Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Z. M. Xu; G. E. Gnouamozi; S. Rueger; P. R. Shea; M. Buti et al. 

ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction

E. Fasana; I. Fregno; C. Galli; T. Solda; M. Molinari 

Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases

Y. Tschan; M. Sasamalo; H. Hiza; J. Fellay; S. Gagneux et al. 

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

J. Gao; S. Zhang; P. Deng; Z. Wu; B. Lemaitre et al. 

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

H. Hiza; M. Zwyer; J. Hella; A. Arbues; M. Sasamalo et al. 

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

P. A. Ginno; H. Borgers; C. Ernst; A. Schneider; M. Behm et al. 

The conceptual foundations of innate immunity: Taking stock 30 years later

Pradeu Thomas; Thomma Bart T.P.H.; Girarding Stephen; B. Lemaitre 

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

A. M. Olmo-Fontanez; J. M. Scordo; A. Schami; A. Garcia-Vilanova; P. A. Pino et al. 

Cold stress-induced autophagy and apoptosis disorders are mainly mediated by AMPK/PPAR/PI3K/AKT/mTOR pathways

D. Wang; Y. Tian; Q. Wang; Y. Zhang; B. Ye et al. 

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

P. Xu; Y. Liu; C. Liu; B. Guey; L. Li et al. 

Open-source microscope add-on for structured illumination microscopy

M. T. M. Hannebelle; E. Raeth; S. M. Leitao; T. Lukes; J. Pospisil et al. 

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

J. P. H. Wong; N. Chillier; M. Fischer-Stettler; S. C. Zeeman; T. J. Battin et al. 

Mechanisms and functions of protein S-acylation

F. S. Mesquita; L. Abrami; M. E. Linder; S. X. Bamji; B. C. Dickinson et al. 

The dynamic genetic determinants of increased transcriptional divergence in spermatids

J. Panten; T. Heinen; C. Ernst; N. Eling; R. E. Wagner et al. 

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

A. Y. Chong; N. Brenner; A. Jimenez-Kaufmann; A. Cortes; M. Hill et al. 

A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

N. Moullan; J. Asiago; K. Stecco; S. Hadi; M. Albizem et al. 

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (vol 15, 22, 2023)

D. Matuozzo; E. Talouarn; A. Marchal; P. Zhang; J. Manry et al. 

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

J. Sollier; M. Basler; P. Broz; P. S. Dittrich; K. Drescher et al. 

Molecular mechanism of plasmid elimination by the DdmDE defense system

L. Loeff; D. W. Adams; C. Chanez; S. Stutzmann; L. Righi et al. 

Q & A – Melanie Blokesch

M. Blokesch 

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system

S. B. Otto; R. M. Servajean; A. Lemopoulos; A-F. Bitbol; M. Blokesch 

Capsular Polysaccharide Restrains Type VI Secretion in Acinetobacter baumannii

N. O. Flaugnatti; L. Bader; M-C. Croisier-Coeytaux; M. Blokesch 

Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae’s environmental lifestyle

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

G. Vizzarro; A. Lemopoulos; D. W. Adams; M. Blokesch 

Mitochondria-specific signature of oxidative damage in human cancers: an excess of A>G on heavy chain of the mitochondrial genome in slow-dividing normoxic tissues

B. Efimenko; A. Mikhailova; K. Popadin 

Prevalence of actionable pharmacogenetic variants in a Swiss hospital cohort

F. Hodel; M. De Min; C. Thorball; J. Fellay 

Inborn errors of type I interferon immunity in patients with severe acute hepatitis E

A. Saadat; J. Gouttenoire; D. Moradpour; J. Fellay; M. F. Christinet 

Prevalence of clonal hematopoiesis in people living with HIV

V. Timonina; K. Popadin; J. Fellay 

Aneuploid human embryos are associated with increased maternal age, poor embryo morphology, high mitochondrial content and advanced development day of the biopsy: an analysis of 15’000 embryonic genomes

