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TNFα prevents FGF4-mediated rescue of astrocyte dysfunction and reactivity in human ALS models
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Nature. 2024. Vol. 631, num. 8019, p. 150 – 163. DOI : 10.1038/s41586-024-07504-y.Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells
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Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy
Human Molecular Genetics. 2023. DOI : 10.1093/hmg/ddad202.Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo
Acta Neuropathologica Communications. 2023. Vol. 11, num. 1, p. 157. DOI : 10.1186/s40478-023-01608-8.AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice
Human Molecular Genetics. 2023. DOI : 10.1093/hmg/ddad121.The role of the NF-kappaB pathway in Amyotrophic lateral sclerosis pathogenesis
Lausanne, EPFL, 2023.2022
Gene therapy against amyotrophic lateral sclerosis: a bicistronic AAV vector for RNAi against mutated SOD1
2022. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, SCOTLAND, Oct 11-14, 2022. p. A89 – A89.Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
Gene Therapy. 2022. DOI : 10.1038/s41434-022-00338-1.Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis
Glia. 2022. DOI : 10.1002/glia.24140.Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity
International Journal Of Molecular Sciences. 2022. Vol. 23, num. 1, p. 363. DOI : 10.3390/ijms23010363.2021
The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging
Science Translational Medicine. 2021. Vol. 13, num. 623, p. eabc7367. DOI : 10.1126/scitranslmed.abc7367.Proteins associated with the sarcomere and costamere in hearts are dysregulated in two mouse models of spinal muscular atrophy
2021. p. S131 – S132. DOI : 10.1016/j.nmd.2021.07.295.CSP alpha reduces aggregates and rescues striatal dopamine release in alpha-synuclein transgenic mice
Brain. 2021. Vol. 144, p. 1661 – 1669. DOI : 10.1093/brain/awab076.Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder
Translational Psychiatry. 2021. Vol. 11, num. 1, p. 293. DOI : 10.1038/s41398-021-01387-7.IL10-and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression
Frontiers In Immunology. 2021. Vol. 12, p. 607315. DOI : 10.3389/fimmu.2021.607315.SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease
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Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Acta Neuropathologica Communications. 2020. Vol. 8, num. 1, p. 198. DOI : 10.1186/s40478-020-01069-3.Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B
Hearing Research. 2020. Vol. 394, p. 107882. DOI : 10.1016/j.heares.2020.107882.Nano-imaging trace elements at organelle levels in substantia nigra overexpressing alpha-synuclein to model Parkinson’s disease
Communications Biology. 2020. Vol. 3, num. 1, p. 364. DOI : 10.1038/s42003-020-1084-0.Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice
Movement Disorders. 2020. Vol. 45, num. 10, p. 1843 – 1853. DOI : 10.1002/mds.28190.Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy
Journal Of Neuromuscular Diseases. 2020. Vol. 7, num. 3, p. 315 – 322. DOI : 10.3233/JND-200493.2019
Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer’s Disease Mouse Model
Antioxidants & Redox Signaling. 2019. Vol. 31, num. 18, p. 1321 – 1338. DOI : 10.1089/ars.2019.7754.Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice
2019. ESGCT 27th Annual Congress in collaboration with SETGyc Meeting, Barcelona, SPAIN, Oct 22-25, 2019. p. A106 – A107.Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery
2019. ESGCT 27th Annual Congress in collaboration with SETGyc Meeting, Barcelona, SPAIN, Oct 22-25, 2019. p. A11 – A12.Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
Nature Medicine. 2019. Vol. 25, num. 7, p. 1123 – 1130. DOI : 10.1038/s41591-019-0500-9.Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Journal of Cerebral Blood Flow and Metabolism. 2019. Vol. 39, num. 7, p. 1283 – 1298. DOI : 10.1177/0271678X18756499.Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells
Molecular Therapy-Methods & Clinical Development. 2019. Vol. 13, p. 14 – 26. DOI : 10.1016/j.omtm.2018.11.004.The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
Molecular Cell. 2019. Vol. 73, num. 4, p. 775 – 787.e10. DOI : 10.1016/j.molcel.2018.11.034.Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy
Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019. Vol. 116, num. 6, p. 2328 – 2337. DOI : 10.1073/pnas.1810932116.Compositions and methods for delivering nucleic acids to cochlear and vestibular cells
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2019.Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease
Lausanne, EPFL, 2019.A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Lausanne, EPFL, 2019.2018
An miRNA-based gene therapy approach to target mutated SOD1 in key cell types in amyotrophic lateral sclerosis (ALS)
2018. Conference on Changing the Face of Modern Medicine – Stem Cell and Gene Therapy, Lausanne, SWITZERLAND, Oct 16-19, 2018. p. A80 – A80.Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development
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2018. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Chicago, IL, May 16-19, 2018. p. 138 – 139.Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
Nature Neuroscience. 2018. Vol. 21, num. 4, p. 576 – 588. DOI : 10.1038/s41593-018-0093-5.PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2018. Vol. 89, num. 8, p. 870 – 878. DOI : 10.1136/jnnp-2017-317562.Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate
JCI INSIGHT. 2018. Vol. 3, num. 14, p. e98202. DOI : 10.1172/jci.insight.98202.Encapsulation device
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2018. p. 120 – 134. DOI : 10.1093/hmg/ddx389.Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?
Cell Death & Disease. 2018. Vol. 9, p. 333. DOI : 10.1038/s41419-017-0125-1.PM20D1 is a quantitative trait locus associated with Alzheimer’s disease
Nature Medicine. 2018. Vol. 24, num. 5, p. 598 – 603. DOI : 10.1038/s41591-018-0013-y.2017
In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system
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