2025
Journal Articles
Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening
BIOMEDICAL OPTICS EXPRESS. 2025. num. 2, p. 398 – 414. DOI : 10.1364/BOE.542362.Targeting protein-ligand neosurfaces with a generalizable deep learning tool
NATURE. 2025. DOI : 10.1038/s41586-024-08435-4.Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context
Neoplasia (New York, N.Y.). 2025. Vol. 59. DOI : 10.1016/j.neo.2024.101078.2024
Journal Articles
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma
JCI INSIGHT. 2024. Vol. 9, num. 14. DOI : 10.1172/jci.insight.169647.Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Nature Chemical Biology. 2024. DOI : 10.1038/s41589-024-01627-z.Fluorescent fatty acid conjugates for live cell imaging of peroxisomes
Nature Communications. 2024. Vol. 15, num. 4314. DOI : 10.1038/s41467-024-48679-2.Gentle Rhodamines for Live-Cell Fluorescence Microscopy
ACS Central Science. 2024. DOI : 10.1021/acscentsci.4c00616.2023
Journal Articles
Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Blood Advances. 2023. Vol. 8, num. 1, p. 1 – 13. DOI : 10.1182/bloodadvances.2023009964.Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles
Jacs Au. 2023. DOI : 10.1021/jacsau.3c00271.In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Blood Transfusion. 2023. Vol. 21, num. 4, p. 277 – 288. DOI : 10.2450/2022.0086-22.Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination
Nature Chemistry. 2023. DOI : 10.1038/s41557-023-01228-8.Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma
Cancer Science. 2023. DOI : 10.1111/cas.15878.Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes
Acs Sensors. 2023. DOI : 10.1021/acssensors.3c00073.Conference Papers
Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity
2023. p. S117 – S118.2022
Journal Articles
A covalently linked probe to monitor local membrane properties surrounding plasma membrane proteins
Journal Of Cell Biology. 2022. Vol. 222, num. 3, p. e202206119. DOI : 10.1083/jcb.202206119.High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Scientific Data. 2022. Vol. 9, num. 610, p. 1 – 12. DOI : 10.1038/s41597-022-01733-4.Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall
Acs Chemical Biology. 2022. Vol. 17, num. 9, p. 2418 – 2424. DOI : 10.1021/acschembio.2c00496.Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications. 2022. Vol. 13, num. 1, p. 3823. DOI : 10.1038/s41467-022-31428-8.Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin
Journal Of Medicinal Chemistry. 2022. Vol. 65, num. 14, p. 9735 – 9749. DOI : 10.1021/acs.jmedchem.2c00306.Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Pharmaceuticals. 2022. Vol. 15, num. 6, p. 669. DOI : 10.3390/ph15060669.Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Cancers. 2022. Vol. 14, num. 6, p. 1575. DOI : 10.3390/cancers14061575.Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Current Research in Virological Science. 2022. Vol. 3, p. 100019. DOI : 10.1016/j.crviro.2022.100019.Conference Papers
A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery
2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S38 – S38.2021
Journal Articles
Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Mbio. 2021. Vol. 12, num. 6, p. e02621 – 21. DOI : 10.1128/mBio.02621-21.Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie International Edition. 2021. Vol. 60, num. 40, p. 21702 – 21707. DOI : 10.1002/anie.202107815.Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
International Journal of Molecular Sciences. 2021. Vol. 22, num. 8, p. 4293. DOI : 10.3390/ijms22084293.Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Viruses. 2021. Vol. 13, num. 1, p. 128. DOI : 10.3390/v13010128.Patents
Cathepsin inhibitors and uses thereof
WO2021191412; EP3884948.