M. Ri; N. Ree; M. Tofilo; A. Kirillova; I. Zvereva et al. 

The impact of human genetics on Mycobacterium tuberculosis intra-host evolution

Z. M. Xu; M. Zwyer; D. Brites; H. Hiza; M. Reinhard et al. 

Low mitochondrial content marks high health status of human euploid embryos

K. Popadin; M. Ri; N. Ree; M. Tofilo; I. Zvereva et al. 

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

F. Martins; O. Rosspopoff; J. Carlevaro-Fita; R. Forey; S. Offner et al. 

Reply to Dages et al: You AIn’t using it right-artificial intelligence progress in allergy

D. Lawless 

Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells

G. Tax; K. P. Guay; L. Pantalone; M. Ceci; T. Solda et al. 

Control of nuclear envelope dynamics during acute ER stress by LINC complexes disassembly and selective, asymmetric autophagy of the outer nuclear membrane

M. K. Kucinska; M. Molinari 

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

A. Lemopoulos; B. Miwanda; N. C. Drebes Dorr; S. Stutzmann; D. Bompangue et al. 

Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer

N. M. R. Lykoskoufis; E. Planet; H. Ongen; D. Trono; E. T. Dermitzakis 

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

W. Matsushima; E. Planet; D. Trono 

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations

The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control

M. Rahmouni; L. De Marco; J-L. Spadoni; M. Tison; R. Medina-Santos et al. 

Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E

A. Saadat; J. Gouttenoire; P. Ripellino; D. Semela; S. Amar et al. 

Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort

Q. dos Santos; P. Leung; C. W. Thorball; B. Ledergerber; J. Fellay et al. 

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

D. G. Ryan; C. G. Peace; A. Hooftman 

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

T. Le Voyer; A. V. Parent; X. Liu; A. Cederholm; A. Gervais et al. 

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish

D. Wang; X. Leng; Y. Tian; J. Liu; J. Zou et al. 

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

M. U. Anwar; F. G. van der Goot 

Inborn Errors of Type I Interferon Immunity in Patients with Severe Acute Hepatitis E

A. Saadat; J. Gouttenoire; P. Ripellino; D. Semela; S. Amar et al. 

Inflammatory mitochondrial nucleic acids as drivers of pathophysiology

C. G. Peace; A. Hooftman; D. G. Ryan 

Investigating the composition and recruitment of the mycobacterial ImuA’-ImuB-DnaE2 mutasome

S. Gessner; Z. A-M. Martin; M. A. Reiche; J. A. Santos; R. Dinkele et al. 

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

P. J. J. McLaren; I. Porreca; G. Iaconis; H. P. Mok; S. Mukhopadhyay et al. 

cGAS-STING drives ageing-related inflammation and neurodegeneration

M. F. Gulen; N. Samson; A. Keller; M. Schwabenland; C. Liu et al. 

Variation in African genomes linked to control of HIV

P. J. McLaren; J. Fellay 

Pseudomonas aeruginosa type IV pili actively induce mucus contraction to form biofilms in tissue-engineered human airways

T. Rossy; T. Distler; L. Meirelles; J. Pezoldt; J. Kim et al. 

Protein target highlights in CASP15: Analysis of models by structure providers

L. T. Alexander; J. Durairaj; A. Kryshtafovych; L. A. Abriata; Y. Bayo et al. 

A metagenome-wide association study of HIV disease progression in HIV controllers

L. M. Real; M. E. Saez; A. Corma-Gomez; A. Gonzalez-Perez; C. Thorball et al. 

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

M. A. Hanson; L. Grollmus; B. Lemaitre 

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in & SIM;40% of patients

A. Gervais; F. Rovida; M. A. Avanzini; S. Croce; A. Marchal et al. 

Fluid flow structures gut microbiota biofilm communities by distributing public goods

J. P. H. Wong; M. F-Stettler; S. C. Zeeman; T. J. Battin; A. Persat et al. 

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

L. Vidakovic; S. Mikhaleva; H. Jeckel; V. Nisnevich; K. Strenger et al. 

Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH

C. Vergara; J. F. Tuff; J. Int Collaboration Genomics HIV ICGH; J. Fellay; P. Duggal et al. 

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

J. M. Schwenke; C. W. Thorball; I. C. Schoepf; L. Ryom; B. Hasse et al. 

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

E. Porcu; C. Thorball; A. P. Porretta; E. Pruvot; K. Wiskott et al. 

Host genomic susceptibility to severe respiratory syncytial virus infection

A. Saadat; D. Lawless; J. Fellay 

A polygenic risk score improves the prediction of cardiovascular risk associated with obstructive sleep-apnoea

