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

Extending the aerolysin family: from bacteria to vertebrates

P. Szczesny; I. Iacovache; A. Muszewska; K. Ginalski; G. van der Goot et al. 

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

M. Pastoriza-Gallego; L. Rabah; G. Gibrat; B. Thiebot; G. van der Goot et al. 

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

J. Deuquet; E. Lausch; N. Guex; L. Abrami; S. Salvi et al. 

Pore-forming toxins induce multiple cellular responses promoting survival

M. R. Gonzalez; M. Bischofberger; B. Freche; S. Ho; R. G. Parton et al. 

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

O. Opota; I. Vallet-Gély; R. Vincentelli; C. Kellenberger; I. Iacovache et al. 

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

I. Iacovache; M. T. Degiacomi; L. Pernot; S. Ho; M. Schiltz et al. 

When cells and microbes meet in Krakow

K. Rajalingam; G. van der Goot 

Cellular Responses to Bacterial Pore-Forming Toxins

Folding and Structure of the Pore Forming Toxin Aerolysin

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

Assembly Mechanisms and Cellular Effects of Bacterial Pore-Forming Toxins