2021.2020
Journal Articles
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
Antimicrobial Agents and Chemotherapy. 2020. Vol. 64, num. 9, p. e01002 – 20. DOI : 10.1128/AAC.01002-20.A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Scientific Data. 2020. Vol. 7, num. 1, p. 265. DOI : 10.1038/s41597-020-00604-0.Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science. 2020. Vol. 11, num. 30, p. 7858 – 7863. DOI : 10.1039/D0SC01944E.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Nature Biomedical Engineering. 2020. Vol. 4, p. 863 – 874. DOI : 10.1038/s41551-020-0565-2.Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics
mBio. 2020. Vol. 11, num. 3, p. e00538 – 20. DOI : 10.1128/mBio.00538-20.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2020. p. 201913904. DOI : 10.1073/pnas.1913904117.Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging
Acs Photonics. 2020. Vol. 7, num. 1, p. 105 – 113. DOI : 10.1021/acsphotonics.9b01152.2019
Journal Articles
A ligand-based system for receptor-specific delivery of proteins
Scientific Reports. 2019. Vol. 9, p. 19214. DOI : 10.1038/s41598-019-55797-1.Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Slas Discovery. 2019. p. 2472555219887142. DOI : 10.1177/2472555219887142.Photoactivation of silicon rhodamines via a light-induced protonation
Nature Communications. 2019. Vol. 10, p. 4580. DOI : 10.1038/s41467-019-12480-3.Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Plos One. 2019. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format
Platelets. 2019. Vol. 30, num. 5, p. 563 – 571. DOI : 10.1080/09537104.2018.1514106.A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Analytical Chemistry. 2019. Vol. 91, num. 1, p. 1098 – 1104. DOI : 10.1021/acs.analchem.8b04672.Patents
Sting inhibitors
WO2019201939; EP3556362.
2019.Sting inhibitors
WO2019122202; EP3502102.
2019.Sting inhibitors
WO2019122202; EP3502102.
2019.2018
Journal Articles
Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Biomedical Optics Express. 2018. Vol. 9, num. 10, p. 4714 – 4729. DOI : 10.1364/BOE.9.004714.Using Laser-Induced Rydberg Spectroscopy diagnostic for direct measurements of the local electric field in the edge region of NSTX/NSTX-U: Modeling
Review Of Scientific Instruments. 2018. Vol. 89, num. 10, p. 10C106. DOI : 10.1063/1.5038877.2017
Journal Articles
Red blood cells ageing markers: a multi-parametric analysis
Blood Transfusion. 2017. Vol. 15, num. 3, p. 239 – S2. DOI : 10.2450/2017.0318-16.Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.Luciferases with tunable emission wavelengths
Angewandte Chemie International Edition. 2017. Vol. 56, num. 46, p. 14556 – 14560. DOI : 10.1002/anie.201708277.Computational design of environmental sensors for the potent opioid fentanyl
eLife. 2017. Vol. 6. DOI : 10.7554/eLife.28909.2016
Journal Articles
Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy
Applied Optics. 2016. Vol. 55, num. 3, p. A86 – A94. DOI : 10.1364/Ao.55.000A86.Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.Screening out irrelevant cell-based models of disease
Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751 – 769. DOI : 10.1038/nrd.2016.175.Conference Papers
Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway
2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29 – 29.2015
Journal Articles
Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy
Optics Express. 2015. Vol. 23, num. 10, p. 13333 – 13347. DOI : 10.1364/OE.23.013333.Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Embo Reports. 2015. Vol. 16, num. 6, p. 741 – 752. DOI : 10.15252/embr.201540081.Conference Papers
Identification of CDC-48 inhibitors in C. elegans
2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389 – 389.Book Chapters
Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening
Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307 – 325.2014
Journal Articles
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284 – 301. DOI : 10.1016/j.ejmech.2014.06.078.Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols
Toxicology Letters. 2014. Vol. 229, num. 2, p. 374 – 380. DOI : 10.1016/j.toxlet.2014.07.002.Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland
Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369 – 376. DOI : 10.2174/1386207317666140323194716.Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion
Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538 – 548. DOI : 10.1016/j.chom.2014.09.008.Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening
Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80 – 8. DOI : 10.2174/13862073113166660062.Conference Papers
Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology
2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A – 50A.2013
Journal Articles
Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101 – 107. DOI : 10.1089/adt.2012.476.2012
Journal Articles
Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864 – 2875. DOI : 10.1021/ci300415d.2011
Journal Articles
Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch
CHIMIA. 2011. Vol. 65, p. 863 – 867. DOI : 10.2533/chimia.2011.863.2010
Journal Articles
An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425 – 40. DOI : 10.1016/j.bmc.2010.05.010.Leads for antitubercular compounds from kinase inhibitor library screens
Tuberculosis. 2010. Vol. 90, num. 6, p. 354 – 60. DOI : 10.1016/j.tube.2010.09.001.Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
Journal of Biological Chemistry. 2010. Vol. 285, num. 34, p. 26581 – 98. DOI : 10.1074/jbc.M110.113951.Optimization of microfluidic single cell trapping for long-term on-chip culture
Lab on a Chip. 2010. Vol. 10, num. 7, p. 857 – 863. DOI : 10.1039/b918055a.Patents
Preparation of nucleic acid templates for solid phase amplification
EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.