C. Thorball; M. Berger; G. Solelhac; A. Waeber; C. Redin et al. 

Secondary structure of the human mitochondrial genome affects formation of deletions

V. Shamanskiy; A. A. Mikhailova; E. O. Tretiakov; K. Ushakova; A. G. Mikhailova et al. 

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

D. Lawless; C. G. McKennan; S. R. Das; T. Junier; Z. M. Xu et al. 

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years

I. C. Schoepf; A. Esteban-Cantos; C. W. Thorball; B. Rodes; P. Reiss et al. 

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

D. Matuozzo; E. Talouarn; A. Marchal; P. Zhang; J. Manry et al. 

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

D. Ni; P. Turelli; B. Beckert; S. Nazarov; E. Uchikawa et al. 

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

M. A. Hanson; B. Lemaitre 

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

M. Zwyer; L. Rutaihwa; E. Windels; J. Hella; F. Menardo et al. 

Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

C. Toniolo; N. Dhar; J. D. McKinney 

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

M. J. Kuhn; H. Macmillan; L. Tala; Y. Inclan; R. Patino et al. 

Associations of genetic and infectious risk factors with coronary heart disease

F. Hodel; Z. M. Xu; C. W. Thorball; R. de la Harpe; P. Letang-Mathieu et al. 

Species-specific regulation of XIST by the JPX/FTX orthologs

O. Rosspopoff; E. Cazottes; C. Huret; A. Loda; A. J. Collier et al. 

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

E. F. Avery; J. N. Kleynhans; B. Ledergerber; I. C. Schoepf; C. W. Thorball et al. 

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

R. de La Harpe; C. W. Thorball; C. Redin; S. Fournier; O. Mueller et al. 

Dynamics of CLIMP-63 S-acylation control ER morphology

P. A. Sandoz; R. A. Denhardt-Eriksson; L. Abrami; L. A. Abriata; G. Spreemann et al. 

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

Z. Fleischmann; A. C-‘Heureux; M. Franco; S. Oreshkov; S. Annis et al. 

Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

P. D. Odermatt; P. Nussbaum; S. Monnappa; L. Tala; Z. Li et al. 

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

L. V. F. Novak; S. C. Treitli; J. Pyrih; P. Halakuc; S. V. Pipaliya et al. 

Tau accumulation in degradative organelles is associated to lysosomal stress

E. Piovesana; C. Magrin; M. Ciccaldo; M. Sola; M. Bellotto et al. 

Deamination of adenine to guanine is a signature of oxidative damage in mitochondrial DNA

A. Mikhailova; E. Tretiakov; V. Shamanskiy; D. Iliushchenko; V. Yurov et al. 

Statistical learning quantifies transposable element-mediated cis-regulation

C. Pulver; D. Grun; J. Duc; S. Sheppard; E. Planet et al. 

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

F. S. Mesquita; L. Abrami; L. Bracq; N. Panyain; V. Mercier et al. 

New ingredients for old recipes

O. Rosspopoff; F. Martins; D. Trono 

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system

S. B. Otto; R. M. Servajean; A. Lemopoulos; A-F. Bitbol; M. Blokesch 

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

C. Fenwick; P. Turelli; Y. Duhoo; K. Lau; C. Herate et al. 

Functional characterization of Drosophila melanogaster immune effectors

TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress

M. K. Kucinska; J. Fedry; C. Galli; D. Morone; A. Raimondi et al. 

PSGL-1 is an evolutionarily conserved antiviral restriction factor

C. Jiang; M. Mei; Y. Liu; M. Hou; J. Jiao et al. 

Take a walk on the KRAB side

O. Rosspopoff; D. Trono 

Genetic features and genomic targets of human KRAB-zinc finger proteins

J. de Tribolet-Hardy; C. W. Thorball; R. Forey; E. Planet; J. Duc et al. 

Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking

M. T. Shaku; K. L. Ocius; A. J. Apostolos; M. M. Pires; M. S. Vannieuwenhze et al. 

Prevalence of CFTR variants in primary immunodeficiency patients with bronchiectasis is an important modifying cofactor

D. Lawless; H. L. Allen; J. E. D. Thaventhiran; S. Goddard; O. S. Burren et al.