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2023
Journal Articles
In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Blood Transfusion. 2023-07-01. Vol. 21, num. 4, p. 277-288. DOI : 10.2450/2022.0086-22.Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Blood Advances. 2023-12-29. Vol. 8, num. 1, p. 1-13. DOI : 10.1182/bloodadvances.2023009964.Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes
Acs Sensors. 2023-06-19. DOI : 10.1021/acssensors.3c00073.Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma
Cancer Science. 2023-06-20. DOI : 10.1111/cas.15878.Conference Papers
Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity
2023-04-01. p. S117-S118.2022
Journal Articles
High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Scientific Data. 2022-10-08. Vol. 9, num. 610, p. 1-12. DOI : 10.1038/s41597-022-01733-4.Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications. 2022-07-02. Vol. 13, num. 1, p. 3823. DOI : 10.1038/s41467-022-31428-8.Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Pharmaceuticals. 2022-05-27. Vol. 15, num. 6, p. 669. DOI : 10.3390/ph15060669.Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Current Research in Virological Science. 2022. Vol. 3, p. 100019. DOI : 10.1016/j.crviro.2022.100019.Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Cancers. 2022-03-01. Vol. 14, num. 6, p. 1575. DOI : 10.3390/cancers14061575.Conference Papers
A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery
2022-01-01. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S38-S38.2021
Journal Articles
Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Mbio. 2021-11-01. Vol. 12, num. 6, p. e02621-21. DOI : 10.1128/mBio.02621-21.Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie-International Edition. 2021-08-25. Vol. 60, num. 40, p. 21702-21707. DOI : 10.1002/anie.202107815.Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
International Journal of Molecular Sciences. 2021-04-20. Vol. 22, num. 8, p. 4293. DOI : 10.3390/ijms22084293.Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Viruses. 2021-01-18. Vol. 13, num. 1, p. 128. DOI : 10.3390/v13010128.Patents
Cathepsin inhibitors and uses thereof
WO2021191412; EP3884948.
2021.2020
Journal Articles
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
Antimicrobial Agents and Chemotherapy. 2020-08-20. Vol. 64, num. 9, p. e01002-20. DOI : 10.1128/AAC.01002-20.A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Scientific Data. 2020-08-12. Vol. 7, num. 1, p. 265. DOI : 10.1038/s41597-020-00604-0.Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics
mBio. 2020-05-05. Vol. 11, num. 3, p. e00538-20. DOI : 10.1128/mBio.00538-20.Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science. 2020-06-26. Vol. 11, num. 30, p. 7858-7863. DOI : 10.1039/D0SC01944E.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Nature Biomedical Engineering. 2020-06-08. Vol. 4, p. 863–874. DOI : 10.1038/s41551-020-0565-2.Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging
Acs Photonics. 2020-01-01. Vol. 7, num. 1, p. 105-113. DOI : 10.1021/acsphotonics.9b01152.2019
Journal Articles
Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Slas Discovery. 2019-11-28. p. 2472555219887142. DOI : 10.1177/2472555219887142.Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019-08-21. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format
Platelets. 2019-01-01. Vol. 30, num. 5, p. 563-571. DOI : 10.1080/09537104.2018.1514106.Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Plos One. 2019-01-29. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Analytical Chemistry. 2019-01-01. Vol. 91, num. 1, p. 1098-1104. DOI : 10.1021/acs.analchem.8b04672.Patents
Sting inhibitors
WO2019201939; EP3556362.
