The investigation of the future, or better, the future as a research habit, is at the core of HRC research platform. Pressure is on adaptability to climate change, socio-demographic shifts, economic and energy transitions, massive delocalization of populations, new or higher levels of risk. We can follow the return of life’s course into the debate about the city and the territory. In the dense sedimentation of rationalizations at work, dismantled or forgotten, the city territory contains potentials and possibilities that are crucial in a future of increasing migrations, demographic and sanitary crises, when the flexibility of space and its productivity become strategic. New coexistences and “space as a renewable resource” must be explored. The contemporary spatial, social and economic context asks for a redefinition of the modern biopolitical project, that is to say a project whose goals were to maintain, secure and render productive life. Today, multiple questions are raised by the ecological transition, the technological and urban economic transformations, the life course changes that largely intersect with space and urbanization issues. If the ordering of the urban environment, the spatial organization of resources and the medicalization of space were the main fields of the modern biopolitical project, we are today in need of redefining new conditions of “living together”, enlarged to human and nonhuman agencies. HRC aspires to contribute and clarify the enormous conceptual, material, and value-based arising issues.