2010.2009
Journal Articles
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
Biochemistry. 2009. Vol. 48, num. 41, p. 9858 – 70. DOI : 10.1021/bi900957e.Patents
Preparation of templates for nucleic acid sequencing
ES2398808; EP2298930; US10710046; US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; ES2398808; EP2298930; US2012208194; EP1910559; HK1154636; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.
2009.2008
Journal Articles
Accurate whole human genome sequencing using reversible terminator chemistry
Nature. 2008. Vol. 456, num. 7218, p. 53 – 9. DOI : 10.1038/nature07517.A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.Patents
Method of Nucleotide Detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2008.2007
Journal Articles
Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha
PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.Low- to high-throughput analysis of telomerase modulators with Telospot
Nature Methods. 2007. Vol. 4, num. 10, p. 851 – 853. DOI : 10.1038/nmeth1099.Patents
Improved method of nucleotide detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2007.Conversion of amine- to carboxyl groups on solid surfaces
US7704543; US2007042109; EP1692090; WO2005030695.
2007.2006
Journal Articles
Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis
Chemistry – A European Journal. 2006. Vol. 12, num. 13, p. 3655 – 3671. DOI : 10.1002/chem.200501538.BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies
Nucleic Acids Research. 2006. Vol. 34, num. 3, p. e22. DOI : 10.1093/nar/gnj023.2004
Journal Articles
A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA
Analytical Chemistry. 2004. Vol. 76, num. 6, p. 1778 – 1787. DOI : 10.1021/ac034377+.2003
Patents
Nucleotide detection by fluorescence resonance energy transfer and methods thereof
BR0303224; NO20034592; NO20034592; AU2003226829; WO03068986.
2003.2001
Journal Articles
Synthesis and characterization of fluorescent and photoactivatable MIP-1alpha ligands and interactions with chemokine receptors CCR1 and CCR5
Journal of Medicinal Chemistry. 2001. Vol. 44, num. 2, p. 215 – 222. DOI : 10.1021/jm000982i.2000
Journal Articles
Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms
Nucleic acids research. 2000. Vol. 28, num. 20, p. e87. DOI : 10.1093/nar/28.20.e87.Patents
Methods of nucleic acid amplification and sequencing
US10370652; US2016319274; US9297006; US2014228254; US8652810; EP1634963; EP1117827; US2008160580; US7115400; DE69928683; EP1634963; DE69928683; AT311474; EP1117827; AU771073; EA004271; HU0105052; NZ510599; HK1042525; JP2002525125; AR021833; EE200100195; HU0105052; PL347125; BG105363; CN1325458; SK4292001; EA200100402; ZA200102420; CZ20011183; KR20010085860; EP1117827; TR200100911; BR9914159; NO20011303; NO20011303; AU6108899; CA2344575; WO0018957.
2000.