2019.2018
Journal Articles
Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Biomedical Optics Express. 2018-10-01. Vol. 9, num. 10, p. 4714-4729. DOI : 10.1364/BOE.9.004714.Targeting STING with covalent small-molecule inhibitors
Nature. 2018. Vol. 559, num. 7713, p. 269-273. DOI : 10.1038/s41586-018-0287-8.High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy
JOURNAL OF LIPID RESEARCH. 2018. Vol. 59, num. 7, p. 1301-1310. DOI : 10.1194/jlr.D085217.2017
Journal Articles
Red blood cells ageing markers: a multi-parametric analysis
Blood Transfusion. 2017. Vol. 15, num. 3, p. 239-S2. DOI : 10.2450/2017.0318-16.Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.2016
Journal Articles
Screening out irrelevant cell-based models of disease
Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751-769. DOI : 10.1038/nrd.2016.175.Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy
Applied Optics. 2016. Vol. 55, num. 3, p. A86-A94. DOI : 10.1364/Ao.55.000A86.Conference Papers
Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway
2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29-29.2015
Journal Articles
Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Embo Reports. 2015. Vol. 16, num. 6, p. 741-752. DOI : 10.15252/embr.201540081.Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy
Optics Express. 2015. Vol. 23, num. 10, p. 13333-13347. DOI : 10.1364/OE.23.013333.Conference Papers
Identification of CDC-48 inhibitors in C. elegans
2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389-389.Book Chapters
Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening
Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307-325.2014
Journal Articles
Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols
Toxicology Letters. 2014. Vol. 229, num. 2, p. 374-380. DOI : 10.1016/j.toxlet.2014.07.002.Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion
Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538-548. DOI : 10.1016/j.chom.2014.09.008.Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284-301. DOI : 10.1016/j.ejmech.2014.06.078.Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland
Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369-376. DOI : 10.2174/1386207317666140323194716.Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening
Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80-8. DOI : 10.2174/13862073113166660062.Conference Papers
Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology
2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A-50A.2013
Journal Articles
Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from
Chemistry – A European Journal. 2013. Vol. 19, num. 14, p. 4596-4601. DOI : 10.1002/chem.201203296.Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101-107. DOI : 10.1089/adt.2012.476.2012
Journal Articles
Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864-2875. DOI : 10.1021/ci300415d.2011
Journal Articles
Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch
Chimia. 2011. Vol. 65, p. 863-867. DOI : 10.2533/chimia.2011.863.Chemical Biology Approaches to Membrane Homeostasis and Function
Chimia. 2011. Vol. 65, p. 849-852. DOI : 10.2533/chimia.2011.849.Student Projects
Multiplexed detection of nucleic acids – testing and benchmarking of a novel platform developed by Biocartis
2011.2010
Journal Articles
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
The Journal of biological chemistry. 2010. Vol. 285, num. 34, p. 26581-98. DOI : 10.1074/jbc.M110.113951.Leads for antitubercular compounds from kinase inhibitor library screens
Tuberculosis. 2010. Vol. 90, num. 6, p. 354-60. DOI : 10.1016/j.tube.2010.09.001.Optimization of microfluidic single cell trapping for long-term on-chip culture
Lab on a Chip. 2010. Vol. 10, num. 7, p. 857-863. DOI : 10.1039/b918055a.An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425-40. DOI : 10.1016/j.bmc.2010.05.010.Patents
Preparation of nucleic acid templates for solid phase amplification
EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.
2010.Student Projects
Development of high content image-based cell viability assays
2010.Cellular transfection of small interfering ribonucleic acids. Electroporation as an alternative to liposome-based delivery transfection methods
2010.2009
Journal Articles
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
Biochemistry. 2009. Vol. 48, num. 41, p. 9858-70. DOI : 10.1021/bi900957e.Patents
Preparation of templates for nucleic acid sequencing
ES2398808; EP2298930; US10710046; US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; ES2398808; EP2298930; US2012208194; EP1910559; HK1154636; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.
2009.2008
Journal Articles
Accurate whole human genome sequencing using reversible terminator chemistry
Nature. 2008. Vol. 456, num. 7218, p. 53-9. DOI : 10.1038/nature07517.A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.Patents
Method of Nucleotide Detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2008.2007
Journal Articles
Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha
PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.Low- to high-throughput analysis of telomerase modulators with Telospot
Nature Methods. 2007. Vol. 4, num. 10, p. 851-853. DOI : 10.1038/nmeth1099.Patents
Conversion of amine- to carboxyl groups on solid surfaces
US7704543; US2007042109; EP1692090; WO2005030695.
2007.Improved method of nucleotide detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2007.