Finding a therapy against Parkinson’s disease remains a major challenge. The project proposed by this research team aims to explore the therapeutic potential of specific classes of bioactive compounds extracted from venoms of vipers and scorpions for the treatment of Parkinson’s disease. The project builds on the partners’ unique expertise and is a perfect example of the win-win benefits of conducting South-North collaborative research, as promoted by EXAF.
Keywords: Parkinson disease, Synucleinopathies, Alpha-synuclein, Animal venoms, Drug discovery
Dr Ines El Bini Dhouib
She is currently an Assistant Professor in physiology at Pasteur Institute of Tunisia since 2017.
Prof. Hilal Lashuel
He is an Associate Professor of life sciences and the director of the laboratory of molecular and chemical biology of neurodegeneration at the Brain Mind Institute, EPFL.
Our aim is to find a therapy for Parkinson’s disease. It’s a major challenge!
Research project
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder for which there are no effective treatments today. PD is caused by the loss of dopamine-producing neurons in specific brain regions but eventually spreads to different brain regions as the disease progresses. One key characteristic feature of the disease is the accumulation of proteinaceous aggregates, composed of the protein alpha-synuclein (α-syn) in the affected brain regions.
Increasing evidence suggests that the aggregation of the α-syn and its cell-to-cell propagation in the brain play central roles in the initiation and progression of PD and several other neurodegenerative diseases that are collectively known as synucleinopathies. Alpha-syn aggregates are toxic and bind to cell surface receptors such as integrins, matrix metalloproteases, or ionic channels on neuron and/or microglia, leading to chronic neuroinflammation and neuronal damage.
Accordingly, we hypothesise that specific ligands of integrins, matrix metalloproteases, and/or ionic channels could have a therapeutic effect on Parkinson’s disease. In this project, we aim to use an integrated platform of validated preclinical models and drug discovery assay developed in the Lashuel lab. The objective is to screen, identify and validate anti-PD drugs from vipers and scorpions venoms and assess their therapeutic potential for the treatment of Parkinson’s disease and other synucleinopathies.
9th Conference of Mediterranean Neuroscience Society MNS- Carthage Tunisia, 14- 18 October 2023 « Insights into Parkinson’s with Potassium Channels at the Forefront». Ines ELBini
3rd Young Researchers Colloquium, Pasteur Institute of Tunis, Tunisia. October 25, 26 and 27, 2023 « The Puzzle of Parkinson’s: Alpha-Synuclein Aggregates and Their Role». Ines ELBini
3rd ISN Tunisia Neuroscience School on Neuroimmunology and Neuroinflammation in Neurodegenerative diseases: Current Challenges and Therapeutics opportunities; 5-12 Mars 2023.
Organization of an open access conference : “Targeting alpha-synuclein aggregation for the treatment of Parkinson’s disease”, 2023 Presented by Pr. Abid Oueslati.
Organization of a Symposium as part of the 32nd Ion channels meeting at Sète, Montpellier France, 2023 “Ion channels as Therapeutic Targets in Motor Diseases”
Media
Research team
 | Dr Ines Elbini Research manager |  | Prof. Hilal Lahsuel Research manager Webpage |
| Dr Chedly Ellijimi Post-doc |  | Dre Anne-Laure Mahul Mellier Scientific collaborator Webpage | |
 | Nour-elhouda Neili PhD student |  | Yllza Jasiqi Laboratory technician |
| Zeineb Afifi Daassi Project administrator |
People who have previously worked on the project
Dr Ines El Bini Dhouib
Ines El Bini Dhouib is currently an Assistant Professor in physiology at Pasteur Institute of Tunisia since 2017. She earned her doctoral degree of biological sciences from Science Faculty of Tunis (Tunisia) in 2015 and her Bachelor and Master degree in biological sciences from Biotechnological Institute of Monastir (Tunisia) in 2007.
In addition to her research activities, she teaches neurophysiology and neurosciences in several international and national bachelors and masters program. Since 2014, Ines El Bini has over 28 refereed publications and more than 20 oral presentations in international and national scientific congress.
Hilal Lashuel is an Associate Professor of life sciences and the director of the laboratory of molecular and chemical biology of neurodegeneration at the Brain Mind Institute, EPFL.
Hilal Lashuel was a visiting Associate Professor at the Department of Neurology and Neurological Sciences at Stanford University (2012-2013) and served as the Executive Director of Qatar Biomedical Research Institute (2014 –2016). He is also the founder and CSO of ND BioSciences SA, a biotechnology company that is developing innovative solutions to accelerate the development of early diagnostics and therapies for neurodegenerative diseases.